1989
DOI: 10.1097/00003086-198902000-00031
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Periosteal Bone Formation Elicited by Partially Purified Bone Morphogenetic Protein

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Cited by 41 publications
(16 citation statements)
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“…It was reported that rhBMP by itself is sufficient to induce bone formation; however, the rapid diffusion of the water-soluble protein rhBMP from the implantation site will reduce its osteoinductive effect [10]. It has been shown that the therapeutic outcome of rhBMP-2 depends on its quantity, concentration, and time of application [11,12].…”
Section: Introductionmentioning
confidence: 99%
“…It was reported that rhBMP by itself is sufficient to induce bone formation; however, the rapid diffusion of the water-soluble protein rhBMP from the implantation site will reduce its osteoinductive effect [10]. It has been shown that the therapeutic outcome of rhBMP-2 depends on its quantity, concentration, and time of application [11,12].…”
Section: Introductionmentioning
confidence: 99%
“…Recombinant human bone morphogenetic proteins (rhBMPs) have been shown to possess significant osteoinductive potential [1][2][3][4][5][6], but in order to take advantage of this effect for tissue engineering, carrier systems are essential [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…For OPs to effectively induce bone healing, a carrier material may be needed. Nakahara et al13 have shown that soluble bone proteins diffuse rapidly when placed in vivo , and the rate of diffusion may mitigate the effects of the protein. In mice, implants of bone protein in gelatin formed bone in superperiosteal sites; however, implants of bone protein alone in the same dosage did not.…”
Section: Introductionmentioning
confidence: 99%