Perioperative sargramostim (recombinant human GM-CSF) induces an increase in the level of soluble VEGFR1 in colon cancer patients undergoing minimally invasive surgery

Laparoscopic Surgery For Colon Cancer - A Favorite Method? A Review of Literature

“…Early postoperative period is responsible for multiple impairements of plasma proteins compound, potentially leading to neoplasmatic tumor growth stimulation (6,(19)(20)(21)(22). These phenomenons may contribute for the findings made by the authors of the paper, describing experimental liver tumor growth 21 days after injecting colon cancer cells to a portal vein in 2 groups of mice.…”

“…It is found, that the fact of minimizing the operative stress allows for better preservation of natural immunity to fight neoplasmatic disease. These remarks are based upon theoretical premises and are strongly supported by experimental studies and clinical observations (6,7,(19)(20)(21)(22)(23)(24)(25).…”

“…Minimizing the operative trauma leads to less immune supression, less impairment of plasma proteins and less stimulation of neoangiogenesis (6,7,9,14,19,20,21,26,27,28). These phenomenons, dependently of extensiveness of surgical procedure may contribute to unintended tumor growth and survival of cancer cells in the operative field, blood stream and distant organs.…”

“…Development of basic science provides modern knowledge pointing to the need for popularisation of miniinvasive methods of colon cancer treatment. Experimental studies prove, that operative trauma leads to tumor growth stimulation in the postoperative period (6,9,(19)(20)(21)(22)(23)28). Postoperative immunosupression consists of: decrease of total lymphocyte count, decrease of Th-1 lymphocytes, decrease of cytotoxic lymphocytes, inhibition of lymphocytes proliferation, suppression of NK cells, impaired monocyte human leukocyte antigen expression and suppression of delayed type hypersensivity response (7,9,27,28).…”

“…These phenomenons, dependently of extensiveness of surgical procedure may contribute to unintended tumor growth and survival of cancer cells in the operative field, blood stream and distant organs. It should be supposed that it may influence the risk of formation of local recurrence and distant metastases (7,19,20,21,23). Decreased risk of infectious complications and quicker return to normal physical activity that follows decreased operative stress allows for quicker receiving an adiuvant therapy.…”