Periorbital Cellulitis Caused by Bacillus Thuringiensis

Peker, Erdal; Çağan, Eren; Doğan, Murat; Kılıç, Adil; Çaksen, Hüseyîn; Yeşilmen, Osman

doi:10.1177/112067211002000139

Cited by 13 publications

(11 citation statements)

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“…In the present series, one of the patients infected by Bacillus presented an IOFB, and the other, a wound with soil. One of the two patients had been infected by Bacillus thuringiensis , a pathogenic agent rarely identified in ocular or periocular infections (Peker et al. 2010), responsible in this patient for a serious and rapidly evolving infection, possibly secondary to the production of toxin and its extreme mobility (Callegan et al.…”

Section: Discussionmentioning

confidence: 99%

A multicentre prospective study of post‐traumatic endophthalmitis

Cornut

Youssef

Bron

et al. 2012

Acta Ophthalmologica

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ABSTRACT.Purpose: Study the clinical and microbiological characteristics and the prognostic factors of post-traumatic endophthalmitis. Methods: Seventeen eyes were included between 2004 and 2010, with clinical and microbiological data collected prospectively. Conventional cultures and panbacterial PCR were performed on aqueous and vitreous samples. Results: Clinical signs of endophthalmitis were observed soon after trauma (1.5 ± 2.5 days). Laceration with an intraocular foreign body (IOFB) was noted in 53% of the patients. At admission, all patients had aqueous humour (71%) and ⁄ or vitreous (53%) samples. Fifteen patients (88%) underwent a pars plana vitrectomy. Bacteria were identified in 77% of the cases: Staphylococcus epidermidis (n = 5), Streptococcus (n = 4), Bacillus (n = 2), Pseudomonas stuzeri (n = 1), and Streptococcus salivarius and Gemella haemolysans (multibacterial infection, n = 1). Progression toward phthisis was observed in 35% of the cases; 41% of the patients recuperated visual acuity (VA) ‡20 ⁄ 40. A good final visual prognosis ( ‡20 ⁄ 40) was significantly associated with initial VA better than light perception (0% versus 70%, p = 0.01) and absence of pupillary fibrin membrane (80% versus 20%, p = 0.05). There was no correlation between visual prognosis and age, the type of laceration (corneal or scleral) or presence of an IOFB. We found a statistical trend toward an association between bacterial virulence and poor final VA. Conclusion: This series showed that better final VA outcomes were associated with initial VA better than light perception, S. epidermidis or culture-negative cases and absence of retinal detachment during the clinical course.

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Section: Discussionmentioning

confidence: 99%

A multicentre prospective study of post‐traumatic endophthalmitis

Cornut

Youssef

Bron

et al. 2012

Acta Ophthalmologica

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“…This member of the B. cereus sensu lato group has traditionally not been viewed as pathogenic, as many of the toxin genes target insects, as opposed to humans. There are cases, however, of human infections by B. thuringiensis in the immunocompromised, with some infections characterized by biofilm development [25–27]. The basis for the present study was to determine whether transferrin would impact B. thuringiensis biofilm levels similar to the process observed in B. cereus .…”

Section: Resultsmentioning

confidence: 99%

Transferrin ImpactsBacillus thuringiensisBiofilm Levels

Garner

Brown

Taplin

et al. 2016

BioMed Research International

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The present study examined the impact of transferrin on Bacillus thuringiensis biofilms. Three commercial strains, an environmental strain (33679), the type strain (10792), and an isolate from a diseased insect (700872), were cultured in iron restricted minimal medium. All strains produced biofilm when grown in vinyl plates at 30°C. B. thuringiensis 33679 had a biofilm biomass more than twice the concentration exhibited by the other strains. The addition of transferrin resulted in slightly increased growth yields for 2 of the 3 strains tested, including 33679. In contrast, the addition of 50 μg/mL of transferrin resulted in an 80% decrease in biofilm levels for strain 33679. When the growth temperature was increased to 37°C, the addition of 50 μg/mL of transferrin increased culture turbidity for only strain 33679. Biofilm levels were again decreased in strain 33679 at 37°C. Growth of B. thuringiensis cultures in polystyrene resulted in a decrease in overall growth yields at 30°C, with biofilm levels significantly decreased for 33679 in the presence of transferrin. These findings demonstrate that transferrin impacts biofilm formation in select strains of B. thuringiensis. Identification of these differences in biofilm regulation may be beneficial in elucidating potential virulence mechanisms among the differing strains.

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“…are considered a minimal threat to human infections overall . Bacillus infections of the eye and ocular tissues is considered rare but reports of endophthalmitis, periorbital cellulitis and other ocular infections have appeared in the literature . Bacillus cereus appears to be the Bacillus spp.…”

Section: Discussionmentioning

confidence: 99%

“…Bacillus thuringiensis is a Gram‐positive, rod‐shaped (bacillus), soil‐dwelling bacterium capable of forming spores and producing crystal proteins/toxins that are used worldwide as insecticides . It is rarely considered to be a pathogen to humans but cases have been reported to include ocular infections, gastroenteritis, oral infections, bacteraemia, pulmonary infection and burn wound infections . B. thuringiensis is found in diverse and widespread environments including leaf litter, soil, water, dust and mammals who eat insects .…”

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confidence: 99%

“…Bacillus thuringiensis is considered to be part of the Bacillus cereus family which contains other Bacillus organisms, such as Bacillus anthracis and Bacillus cereus . Contamination of ocular tissues via wounds, dust exposure, or self‐inoculation via soil‐contaminated hands is possible . A case of recurrent bacterial conjunctivitis caused by B. thuringiensis occurring four times over a seven‐month period follows.…”

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