Perioperative use of the LiMON method of indocyanine green elimination measurement for the prediction and early detection of post-hepatectomy liver failure

Carino, Nicola de Liguori; O’Reilly, Derek; Dajani, Khaled; Ghaneh, Paula; Poston, Graeme J.; Wu, Amy D.

doi:10.1016/j.ejso.2009.02.003

Cited by 72 publications

(55 citation statements)

References 28 publications

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“…After the non-invasive PDD systems became available and a real-time and rapid ICG clearance test was possible, intraoperative estimation of remnant liver function by trial clamping of selective arterial and portovenous inflow was reported [29,50,51]. In addition, early prediction of postoperative liver dysfunction using realtime PDR ICG has also been proposed after major liver resection [30,52] or liver transplantation [53][54][55]. Recent advances in the 3D CT volumetric system in combination with non-invasive PDD systems have made accurate calculation of rem K ICG easier.…”

Section: Pdr Icg or K Icgmentioning

confidence: 99%

ICG Clearance Test and 99mTc-GSA SPECT/CT Fusion Images

Iimuro¹

2017

Visc Med

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Preoperative estimation of future remnant liver function is critical for major hepatic surgery to avoid postoperative morbidity and mortality. Among several liver function tests, the indocyanine green (ICG) clearance test is still the most popular dynamic method. The usefulness of ICG clearance test parameters, such as ICGR15, K_ICG, or PDR_ICG, has been reported by many investigators. The transcutaneous non-invasive pulse dye densitometry system has made the ICG clearance test more convenient and attractive, even in Western countries. The concept of future remnant K_ICG (rem K_ICG), which combines the functional aspect and the volumetric factor of the future remnant liver, seems ideal for determining the maximum extent of major hepatic resection that will not cause postoperative liver failure. For damaged livers with functional heterogeneity among the hepatic segments, fusion images combining technetium-99m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin single photon emission computed tomography (99mTc-GSA SPECT) and X-ray CT are helpful to precisely estimate the functional reserve of the future remnant liver. Another technique for image-based liver function estimation, gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB)-enhanced magnetic resonance imaging, may be an ideal candidate for the preoperative determination of future remnant liver function. Using these methods effectively, morbidity and mortality after major hepatic resection could be reduced.

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Section: Pdr Icg or K Icgmentioning

confidence: 99%

ICG Clearance Test and 99mTc-GSA SPECT/CT Fusion Images

Iimuro¹

2017

Visc Med

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“…Indocyanine green (ICG) is a relatively non−toxic dye [4] which is applied as an optical marker for liver func− tion testing [5][6][7] in ophthalmology [8] and for assessment of hemodynamic parameters [9][10][11]. In experiments carried out on animals it was also shown that the ICG monitoring may allow for evaluation of cerebral blood volume [12].…”

Section: Introductionmentioning

confidence: 99%

Advantages of fluorescence over diffuse reflectance measurements tested in phantom experiments with dynamic inflow of ICG

Milej

Kacprzak

Żołek

et al. 2010

Opto-Electronics Review

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Time-resolved measurements of diffuse reflectance and fluorescence were carried out using phantom with dynamic inflow of indocyanine green (ICG) in tubes located at different depths. Better sensitivity of fluorescence signals related to the inflow of the dye was observed in comparison to simultaneously acquired diffuse reflectance. Obtained results can be referred to results of in-vivo measurements. We have observed much larger amplitude of changes in relative number of detected photons, mean time of flight and variance of the distributions of times of arrival of fluorescence photons than amplitudes of respective parameters measured from diffuse reflectance distributions of times of flight of photons. The constructed phantom allows us to study influence of concentration of the dye in the tube and the surrounding medium as well as temporal relation between appearance of the boli in deeper and superficial tube. Results of the study were used in optimization of the time-resolved multichannel system for simultaneous monitoring of fluorescence and reflectance.

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“…Known factors that induce posttraumatic acute liver failure are shock, direct liver trauma (contusion), partial hepatectomy, abdominal compartment syndrome, hepatic ischemia resulting from hepatic artery or portal vein damage or parenchymal compression by inadequate packing, endotoxemia and hepatotoxic drugs [59]. In addition to established laboratory parameters, not reliably reflecting liver function (INR, PTT, fibrinogen, ammonia, bilirubine, AST, ALT, lactate, blood glucose), the functional liver capacity can be detected by LiMAx and LiMON test [60,61]. A serum bilirubine level exceeding >300 μmol/L has been demonstrated to predict death with a specificity and sensitivity of 87.8% and 90.3%, respectively [41].…”

Section: Ventilation Acute Lung Injury and Adult Respiratory Distresmentioning

confidence: 99%