Perioral wrinkles are associated with female gender, aging, and smoking: Development of a gender-specific photonumeric scale

Chien, Anna L.; Qi, Ji; Cheng, Nancy; Thy, Thy; Mesfin, Missale; Egbers, Robert; Xie, Wenfei; Chow, CB; Chubb, Heather; Sachs, Dana L.; Voorhees, John J.; Kang, Sewon

doi:10.1016/j.jaad.2015.11.042

Cited by 22 publications

(25 citation statements)

References 19 publications

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“…Most skin aging studies have analyzed both sexes together, despite important sex differences that have been described (Akiba et al, 1999;Chien et al, 2016;Luebberding et al, 2014;Paes et al, 2009;Tsukahara et al, 2013). In the sexstratified analyses, we found that men have more wrinkles than women in the lower age groups, but in the highest age group, this is reversed-confirming earlier research (Luebberding et al, 2014).…”

Section: Discussionsupporting

confidence: 82%

Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women

Hamer

Pardo

Jacobs

et al. 2017

Journal of Investigative Dermatology

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Facial wrinkling is one of the most notable signs of skin aging. Men and women show different wrinkling patterns yet the lifestyle and physiological factors underlying these sex-specific patterns are relatively unknown. Here, we investigated sex-specific determinants for facial wrinkles. Wrinkle area was quantified digitally using facial photographs of 3,831 northwestern Europeans (51-98 years, 58% female). Effect estimates from multivariable linear regressions are presented as the percentage difference in the mean value of wrinkle area per unit increase of a determinant (%Δ). Wrinkle area was higher in men (median 4.5%, interquartile range: 2.9-6.3) than in women (3.6%, interquartile range: 2.2-5.6). Age was the strongest determinant, and current smoking (men: 15.5%Δ; women: 30.9%Δ) and lower body mass index (men: 1.7%Δ; women: 1.8%Δ) were also statistically significantly associated with increased wrinkling. Pale skin color showed a protective effect (men: -21.0%Δ; women: -28.5%Δ) and, in men, sunburn tendency was associated with less wrinkling. In women, low educational levels and alcohol use were associated with more wrinkling, whereas female pattern hair loss and a higher free androgen index were associated with less wrinkling. In summary, we validated known and identified additional determinants for wrinkling. Skin aging-reducing strategies should incorporate the sex differences found in this study.

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Section: Discussionsupporting

confidence: 82%

Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women

Hamer

Pardo

Jacobs

et al. 2017

Journal of Investigative Dermatology

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“…Chien et al [13] study in 2016 reported the same findings. It also revealed severe perioral wrinkling in smokers as opposed to nonsmokers with statistical significant difference in women but not men.…”

Section: Discussionsupporting

confidence: 52%

The Effect of Smoking on Facial Aging Among Females in Saudi Arabia

Jamal¹

2017

CRDOA

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“…Given the sex and handedness differences in wrinkle genesis and desquamation severity found in this study, these factors should be considered in the dermatological treatment and counseling of patients. Also, if wrinkles and scaliness of the hand are associated with gender, then sex‐specific photonumeric scales should be developed . The potential benefits of applying this technology to a dermatologic clinical population should be considered.…”

Section: Discussionmentioning

confidence: 99%

In vivo determination of the skin surface topography and biophysical properties of human hands: Effects of sex and hand dominance

Enright

Nikolis

2019

Skin Research and Technology

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Background The effect of hand dominance on the skin topography and parameters associated with skin health and aging is unknown. Methods Healthy adult volunteers were recruited. The following four strata were enrolled: Group 1: male, right handed; Group 2: male, left handed; Group 3: female, right handed; and Group 4: female, left handed. The differences between groups on their surface evaluation of living skin (SELS) parameters were evaluated. These variables included (a) roughness (SER); (b) smoothness (SESM); (c) scaliness (SESC); and (d) wrinkles (SEW). Results A total of twenty subjects were recruited, with five in each stratum. Significant differences between groups were found for SESC [F(7,31) = 2.742, P = .024, partial eta squared = 0.382] and SEW [F(7,31) = 3.705, P = .005, partial eta squared = 0.456]. An evaluation of the descriptive statistics revealed that males had a higher mean SESC value than females and a lower mean SEW value. Moreover, the dominant hand of both sexes had a higher mean SEW value than non‐dominant hands. Conclusions Given the evidence of sex and handedness differences in wrinkle genesis and desquamation severity, these factors should be considered in the dermatological treatment and counseling of patients.

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Perioral wrinkles are associated with female gender, aging, and smoking: Development of a gender-specific photonumeric scale

Cited by 22 publications

References 19 publications

Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women

Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women

The Effect of Smoking on Facial Aging Among Females in Saudi Arabia

In vivo determination of the skin surface topography and biophysical properties of human hands: Effects of sex and hand dominance

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