Perioperative Detection of Circulating Tumor Cells in Radical or Partial Nephrectomy for Renal Cell Carcinoma

Haga, Nobuhiro; Onagi, Akifumi; Koguchi, Tomoyuki; Hoshi, Seiji; Ogawa, Soichiro; Akaihata, Hidenori; Hata, Junya; Hiraki, Hiroyuki; Honda, Ryumon; Tanji, Ryo; Matsuoka, Kanako; Kataoka, Masao; Sato, Yuichi; Ishibashi, Keiichiro; Kojima, Yoshiyuki

doi:10.1245/s10434-019-08127-8

Cited by 21 publications

(21 citation statements)

References 30 publications

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“…Haga et al compared four surgical approaches: laparoscopic RN, laparoscopic PN, open RN and open PN. They found that open RN resulted in significantly higher postoperative CTC counts than laparoscopic RN or open or laparoscopic PN [ 28 ]. Our data showed a tendency for the RN group to have a higher positive rate of CTCs and more preoperative CTC counts than the PN group.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of circulating tumour cells and Ki-67 in renal cell carcinoma

Song

Dong

et al. 2021

World J Surg Onc

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Background Renal cell carcinoma (RCC) is a common malignant tumour of the genitourinary system. We aimed to analyse the potential value of metastasis-related biomarkers, circulating tumour cells (CTCs) and the proliferative marker Ki-67 in the diagnosis of RCC. Methods Data from 24 laparoscopic radical nephrectomies (RNs) and 17 laparoscopic partial nephrectomies (PNs) were collected in 2018. The numbers and positive rates of CTCs and circulating tumour microemboli (CTM) in the peripheral blood were obtained at three different time points: just before surgery, immediately after surgery and 1 week after surgery. Ki-67 protein expression was evaluated in the RCC tissue by immunohistochemistry. Results Except for the statistically significant association between the preoperative CTC counts and tumour size, no association between the number and positive rate of perioperative CTCs and clinicopathological features was found. The CTC counts gradually decreased during the perioperative period, and at 1 week after surgery, they were significantly lower than those before surgery. High Ki-67 expression was significantly positively correlated with preoperative CTC counts. In addition, Ki-67 expression was higher in the high CTC group (≥ 5 CTCs). Conclusion Our results suggest that surgical nephrectomy is associated with a decrease in CTC counts in RCC patients. CTCs can act as a potential biomarker for the diagnosis and prognosis of RCC. A careful and sufficient long-term follow-up is needed for patients with high preoperative CTC counts.

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Section: Discussionmentioning

confidence: 99%

Clinical significance of circulating tumour cells and Ki-67 in renal cell carcinoma

Song

Dong

et al. 2021

World J Surg Onc

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“…According to the literature, different surgical methods may affect periopretive CTC counts. Haga et al 28 group. Our data suggested that the RN group showed a tendency to have higher positive rate of CTCs and more preoperative CTC counts than PN group.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Circulating Tumor Cells and Ki-67 in Renal Cell Carcinoma

Song

Dong

et al. 2021

Preprint

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Background: Renal cell carcinoma (RCC) is a common maligant tumor of the genitourinary system. We aimed to analyze the potential value of the metastasis-related biomarker, circulating tumor cells (CTCs) and proliferative marker Ki-67 in diagnosis of RCC. Methods: Data from 24 laparoscopic radical nephrectomy (RN) and 17 laparoscopic partial nephrectomy (PN) were collected in 2018. The number and positive rate of CTCs and circulating tumor microemboli (CTM) was obtained at three different time points in peripheral blood just before, immediately and one week after surgery. Ki-67 protein expression was evaluated in RCC tissue by immunohistochemistry. Results: No association between the number and positive rate of perioprative CTC and clinicopathological features was found, except for the statistically significant association between the preoprative CTC counts and tumor size. The CTC counts gradually decreased during the perioperative period, and at one week after surgery was significantly lower than that before surgery. Higher Ki-67 expression was signiﬁcantly correlated positively with preoprative CTC counts. In addition, a higher Ki-67 express has been found in high CTCs group (CTCs ≥ 5). Conclusion: Our results suggest that surgical nephrectomy is associated with a decrease in CTC counts of RCC patients. CTCs can act as a potential biomarker for the diagnosis and prognostic of RCC. Careful and sufﬁcient long-term follow-up is needed for patients with high preoprative CTC counts.

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“…In addition, a perioperative prospective detection of CTCs in 60 RCC patients treated with different surgical modalities was recently published. The authors found a significantly greater number of CTCs after open radical nephrectomy (RN) than after laparoscopic procedures, confirmed performing a multivariate analysis, thus speculating the need for more stringent clinical monitoring after RN [ 95 ]. A molecular characterization of CTCs collected from 10 metastatic RCC patients as a post hoc analysis from the TARIBO trial [ 96 ] was recently published.…”

Section: Renal Cell Carcinomamentioning

confidence: 94%

Update on Circulating Tumor Cells in Genitourinary Tumors with Focus on Prostate Cancer

Cimadamore

Aurilio

Nolè

et al. 2020

Cells

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Current developments in the treatment of genitourinary tumors underline the unmet clinical need for biomarkers to improve decision-making in a challenging clinical setting. The detection of circulating tumor cells (CTCs) has become one of the most exciting and important new approaches to identifying biomarkers at different stages of disease in a non-invasive way. Potential applications of CTCs include monitoring treatment efficacy and early detection of progression, selecting tailored therapies, as well as saving treatment costs. However, despite the promising implementation of CTCs in a clinical scenario, the isolation and characterization of these cells for molecular studies remain expensive with contemporary platforms, and significant technical challenges still need to be overcome. This updated, critical review focuses on the state of CTCs in patients with genitourinary tumor with focus on prostate cancer, discussing technical issues, main clinical results and hypothesizing potential future perspectives in clinical scenarios.

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Perioperative Detection of Circulating Tumor Cells in Radical or Partial Nephrectomy for Renal Cell Carcinoma

Cited by 21 publications

References 30 publications

Clinical significance of circulating tumour cells and Ki-67 in renal cell carcinoma

Clinical significance of circulating tumour cells and Ki-67 in renal cell carcinoma

Clinical Significance of Circulating Tumor Cells and Ki-67 in Renal Cell Carcinoma

Update on Circulating Tumor Cells in Genitourinary Tumors with Focus on Prostate Cancer

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