Periostin increases migration and proliferation of human periodontal ligament fibroblasts challenged by tumor necrosis factor ‐α and Porphyromonas gingivalis lipopolysaccharides

Abstract

Periostin acts as an important modulator of hPDL cell-matrix dynamics. It modulates hPDL proliferation, migration and PI3K/AKT/mTOR pathway. It also helps in overcoming the altered biological phenotype that chronic exposure to periodontal pathogens and proinflammatory cytokines produce in hPDL cells.

Periostin promotes migration and osteogenic differentiation of human periodontal ligament mesenchymal stem cells via the Jun amino‐terminal kinases (JNK) pathway under inflammatory conditions

“…38,39 A former study reported that exogenous POSTN restores TNFα-suppressed migration of PDL cells. 36 These results indicated that suppression of PDL cell migration by TNFα may be caused by a decrease of POSTN. In the present study, we discovered that TNFα…”

Distinct expression pattern of periostin splice variants in chondrocytes and ligament progenitor cells

“…Previously, we (16) and others (56,57) have shown that POSTN affects cell migration. In the current study, we show that cells expressing total POSTN exhibit heightened adhesion more than cells lacking POSTN or cells overexpressing isoform 1.…”

Preliminary insight into the periostin leverage during periodontal tissue healing

“…, Padial‐Molina et al. ) and induces migration and proliferation through the interaction with α v β 3 and α v β 5‐integrins (Li et al. , Utispan et al.…”

“…, Padial‐Molina et al. ). Similar to other highly homologous proteins such as βigH3, periostin expression is regulated by TGF‐ß in response to mechanical stimulation (Rios et al.…”