Perioperative oral care can prevent surgical site infection after colorectal cancer surgery: A multicenter, retrospective study of 1,926 cases analyzed by propensity score matching

Nobuhara, Hiroshi; Matsugu, Yasuhiro; Soutome, Sakiko; Hayashida, Shinsaku; Hasegawa, Takumi; Akashi, Mitsuru; Yamada, Shin‐ichi; Kitamura, Hiroshi; Nakahara, Hirokazu; Nakahara, Miyuka; Ueda, Nobuhiro; Kirita, Tadaaki; Nakamura, Tomohisa; Shibuya, Yasuyuki; Mori, Kenya; Yamaguchi, Tomomi

doi:10.1016/j.surg.2022.02.015

Cited by 17 publications

(15 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Japan, oral care before and after surgery has been included in the public medical insurance since 2012 and is commonly performed. In addition, the risk of surgical site infection (SSI) and postoperative pneumonia is significantly reduced by perioperative oral care during surgeries, especially during esophageal cancer [5][6][7][8][9][10], gastric cancer [10], colon cancer [10][11][12], lung cancer [13,14], liver cancer [15], and oral cancer [16], and procedures involving the cardiac [17] and brain [18]. Perioperative oral care has two primary purposes.…”

Section: Introductionmentioning

confidence: 99%

Number of Bacteria in Saliva in the Perioperative Period and Factors Associated with Increased Numbers

Sakamoto

Tanabe

Moriyama

et al. 2022

IJERPH

Self Cite

View full text Add to dashboard Cite

Perioperative oral management is performed to prevent postoperative complications, but its indication and management method are unclear. This study aimed to investigate salivary bacterial counts pre-and postoperatively, and factors related to increased bacterial count postoperatively. We included 121 patients who underwent surgery under general anesthesia and perioperative oral management. The bacterial count in saliva was determined preoperatively, and first and seventh days postoperatively using the dielectrophoresis and impedance measurement methods. The relationships between salivary bacterial count and various variables were analyzed using one-way analysis of variance, Spearman’s rank correlation coefficient, and multiple regression analysis. The salivary bacterial count increased significantly on the first day postoperatively but decreased on the seventh day. Multivariate analysis showed that age (p = 0.004, standardized coefficient β = 0.283) and xerostomia (p = 0.034, standardized coefficient β = 0.192) were significantly correlated with increased salivary bacterial count preoperatively. Salivary bacterial count on the day after surgery was significantly increased in patients with a large number of bacterial counts on the day before surgery after preoperative oral care (p = 0.007, standardized coefficient β = 0.241) and postoperative fasting (p = 0.001, standardized coefficient β = −0.329). Establishing good oral hygiene before surgery and decreasing salivary bacterial count are necessary in patients with a high risk of postoperative surgical site infection or pneumonia, especially in older adults or postoperative fasting.

show abstract

Section: Introductionmentioning

confidence: 99%

Number of Bacteria in Saliva in the Perioperative Period and Factors Associated with Increased Numbers

Sakamoto

Tanabe

Moriyama

et al. 2022

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…A multicentre research of 1,926 colorectal cancer patients indicated that oral care improved postoperative site infections. The oral care group had a considerably poorer outcome than the control group, and lower blood albumin levels were independent risk factors ( Nobuhara et al, 2022 ). According to a meta-analysis of four studies, a low preoperative CRP/albumin (CAR) ratio was associated with a higher overall survival rate following surgery in oral squamous cell carcinoma OSCC patients ( Lu et al, 2023 ).…”

Section: Serum and Salivary Albumin Tests In Recent Oral Health-relat...mentioning

confidence: 99%

“… Cross-sectional Serum and salivary albumin levels Pre-malignancy and oral malignancy Serum and salivary albumin Compared to healthy people, blood albumin declined and salivary albumin increased in oral pre-malignancy and malignancy cases. Yes ( Nobuhara et al, 2022 ) 1,926 patients with colorectal cancer: 808 patients received perioperative oral care and 1,118 did not receive care. Case-control Perioperative oral care Postoperative site infection Serum albumin The oral care group had significantly fewer surgery site infections than the control group.…”

Section: Serum and Salivary Albumin Tests In Recent Oral Health-relat...mentioning

confidence: 99%

Implication of serum and salivary albumin tests in the recent oral health related epidemiological studies: A narrative review

Mahmood,

Kurda,

Qadir

et al. 2024

The Saudi Dental Journal

View full text Add to dashboard Cite

“…In the most recently published systematic review, including only RCT, there was an almost 50% reduction in postoperative infectious complications (RR 0.56, 95% CI 0.46–0.69; P < 0.00001, I 2 = 42%) [ 46 ]. Finally, investigators in Japan have shown that perioperative oral care (professional oral care and oral self-care instruction) resulted in decreased risk of SSI compared to a control group (8.4 vs 15.7%, P < 0.001) [ 50 ].…”

Section: Surgical and Hospital-acquired Infectionmentioning

confidence: 99%

Synbiotics and Surgery: Can Prebiotics and Probiotics Affect Inflammatory Surgical Outcomes?

et al. 2023

View full text Add to dashboard Cite

Purpose of Review Prebiotics, probiotics, and synbiotics have received increasing attention over the years for their beneficial impact on the gut microbiome and for their systemic anti-inflammatory effects. They have also been shown to improve surgical outcomes. Here, we review the inflammatory effects of surgery as well as the data which suggests a benefit of prebiotics, probiotics, and synbiotics taken in the perioperative period. Recent Findings Synbiotics and fermented foods may have an even greater anti-inflammatory effect than probiotics or prebiotics alone. Recent data suggest that the anti-inflammatory effects and microbiome changes brought on by prebiotics, probiotics, and synbiotics have the potential to improve surgical outcomes. We highlight the potential to alter systemic inflammation, surgical and hospital-acquired infections, colorectal cancer formation, recurrence, and anastomotic leak. Synbiotics could also impact metabolic syndrome. Summary Prebiotics, probiotics, and especially synbiotics may be extremely beneficial when taken in the perioperative period. Even short-term gut microbiome pre-habilitation could alter surgical outcomes significantly.

show abstract

Perioperative oral care can prevent surgical site infection after colorectal cancer surgery: A multicenter, retrospective study of 1,926 cases analyzed by propensity score matching

Cited by 17 publications

References 33 publications

Number of Bacteria in Saliva in the Perioperative Period and Factors Associated with Increased Numbers

Number of Bacteria in Saliva in the Perioperative Period and Factors Associated with Increased Numbers

Implication of serum and salivary albumin tests in the recent oral health related epidemiological studies: A narrative review

Synbiotics and Surgery: Can Prebiotics and Probiotics Affect Inflammatory Surgical Outcomes?

Contact Info

Product

Resources

About