Perioperative Indicators of Stress Response and Postoperative Inflammatory Complications in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery  A Prospective Observational Study

Song, Suk-Won; Yi, Gijong; Lee, Sak; Youn, Young‐Nam; Sul, Soon-Young; Yoo, Kyung-Jong

doi:10.1253/circj.cj-08-0291

Cited by 16 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[23][24][25] In our trial, WBC count and CRP concentration rose continuously to maximum concentrations on postoperative days 2 and 3, respectively, and were showing a trend toward baseline levels by postoperative day 4. Conversely, fibrinogen levels declined on postoperative day 1 before continuously rising through postoperative day 4.…”

Section: Baseline and Postoperative Values For Inflammatory Mediators Asupporting

confidence: 50%

Effect of ascorbic acid on inflammatory markers after cardiothoracic surgery

Colby

Chen

Baker

et al. 2011

American Journal of Health-System Pharmacy

View full text Add to dashboard Cite

show abstract

Section: Baseline and Postoperative Values For Inflammatory Mediators Asupporting

confidence: 50%

Effect of ascorbic acid on inflammatory markers after cardiothoracic surgery

Colby

Chen

Baker

et al. 2011

American Journal of Health-System Pharmacy

View full text Add to dashboard Cite

show abstract

“…So, it has predicted role that it's preoperative elevation as correlation with high morbidity and mortality rate. Patients undergoing heart surgery under CPB frequently experience systemic reactions that causes postoperative morbidity and prolonged hospital stay [8]. Some studies demonstrated increased preoperative levels of CRP and adverse events [10]- [13].…”

Section: Discussionmentioning

confidence: 99%

“…CRP is a plasma active reactant phase protein (normal: 0 -5 mg/L) that increases approximately in every type of inflammation and returns rapidly to normal level in recovery time [8]. In various studies, specificity and sensitivity of test had been evaluated in diagnosis and management of diseases.…”

Section: Introductionmentioning

confidence: 99%

The Association between Preoperative Plasma C-Reactive Protein (CRP) Level and Postoperative Adult Heart Surgery Outcome

Bilehjani¹,

Fakhari²,

Farzin³

et al. 2016

OJIM

View full text Add to dashboard Cite

Introduction: Careful history and physical examinations are the best ways for preoperative evaluation. Currently, we are recommended to rely on doing them rather than unnecessary and costly laboratory tests for confirmation or diagnosis of disease. The aim of study is the survey of CRP level association to decide further evaluation and expert consultation, newly diagnosed problems and possible effect on postoperative mortality and morbidity. Methods and Materials: In a descriptive retrospective study, hospital documentation of 620 patients older than 18 years undergone heart surgery in Tabriz Shahid Madani hospital was evaluated. Addition to plasma CRP level, patient's demographic information, type of surgery, preoperative significant tests, delay time in surgery start time after anesthesiology visit, cause of requested specialty consultation and treatment recommendation, postoperative complications and mortality rate were recorded and analyzed. Patients were classified according to preoperative plasma CRP level to five groups as negative, +1, +2, +3 and not measured (i.e. they considered as normal (0 -5 mg/l), mildly (5 -40 mg/l), moderately (40 -200 mg/L) or severely increased (>200 mg/l) groups). Results: Of 620 patients, 402 were male and 218 were female. There was not statistically significant correlation among demographic variables (gender, age, weight, and height), heart disease diagnosis and the type of surgery in five groups. In 79 individuals, they were done specialty consultations that most common of them were neurology consultation because of impaired renal laboratory tests. Only 2 cases were due to high CRP level. In any of cases, this preoperative consultation didn't result from new disease cases. CRP plasma level hadn't association with preoperative red blood cell sedimentation level. Prevalence of preoperative acute myocardium infarction was higher in * Corresponding author. B. Eissa et al. 94patients with high CRP level. In group +1, delay time was lower than other groups. The most common causes were cardiac causes. There wasn't statistically significant correlation between CRP level and different postoperative complications. There wasn't significant association between ICU stay time and postoperative hospital stay time and plasma high CRP level. Conclusion: Probably, plasma CRP level increases before surgery in acute myocardial infarction and results in high mortality rate. It seems that routine measurement of CRP in candidates for heart operation is beneficial for mortality rate prediction, so its increasing level can't help to diagnosis newly cases and it isn't prudent to consult with specialist.

show abstract

“…This can be particularly challenging in patients undergoing cardiothoracic surgery especially in those who are exposed to extracorporeal circulation. Patients undergoing cardiopulmonary bypass (CPB) often experience profound physiologic responses to the extracorporeal circulation with alterations in the hypothalamic-pituitary-adrenal access as well as activation of the inflammatory system [16,17]. Glucocorticoids are required for normal cardiovascular reactivity to angiotensin II, epinephrine, and norepinephrine [12].…”

Section: Discussionmentioning

confidence: 99%