Perioperative targeted temperature management of severely burned patients by means of an oesophageal temperature probe

Core warming of coronavirus disease 2019 (COVID-19) patients undergoing mechanical ventilation - a pilot study

“…Core body temperature is far more tightly regulated than other physiological parameters (including blood pressure and heart rate), and because of the existence of robust thermal defense mechanisms, warming patients to above normal temperatures can be difficult (Sessler, 2009). Previous data have found that core warming with a dedicated esophageal heat transfer device is able to provide warming in patients with particular difficulty in maintaining normothermia, such as burn patients undergoing surgery (Furrer et al, 2022). At present, it remains unclear if a shorter time to a febrile target temperature is beneficial or will be required to demonstrate benefits seen in early clinical studies.…”

“…The provision of heat at the patient's core (where viral replication may be greatest) rather than via peripheral heat transfer across the skin may offer further mechanistic benefits. A dedicated device (ensoETM, Attune Medical, Chicago, IL) offers a means to provide heat through the esophagus using a closed-loop flow of water that can be adjusted to cause temperature change (Furrer et al, 2022). Toward this goal, the aim of this pilot study was to investigate the feasibility of providing febrile-range temperatures to COVID-19 patients requiring mechanical ventilation via core warming, in order to determine if core warming improves respiratory physiology of mechanically ventilated patients with COVID-19, allowing earlier weaning from ventilation, and greater overall survival.…”