Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos–overexpressing bone lesions

Kashima, Takeshi; Nishiyama, Takashi; Shimazu, Kazuhiro; Shimazaki, Masashi; Kii, Isao; Grigoriadis, Agamemnon E.; Fukayama, Masashi; Kudo, Akira

doi:10.1016/j.humpath.2008.07.008

Cited by 94 publications

(66 citation statements)

References 32 publications

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“…We now confirm similar alterations in type I collagen fibers of the Postn Ϫ/Ϫ periosteal bone by electron microscopy. Second, periostin activates the integrin signaling pathways (Akt/phosphatidylinositol 3-kinase) (42,43), which we also found in UMR-106 osteoblast-like cells (data not shown). Integrins are known to mediate osteocyte response to mechanical stimulation (44,45), and it is possible therefore that periostin contributes to Sost inhibition by co-activating integrin signaling in these cells.…”

Section: Discussionsupporting

confidence: 62%

The Matricellular Protein Periostin Is Required for Sost Inhibition and the Anabolic Response to Mechanical Loading and Physical Activity

Bonnet

Standley

Bianchi

et al. 2009

Journal of Biological Chemistry

187

205

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Section: Discussionsupporting

confidence: 62%

The Matricellular Protein Periostin Is Required for Sost Inhibition and the Anabolic Response to Mechanical Loading and Physical Activity

Bonnet

Standley

Bianchi

et al. 2009

Journal of Biological Chemistry

187

205

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“…At that time we did speculate that the mechanotransduction properties of bone could be impaired because of an alteration of the bone matrix quality, or alternatively, that Postn could directly regulate Sost. The present work demonstrates that Postn directly inhibits Sost expression through its integrin αVβ3 receptor (26,27). However, in UMR-106 cells, about half of Sost inhibition by PTH appeared independent of Postn.…”

Section: Discussionmentioning

confidence: 48%

Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin

Bonnet

Conway

Ferrari

2012

Proc. Natl. Acad. Sci. U.S.A.

130

112

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Periostin (Postn) is a matricellular protein preferentially expressed by osteocytes and periosteal osteoblasts in response to mechanical stimulation and parathyroid hormone (PTH). Whether and how periostin expression influences bone anabolism, however, remains unknown. We investigated the skeletal response of adult Postn −/− and Postn +/+ mice to intermittent PTH. Compared with Postn +/+ , Postn −/− mice had a lower bone mass, cortical bone volume, and strength response to PTH. PTH-stimulated bone-forming indices were all significantly lower in Postn −/− mice, particularly at the periosteum. Furthermore, in vivo stimulation of Wnt-β-catenin signaling by PTH, as evaluated in TOPGAL reporter mice, was inhibited in the absence of periostin (TOPGAL;Postn −/− mice). PTH stimulated periostin and inhibited MEF2C and sclerostin (Sost) expression in bone and osteoblasts in vitro. Recombinant periostin also suppressed Sost expression, which was mediated through the integrin αVβ3 receptor, whereas periostin-blocking antibody prevented inhibition of MEF2C and Sost by PTH. In turn, administration of a Sost-blocking antiboby partially restored the PTH-mediated increase in bone mass in Postn −/− mice. In addition, primary osteoblasts from Postn −/− mice showed a lower proliferation, mineralization, and migration, both spontaneously and in response to PTH. Osteoblastic gene expression levels confirmed a defect of Postn −/− osteoblast differentiation with and without PTH, as well as an increased osteoblast apoptosis in the absence of periostin. These data elucidate the complex role of periostin on bone anabolism, through the regulation of Sost, Wnt-β-catenin signaling, and osteoblast differentiation.

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“…Periostin clearly plays crucial roles in tissue repair. However, in some cases, chronic or superabundant periostin expression can accelerate pathogenesis of tumours (22,23), bronchial asthma (24,25), atopic dermatitis (26,27), polycystic kidney disease, and other fibrotic diseases (28). As recently reported, periostin promotes chronic inflammation by activating nuclear factor kappa B (NF-ĸB) signaling (26,29,30).…”

Section: Discussionmentioning

confidence: 93%

Influence of IL13 on Periostin Secretion by Synoviocytes in Osteoarthritis

Moue

Tajika

Ishikawa

et al. 2017

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Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos–overexpressing bone lesions

Cited by 94 publications

References 32 publications

The Matricellular Protein Periostin Is Required for Sost Inhibition and the Anabolic Response to Mechanical Loading and Physical Activity

The Matricellular Protein Periostin Is Required for Sost Inhibition and the Anabolic Response to Mechanical Loading and Physical Activity

Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin

Influence of IL13 on Periostin Secretion by Synoviocytes in Osteoarthritis

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