Perioperative Monitoring with Rotational Thromboelastometry in a Severe Hemophilia A Patient Undergoing Elective Ankle Surgery

Šimurda, Tomáš; Drotarova, Miroslava; Škorňová, Ingrid; Dobrotová, Miroslava; Brunclíková, Monika; Nečas, Libor; Cibula, Zoltán; Kubisz, Peter; Staško, J.

doi:10.1055/s-0043-57009

Cited by 1 publication

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“…This was emphasised by a German survey which showed that 86% of adults and 66% of children and adolescents experienced episodes of pain [ 3 ]. In addition to episodes of bleeding-related pain, PwH also experience pain associated with inflammation and multiarticular joint degeneration, with non-reversible end-stage haemophilic arthropathy [ 4 ]. Therefore, haemophilia can be considered as a chronic musculoskeletal disorder.…”

Section: Introductionmentioning

confidence: 99%

The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study

Foubert,

Roussel,

Chantrain

et al. 2023

Biomedicines

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In people with haemophilia (PwH), joint pain is a major comorbidity that is often overlooked and under-treated. It is believed that, to ensure the most successful outcome, pain management should be tailored to the predominant pain phenotype (i.e., nociceptive, neuropathic and nociplastic). The 2021 clinical criteria and grading system for nociplastic pain, established by the International Association for the Study of Pain (IASP), emphasize the necessity of early-stage identification and predominant pain type classification. Consistent with findings in other chronic musculoskeletal pain conditions, studies suggest that a subgroup of PwH suffers from nociplastic pain, i.e., pain arising from altered nociception rather than structural damage, but this has not yet been explored in PwH. This study aimed to identify PwH with “unlikely”, “possible” and “probable” nociplastic pain and investigate differences in anthropometric, demographic and clinical characteristics and psychological factors between subgroups of PwH and healthy individuals.: The IASP clinical criteria and grading system were used to classify pain types in adult men with moderate or severe haemophilia recruited from two Belgian haemophilia treatment centres. Statistical analyses were applied to study between-subgroup differences. Of 94 PwH, 80 PwH (85%) were classified with “unlikely” and 14 (15%) with “at least possible” nociplastic pain (including 5 PwH (5%) with “possible” and 9 PwH (10%) with “probable” nociplastic pain). PwH in both the “unlikely” and “at least possible” nociplastic pain groups showed significantly higher levels of unhelpful psychological factors compared to healthy individuals. Additionally, age may partially account for the observed differences in body height and psychological factors. Larger sample sizes may be needed to detect more subtle between-group differences. study confirmed the presence of nociplastic pain in haemophilia, categorising a notable subgroup as individuals who experience at least possible nociplastic pain. These exploratory insights may provide a starting point for future studies and the development of more effective and tailored pain management.

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Section: Introductionmentioning

confidence: 99%

The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study

Foubert,

Roussel,

Chantrain

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

Perioperative Monitoring with Rotational Thromboelastometry in a Severe Hemophilia A Patient Undergoing Elective Ankle Surgery

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Cited by 1 publication

References 12 publications

The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study

The Classification of Suspected Predominant Nociplastic Pain in People with Moderate and Severe Haemophilia: A Secondary Exploratory Study

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