Periosteal Bone Formation Elicited by Partially Purified Bone Morphogenetic Protein

Nakahara, Haruhiko; Takaoka, Kunio; Koezuka, Masahiro; Sugamoto, Kazuomi; Tsuda, Teruhisa; Ono, Katsuhiko

doi:10.1097/00003086-198902000-00031

Cited by 41 publications

(16 citation statements)

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“…It was reported that rhBMP by itself is sufficient to induce bone formation; however, the rapid diffusion of the water-soluble protein rhBMP from the implantation site will reduce its osteoinductive effect [10]. It has been shown that the therapeutic outcome of rhBMP-2 depends on its quantity, concentration, and time of application [11,12].…”

Section: Introductionmentioning

confidence: 99%

Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers

et al. 2005

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Section: Introductionmentioning

confidence: 99%

Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers

et al. 2005

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“…Recombinant human bone morphogenetic proteins (rhBMPs) have been shown to possess significant osteoinductive potential [1][2][3][4][5][6], but in order to take advantage of this effect for tissue engineering, carrier systems are essential [7,8].…”

Section: Introductionmentioning

confidence: 99%

The effect of a fibrin-fibronectin/β-tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects

et al. 2006

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“…For OPs to effectively induce bone healing, a carrier material may be needed. Nakahara et al13 have shown that soluble bone proteins diffuse rapidly when placed in vivo , and the rate of diffusion may mitigate the effects of the protein. In mice, implants of bone protein in gelatin formed bone in superperiosteal sites; however, implants of bone protein alone in the same dosage did not.…”

Section: Introductionmentioning

confidence: 99%

Bone defect healing with an osteogenic protein‐1 device combined with carboxymethylcellulose

2005

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One consideration for the practical use and application of osteogenic proteins is an effective method of delivery. This study evaluated a putty-type collagen carrier with recombinant human osteogenic protein-1 (rhOP-1) ability to heal canine critical sized (2.5 cm) ulna segmental defects compared to rhOP-1 with a particulate collagen carrier (OP device). The addition of carboxymethylcellulose (CMC) to the particulate collagen carrier (OPCMC device) to form the putty consistency was evaluated in two doses (3.5 and 1.75 mg rhOP-1/g carrier). The CMC greatly improved the intraoperative handling and site containment of the device. For the one-half dose and full-dose sites there were no statistically significant differences in the radiographic grading of defect healing when treated with the particulate OP-1 device and the device with CMC added. However, there was a dose effect with greater and earlier new bone formation observed with increased rhOP-1. Mechanically, there were no differences between particulate and putty formulations, although again, a significant effect was observed for treatment dose with the full-dose OPCMC device restoring 94% of the strength of the intact ulna compared to only 65% for the identical one-half dose implant. Regardless of rhOP-1 dose, the quality of union grading and total histologic score appearance were improved with the addition of CMC, although differences in histologic scoring were not statistically significant. Overall, the radiographic, mechanical, and histologic bone-healing characteristics with the one-half dose OPCMC device were similar to sites treated with the full-dose OP device. The observed improvement in healing may allow for lesser amounts of the device or a device with less rhOP-1 to be used.

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Periosteal Bone Formation Elicited by Partially Purified Bone Morphogenetic Protein

Cited by 41 publications

References 0 publications

Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers

Ectopic bone formation associated with recombinant human bone morphogenetic proteins-2 using absorbable collagen sponge and beta tricalcium phosphate as carriers

The effect of a fibrin-fibronectin/β-tricalcium phosphate/recombinant human bone morphogenetic protein-2 system on bone formation in rat calvarial defects

Bone defect healing with an osteogenic protein‐1 device combined with carboxymethylcellulose

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