Periostin is a novel therapeutic target that predicts and regulates glioma malignancy

Mikheev, Andrei M.; Mikheeva, Svetlana A.; Trister, Andrew D.; Tokita, Mari; Emerson, Samuel; Parada, Carolina; Born, Donald E.; Bárbara, Cristina; Frankel, Sam; Kim, Deok Ho; Oxford, Rob G.; Kosai, Yoshito; Tozer-Fink, Kathleen R.; Manning, Thomas C.; Silber, John R.; Rostomily, Robert

doi:10.1093/neuonc/nou161

Cited by 67 publications

(89 citation statements)

References 42 publications

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“…Furthermore, CSCs release the extracellular matrix protein periostin that accumulates in the perivascular tumor niche and acts as another chemoattractant for TAMs via integrin receptor α v β 3 signaling, facilitating the migration of macrophages to the niche [44]. Congruent with the observation that the number of TAMs relates to tumor grade, periostin is highly upregulated in GBM, and its levels directly correlate with tumor grade and recurrence [45]. …”

Section: The Perivascular Gbm Nichementioning

confidence: 99%

Glioblastoma: Defining Tumor Niches

2015

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Glioblastomas (GBM) are one of the most recalcitrant brain tumors because of their aggressive invasive growth and resistance to therapy. They are highly heterogeneous malignancies at both the molecular and histological levels. Specific histological hallmarks including pseudopalisading necrosis and microvascular proliferation distinguish GBM from lower-grade gliomas, and make GBM one of the most hypoxic as well as angiogenic tumors. These microanatomical compartments present specific niches within the tumor microenvironment that regulate metabolic needs, immune surveillance, survival, invasion as well as cancer stem cell maintenance. Here we review features and functions of the distinct GBM niches, detail the different cell constituents and the functional status of the vasculature, and discuss prospects of therapeutically targeting GBM niche constituents.

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Section: The Perivascular Gbm Nichementioning

confidence: 99%

Glioblastoma: Defining Tumor Niches

2015

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“…Increased expression of POSTN has been observed in various tumor types, including breast [44,48,[56][57][58], NSCLC [27,49,[59][60][61][62], colorectal [19,29,63], stomach cancers [64][65][66][67][68], pancreatic [32,69], prostate [70][71][72][73][74][75], ovarian cancer [76][77][78][79], and glioblastomas [80][81][82] (Table 1).…”

Section: Periostin Expression In Different Types Of Tumorsmentioning

confidence: 99%

The role of periostin in neoplastic processes

Ratajczak‐Wielgomas

Dzięgiel

2015

Folia Histochem Cytobiol.

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Periostin, also called osteoblast-specific factor 2 (OSF-2), is a multifunctional glycoprotein that belongs to the group of matricellular proteins. Due to its characteristic molecular structure containing integrin-binding domains, periostin is capable of binding to multiple integrin receptors (avb3, avb5, a6b4), thus affecting the regulation of the intracellular signaling pathways associated with protein kinases PI3K/AKT and focal adhesion kinase (FAK). This protein thus plays a role in the adhesion process, in the migration of many cells, and importantly, epithelial-mesenchymal transition of cancer cells. Periostin also participates in the processes of angiogenesis and lymphangiogenesis, metastases of cancer cells, and remodeling of the extracellular matrix. Increased expression of periostin has been observed in various tumor types, including breast, NSCLC, colorectal, pancreatic, prostate, and ovarian cancers, as well as tumors of the head and neck, and glioblastomas. Many groups have recently reported on periostin's key role in tumor progression, which suggests that periostin can be considered a potential therapeutic target.

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“…In each of these cancers, the presence of periostin is associated with metastasis, progression, and poor survival. The therapeutic inhibition of periostin has been proposed as a method to reduce tumor growth and metastasis, and improve survival, particularly in gastric cancer and glioma (259, 260). This strategy was used successfully in an orthotopic breast cancer xenograft (261).…”

Section: Introductionmentioning

confidence: 99%

Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization

Sawyer

Kyriakides

2016

Advanced Drug Delivery Reviews

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Extracellular matrix is composed by a complex array of molecules that together provide structural and functional support to cells. These properties are mainly mediated by the activity of collagenous and elastic fibers, proteoglycans, and proteins such as fibronectin and laminin. ECM composition is tissue-specific and could include matricellular proteins whose primary role is to modulate cell-matrix interactions. In adults, matricellular proteins are primarily expressed during injury, inflammation and disease. Particularly, they are closely associated with the progression and prognosis of cardiovascular and fibrotic diseases, and cancer. This review aims to provide an overview of the potential use of matricellular proteins in drug delivery including the generation of therapeutic agents based on the properties and structures of these proteins as well as their utility as biomarkers for specific diseases.

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Periostin is a novel therapeutic target that predicts and regulates glioma malignancy

Abstract: Periostin is a robust marker of glioma malignancy and potential tumor recurrence. Abrogation of glioma stem cell tumorigenicity after periostin inhibition provides support for exploring the therapeutic impact of targeting periostin.

Cited by 67 publications

References 42 publications

Glioblastoma: Defining Tumor Niches

Glioblastoma: Defining Tumor Niches

The role of periostin in neoplastic processes

Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization

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