Perioperative exercise training for patients with gastrointestinal cancer undergoing surgery: A systematic review and meta-analysis

Thomsen, Simon Nørskov; Mørup, Stine Truel; Mau-Sørensen, Morten; Sillesen, Martin; Lahart, Ian; Christensen, Jesper

doi:10.1016/j.ejso.2021.07.007

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…We aimed to randomize a total of 60 participants. In a systematic review performed prior to initiation of the trial [28], we identify no prior trials to inform a statistical power analysis, and no formal sample size calculation were performed to inform the target sample size. Instead, the sample size of 60 participants was based on 1) the local context (i.e., expected number of patients being treated in the department and concurrent trials recruiting the same patient population), 2)…”

Section: Sample Size Calculationmentioning

confidence: 99%

Postoperative exercise training in patients with colorectal liver metastases undergoing surgery (ELMA): a protocol for a randomized controlled trial

Thomsen,

Simonsen,

Christensen

2023

Preprint

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Section: Sample Size Calculationmentioning

confidence: 99%

Postoperative exercise training in patients with colorectal liver metastases undergoing surgery (ELMA): a protocol for a randomized controlled trial

Thomsen,

Simonsen,

Christensen

2023

Preprint

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“…

Gastrointestinal cancer is the most common malignant cancer encountered clinically, it not only reduces the quality of life of patients and increases the burden of caregivers, but also harms patients' mental health and increases patients' suffering and a serious threat to human health [1,2]. Surgery is the most effective method for treating gastrointestinal cancer [3].

…”

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confidence: 99%

Application and evaluation of a nurse-directed prehabilitation intervention program in patients with gastrointestinal cancer: A randomized intervention study

2023

JCIMCR

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“…While the prehabilitation concept appears promising, there is conflicting scientific evidence for its effectiveness. [5][6][7][8][9] Several RCTs have been performed, showing different effects of multimodal prehabilitation, ranging from meaningful changes in postoperative functional walking capacity and significantly improved postoperative clinical outcomes, 10,11 to no effect on postoperative outcomes. 12 Because these RCTs are usually performed under ideal circumstances, including only a selected group of patients, this can compromise external validity.…”

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confidence: 99%

Improved Postoperative Outcomes after Prehabilitation for Colorectal Cancer Surgery in Older Patients: An Emulated Target Trial

et al. 2022

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Background The aim of this study was to assess the effect of a multimodal prehabilitation program on perioperative outcomes in colorectal cancer patients with a higher postoperative complication risk, using an emulated target trial (ETT) design. Patients and Methods An ETT design including overlap weighting based on propensity score was performed. The study consisted of all patients with newly diagnosed colorectal cancer (2016–2021), in a large nonacademic training hospital, who were candidate to elective colorectal cancer surgery and had a higher risk for postoperative complications defined by: age ≥ 65 years and or American Society of Anesthesiologists score III/IV. Intention-to-treat (ITT) and per-protocol analyses were performed to evaluate the effect of prehabilitation compared with usual care on perioperative complications and length of stay (LOS). Results Two hundred fifty-one patients were included: 128 in the usual care group and 123 patients in the prehabilitation group. In the ITT analysis, the number needed to treat to reduce one or more complications in one person was 4.2 (95% CI 2.6–10). Compared with patients in the usual care group, patients undergoing prehabilitation had a 55% lower comprehensive complication score (95% CI −71 to −32%). There was a 33% reduction (95% CI −44 to −18%) in LOS from 7 to 5 days. Conclusions This study showed a clinically relevant reduction of complications and LOS after multimodal prehabilitation in patients undergoing colorectal cancer surgery with a higher postoperative complication risk. The study methodology used may serve as an example for further larger multicenter comparative effectiveness research on prehabilitation.

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Perioperative exercise training for patients with gastrointestinal cancer undergoing surgery: A systematic review and meta-analysis

Cited by 6 publications

References 45 publications

Postoperative exercise training in patients with colorectal liver metastases undergoing surgery (ELMA): a protocol for a randomized controlled trial

Postoperative exercise training in patients with colorectal liver metastases undergoing surgery (ELMA): a protocol for a randomized controlled trial

Application and evaluation of a nurse-directed prehabilitation intervention program in patients with gastrointestinal cancer: A randomized intervention study

Improved Postoperative Outcomes after Prehabilitation for Colorectal Cancer Surgery in Older Patients: An Emulated Target Trial

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