Perioperative use of esmolol

Rêves, J. G.; Flezzani, Paolo

doi:10.1016/0002-9149(85)90917-8

Cited by 35 publications

(9 citation statements)

References 24 publications

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“…Unfortunately, the tendency of opioid analgesics to delay recovery, particularly of higher cognitive function (lo), as well as to increase the incidence of postoperative nausea and vomiting (11) in outpatients undergoing ambulatory surgical procedures, can significantly delay discharge. A drug capable of rapidly controlling tachycardia and hypertension without prolonged negative inotropic effects would be beneficial for perioperative control of transient hemodynamic responses to surgical stimuli (12). Esmolol compares favorably with fentanyl in its ability to obtund unwanted cardiovascular response to laryngoscopy and tracheal intubation in patients with cardiovascular disease (13,14).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Esmolol Versus Alfentanil as a Supplement to Propofol-Nitrous Oxide Anesthesia

Smith

1991

Anesthesia & Analgesia

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Section: Discussionmentioning

confidence: 99%

Efficacy of Esmolol Versus Alfentanil as a Supplement to Propofol-Nitrous Oxide Anesthesia

Smith

1991

Anesthesia & Analgesia

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“…Die Indikationen, Wirkungen und Nebenwirkungen von Clonidin und Esmolol sind hinlänglich bekannt [15,18] Esmolol ist ein in der Anästhesie und Intensivmedizin häufig verwendeter Vertreter der kardioselektiven Betarezeptorantagonisten.…”

Section: Schlüsselwörterunclassified

Kardiovaskuläre Stressprotektion während der Anästhesieeinleitung

et al. 2001

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Alpha-2-adrenoceptor-agonists as well as cardioselective betareceptor-antagonists have been shown to blunt stress response due to tracheal intubation. The purpose of our study was to investigate,whether clonidine or esmolol is more efficient to attenuate stress response due to intubation.44 patients were randomly assigned to receive either clonidine (n=22; 3 microg/kg) or esmolol (n=22; 2 mg/kg) immediately prior to a standardized induction of anaesthesia. Heart rate, arterial blood pressure, cardiac output, epinephrine and norepinephrine plasma concentrations were measured before,during and 10 min after intubation. Blood pressure was measured invasively and cardiac output was determined by transthoracic echocardiography. Absolute values and increase of mean arterial pressure and norepinephrine plasma concentrations were significantly less in the clonidine group (p<0,05). Clonidine (3 microg/kg) is more efficient than esmolol (2 mg/kg) in blunting stress response due to endotracheal intubation.

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“…Esmolol is also well suited for acute antiarrhythmic interventions (i. e. supraventricular tachyarrhythmias) and for preventing intraoperative stress, which should be very intensive but often brief in duration [13][14][15][16][17].…”

Section: Esmolol (Methyl 3-[4-[2-hydroxy-3-(isopropylamino)mentioning

confidence: 99%

“…Dedicated to Dr. P, Rajagopal, Kuantan Specialist Hospital, Kuantan, Malaysia Esmolol (methyl 3-[4-[2-hydroxy-3-(isopropylamino) propoxy] phenyl]propionate hydrochloride) is an ultrashort-acting fl-adrenoceptor antagonist with an elimination half-life of about 9 min [14]. Based on experiments in isolated organs it has been concluded that esmolol has a higher affinity for /31-than for /32-adrenoceptors.…”

mentioning

confidence: 99%

Esmolol, an ultrashort-acting, selective ?1-adrenoceptor antagonist: pharmacodynamic and pharmacokinetic properties

Volz-Zang

Eckrich

Jahn

et al. 1994

Eur J Clin Pharmacol

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The effects of esmolol at different rates of infusion (100, 250 and 500 micrograms.kg-1 BW.min-1) were compared with beta-adrenoceptor occupancy (beta 1 and beta 2, estimated by a subtype selective radioreceptor assay) and plasma concentrations of esmolol and its acid metabolite were measured by HPLC. Up to a rate of infusion of esmolol of 500 micrograms.kg-1 BW.min-1 there was a maximal beta 1-receptor occupancy of 84.7% while beta 2-receptor occupancy was below the detection limit; confirming the beta 1 selectivity of esmolol. Exercise-induced increases in heart rate and systolic blood pressure were reduced by esmolol in a dose-dependent manner. The estimated EC50 values of rate of infusion for the reduction in heart rate and systolic blood pressure during exercise were 113 and 134 micrograms.kg-1 BW.min-1, respectively. Additionally, heart rate and systolic blood pressure were reduced moderately at rest. Because of the short elimination half-life of esmolol caused by the rapid hydrolysis to its acid metabolite, 45 min after end of infusion high plasma concentrations of the metabolite (maximally 80 micrograms.ml-1) but no esmolol were detectable. Since no in vivo effects have been observed, despite the presence of high plasma concentrations of the metabolite, the metabolite did not participate in the observed effects up to an infusion rate of esmolol of 500 micrograms.kg-1 BW.min-1. The plasma concentrations of antagonist detected by radioreceptor assay and plasma concentrations of esmolol detected by HPLC showed a good correlation (r = 0.97).(ABSTRACT TRUNCATED AT 250 WORDS)

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Perioperative use of esmolol

Cited by 35 publications

References 24 publications

Efficacy of Esmolol Versus Alfentanil as a Supplement to Propofol-Nitrous Oxide Anesthesia

Efficacy of Esmolol Versus Alfentanil as a Supplement to Propofol-Nitrous Oxide Anesthesia

Kardiovaskuläre Stressprotektion während der Anästhesieeinleitung

Esmolol, an ultrashort-acting, selective ?1-adrenoceptor antagonist: pharmacodynamic and pharmacokinetic properties

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