Perioperative Sicherheit der intraperitonealen Aerosolchemotherapie – Analyse unserer ersten 111 PIPAC (Pressurized IntraPeritoneal Aerosol Chemotherapy)-Prozeduren

Jansen-Winkeln, B; Thieme, René; Haase, L; Zimmer, J.; Lordick, Florian; Remane, Yvonne; Frontini, Roberto; Gockel, Ines

doi:10.1055/s-0038-1669024

Cited by 3 publications

(11 citation statements)

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“…PIPAC procedures have recently been described in detail by our group 10 and others, 9,14 and are performed laparoscopically under general anesthesia. The standardized pretherapeutic diagnostic laparoscopy is video-documented.…”

Section: Methodsmentioning

confidence: 99%

“…All single-use products and the micropump are disposed and the multiple-use instruments are cleaned and sterilized. 10 The usual procedure lasts 106 ± 4.0 minutes.…”

Section: Methodsmentioning

confidence: 99%

“…9 The surgical technique and safety aspects for patients and for the operating room staff have recently been described by our group. 10…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to multivisceral surgical treatment, such as CRS and hyperthermic intraperitoneal chemotherapy (HIPEC), the surgical trauma needed for PIPAC is minimal, as well as perioperative complication rates and the length of postoperative in-hospital stay. 10…”

Section: Introductionmentioning

confidence: 99%

“…In November 2015, we initiated our monocentric PIPAC registry study (NCT03100708) to investigate perioperative morbidity and mortality and safety. 10 In addition, we analyzed its oncologic efficacy and patients’ prognosis as well as quality of life prospectively. The current article is dedicated to the CRC, appendiceal cancer (AC), and small bowel cancer (SBC) cohort, comprising the second largest tumor entity following gastric cancer within our registry study.…”

Section: Introductionmentioning

confidence: 99%

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Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in patients with peritoneal metastasized colorectal, appendiceal and small bowel cancer

et al. 2019

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Background: Patients with intestinal cancer (colorectal, appendiceal, and small bowel) with peritoneal metastases (PM) have a poor prognosis. We assessed whether pressurized intraperitoneal aerosol chemotherapy (PIPAC) together with systemic chemotherapy is an effective treatment option for these entities in palliative intent. Methods: Between November 2015 and February 2018, prospective data registry was performed (NCT03100708). Thirteen patients with intestinal cancer (median age 61 years [range 49–77]) underwent 26 PIPAC procedures with a median number of 2 interventions per patient (range 1–6). A chemoaerosol consisting of cisplatin/doxorubicin was administered during standard laparoscopy. Results: The median peritoneal carcinomatosis index according to Sugarbaker before the first PIPAC was 14 (range 2–27), and the median ascites volume was 10 mL (range 0–6300 mL). Six patients who received 2 or more PIPAC procedures had decreased and stable ascites volumes, while only 1 patient displayed increased ascites. The median overall survival was 303 days (range 30–490) after the first PIPAC procedure. Conclusions: PIPAC offers a novel treatment option for patients with PM. Our data show that PIPAC is safe and well-tolerated. Ascites production can be controlled by PIPAC in patients with intestinal cancer. Further studies are required to document the significance of PIPAC within palliative therapy concepts. Trial registration: NCT03100708

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Section: Methodsmentioning

confidence: 99%

“…All single-use products and the micropump are disposed and the multiple-use instruments are cleaned and sterilized. 10 The usual procedure lasts 106 ± 4.0 minutes.…”

Section: Methodsmentioning

confidence: 99%

“…9 The surgical technique and safety aspects for patients and for the operating room staff have recently been described by our group. 10…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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