Perioperative management of von Willebrand disease: a review for the anesthesiologist

Mazzeffi, Michael; Stone, Marc E.

doi:10.1016/j.jclinane.2011.02.003

Cited by 91 publications

(12 citation statements)

References 56 publications

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“…This increased risk of postoperative bleeding after a surgical procedure, justifies a close collaboration between hematologists and oral surgeons before planning electives surgical interventions. Thus, a specific hemostatic protocol can be determined for each patient and each procedure [ 2 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…injection. Finally, therapies enhancing alternative prothrombotic pathways or decreasing fibrinolysis, without substantially altering the plasma concentration of vWF might be used in some specific situations [ 2 , 4 ]. These treatments could be administered together or separately depending on the type and severity of vWD [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Among these numerous bleeding symptoms, these patients suffer from frequent bleedings located in the oral mucosa and dental management requires a close collaboration between hematologists and oral surgeons [ 2 , 4 - 6 ]. The amount and severity of bleedings depend on the type of the vWD, both local and systemic patient factors (such as periodontal inflammation, vasculopathy or platelet dysfunction) and surgical-related factors.…”

Section: Introductionmentioning

confidence: 99%

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Guided Implant Surgery to Reduce Morbidity in Von Willebrand Disease Patients: A Case Report

Fénelon¹,

Castet²,

Fricain

et al. 2018

TODENTJ

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Introduction:Von Willebrand Disease is the most common inherited bleeding disorder. In the general population, 1/8000 patients are affected. Primary hemostasis (platelet adhesion) and coagulation (protection of Factor VIII) are altered. Among several bleeding symptoms, these patients suffer from excessive bleeding of oral mucosa and dental management requires a close collaboration between haematologists and oral surgeons.Materials & Methods:Guided implant surgery can be used to increase the accuracy of implant placement and to reduce the overall morbidity of this surgical procedure by using a flapless surgery technique.Case Report:We report the case of a 49 years old woman having a Type 2A von Willebrand disease and who presented to replace tooth #.46 because of interradicular fracture and peri-apical infection. After planning the implant surgery using Codiagnostix® software, a surgical guide was prepared. The patient received 4 injections of von Willebrand factor (Willfactin®) for this particular surgical procedure. The implant was placed immediately after tooth removal and local haemostasis was performed.Discussion:The follow-up was uneventful and the implant was restored by a crown 4 months later. Two cases of implant placement in haemophiliac patients have been reported before in the literature.Conclusion:As far as we know, this is the first case report of implant placement in a patient having a von Willebrand disease. The use of guided surgery allowed to perform a mini-invasive procedure and thus contributed to prevent bleeding complications in this patient.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Guided Implant Surgery to Reduce Morbidity in Von Willebrand Disease Patients: A Case Report

Fénelon¹,

Castet²,

Fricain

et al. 2018

TODENTJ

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“…B. Gingko, [24]). Eine ebenfalls häufige Ursache einer Störung der primären Hämostase ist das (meist angeborene) Willebrand-Syndrom [19]. Seltener ist mit einer erworbenen Form des Willebrand-Syndroms zu rechnen, beispielsweise bei Aortenstenosen, künstlichen Aortenklappen oder im Rahmen eines multiplen Myeloms [27].…”

Section: Präoperative Gerinnungsdiagnostikunclassified

“…Abhängig vom verwendeten Aktivator kann wahlweise der Aspirineffekt (Aktivator: Arachidonsäu-re) oder der Clopidogreleffekt (Aktivator: ADP) erfasst werden. Die besondere Bedeutung dieser Methoden liegt allerdings in der postoperativen Erfassung einer potenziellen Aspirin-oder Clopidogrelresistenz [19,21].…”

Section: Präoperative Gerinnungsdiagnostikunclassified

Aktuelle Gerinnungsdiagnostik in der Intensivmedizin

Lang¹

2011

Med Klin

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In the preoperative setting, a standardized questionnaire on bleeding history cannot be replaced by the Quick test or activated partial thromboplastin time (APTT) measurement. Thrombelastometry provides rapid measurement of coagulation in the intra- and postoperative settings. Besides the Quick test and APTT, thrombelastometry provides information about clot firmness and clot stability. This allows goal-directed management in coagulopathy, which results in a reduction of transfusion of blood products. Furthermore, this can lead to not only an overall reduced length of stay in the hospital, but also in the intensive care unit, thus, contributing to a significant cost reduction.

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Review of von Willebrand Disease and Perioperative Management in Dentistry

Szumita

2018

Hemostasis in Dentistry

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Perioperative management of von Willebrand disease: a review for the anesthesiologist

Cited by 91 publications

References 56 publications

Guided Implant Surgery to Reduce Morbidity in Von Willebrand Disease Patients: A Case Report

Guided Implant Surgery to Reduce Morbidity in Von Willebrand Disease Patients: A Case Report

Aktuelle Gerinnungsdiagnostik in der Intensivmedizin

Review of von Willebrand Disease and Perioperative Management in Dentistry

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