Perioperative enteral supplementation with glutamine, fiber, and oligosaccharide reduces early postoperative surgical stress following esophagectomy for esophageal cancer

T, Abe; Hosoi, Takahiro; Kawai, Ryosuke; Uemura, Naomi; Higaki, Eiji; An, Byonggu; Kawakami, Jiro; Saito, Takuya; Shimizu, Yasuhiro

doi:10.1007/s10388-018-0630-z

Cited by 12 publications

(8 citation statements)

References 34 publications

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“…The thoracotomy was found to be able to cause intense stress responses proportionate to both visceral damage and skin incision pain. 19 Previous study found that wound infiltration with local anesthetics could block parietal afferent signals from incision injury. 20 However, it was deemed to have weak inhibiting effect on the afferent noxious stimuli from visceral pain caused by surgical operation.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Ultrasound-guided Erector Spinae Plane Block and Wound Infiltration on Perioperative Opioid Consumption and Postoperative Pain in Thoracotomy

Wang¹,

Zhang²,

Wei³

et al. 2019

J Coll Physicians Surg Pak

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Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Ultrasound-guided Erector Spinae Plane Block and Wound Infiltration on Perioperative Opioid Consumption and Postoperative Pain in Thoracotomy

Wang¹,

Zhang²,

Wei³

et al. 2019

J Coll Physicians Surg Pak

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“…Details of perioperative management have been described previously. 21 An immune-enhancing diet (IMPACT Ò ) was given orally for 5 days before surgery. After surgery, patients were extubated in the operating room.…”

Section: Surgical Procedures and Perioperative Managementmentioning

confidence: 99%

Significance of Antimicrobial Prophylaxis for the Prevention of Early-Onset Pneumonia After Radical Esophageal Cancer Resection: A Retrospective Analysis of 356 Patients Undergoing Thoracoscopic Esophagectomy

Higaki

Fujieda

et al. 2021

Ann Surg Oncol

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Background. Postoperative pneumonia is a common complication after esophagectomy and is associated with a high mortality rate. Although many randomized, controlled trials have been conducted on the prevention of postoperative pneumonia, little attention has been paid to the efficacy of antimicrobial prophylaxis. The purpose of this study was to investigate the impact of antimicrobial prophylaxis on the prevention of postoperative pneumonia. Methods. Data of patients with esophageal cancer who underwent thoracoscopic esophagectomy between 2016 and 2020 were collected. Early-period patients received cefazolin (CEZ) per protocol as antimicrobial prophylaxis (n = 250), and later-period patients received ampicillin/sulbactam (ABPC/SBT) (n = 106) because of the unavailability of CEZ in Japan. The incidence of pneumonia was compared between treatments in this quasiexperimental setting. Pneumonia detected by routine computed tomography (CT) on postoperative Days 5-6 was defined as early-onset pneumonia, and pneumonia that developed later was defined as late-onset pneumonia.Results. The incidence of early-onset pneumonia was significantly lower (3.8% vs. 13.6%, P = 0.006), and the median length of postoperative hospital stay was significantly shorter (17 vs. 20 days, P \ 0.001) in the ABPC/ SBT group than in the CEZ group. The incidence of lateonset pneumonia was similar between groups (9.4% vs. 10.0%, P = 0.870). The incidence of Clostridioides difficile infections and the incidence of multidrug-resistant organisms were similar between groups. Multivariate analyses consistently showed the superiority of ABPC/SBT to CEZ in preventing early-onset pneumonia (odds ratio: 0.20, P = 0.006). Conclusions. ABPC/SBT after esophagectomy was better at preventing early-onset pneumonia compared with CEZ and was feasible regarding the development of antimicrobial resistance.

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“…14 Therefore, some researchers suggest that patients with severe brain injury should be given supplementary glutamine at an early stage. [15][16][17] Studies have discovered that both glutamine and lowdose amino acids have the potential to activate autophagy. 18 Besides, the effect of autophagy explains that preserving (or minimizing) early nutrition may be more beneficial to critically ill patients.…”

Section: Discussionmentioning

confidence: 99%

Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury

Xiong

Qian

2021

NDT

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Perioperative enteral supplementation with glutamine, fiber, and oligosaccharide reduces early postoperative surgical stress following esophagectomy for esophageal cancer

Cited by 12 publications

References 34 publications

Comparison of the Effects of Ultrasound-guided Erector Spinae Plane Block and Wound Infiltration on Perioperative Opioid Consumption and Postoperative Pain in Thoracotomy

Comparison of the Effects of Ultrasound-guided Erector Spinae Plane Block and Wound Infiltration on Perioperative Opioid Consumption and Postoperative Pain in Thoracotomy

Significance of Antimicrobial Prophylaxis for the Prevention of Early-Onset Pneumonia After Radical Esophageal Cancer Resection: A Retrospective Analysis of 356 Patients Undergoing Thoracoscopic Esophagectomy

Low-Protein, Hypocaloric Nutrition with Glutamine versus Full-Feeding in the Acute Phase in ICU Patients with Severe Traumatic Brain Injury

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