“…Unpublished studies in the form of dissertations and theses were included to reduce publication bias (Trespidi, Barbui, & Cipriani, ). Studies were excluded if they (1) involved patients with trauma or rheumatoid arthritis as the conditions were known to differ in pathogenesis, prognosis, and management from OA (Krause & Matteson, ; Sohail, Anesti, Hanna, Khan, & Malik, ), (2) duplicated publications or publications using replicated patient data, and/or (3) secondary research and/or commentaries, editorials, expert opinions, and books. Uncertain cases were discussed with the second reviewer, A.J.Q.T., to achieve consensus for article inclusion.…”