Perioperative chemotherapy versus surgery alone for resectable colorectal liver metastases: an international multicentre propensity score matched analysis on long-term outcomes according to established prognostic risk scores

Martino, Marcello Di; Primavesi, Florian; Syn, Nicholas; Dorcaratto, Dimitri; Rodríguez, Ángela de la Hoz; Dupré, Aurélien; Piardi, Tullio; Rhaiem, Rami; Blanco‐Fernández, Gerardo; Villaverde, A. Prada; Sanjuán, Juan Carlos Rodríguez; Santiago, Roberto; Fernández-Moreno, M.C.; Ferret, Georgina; Ben, Santiago López; Muñóz, Miguel Ángel Suárez; Pérez-Alonso, Alejandro J.; Koh, Ye‐Xin; Jones, Robert; Martín-Pérez, Elena

doi:10.1016/j.hpb.2021.04.026

Cited by 9 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the authors also reflect on the difficulty to define high risk of recurrence, and the great heterogeneity of the studies included. By contrast, Di Martino et al, published a retrospective multicenter study in 2021, which rather counter-intuitively suggests that perioperative chemotherapy may prolong overall survival in patients with resectable CRLM in whom there is a low risk of recurrence [23].…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy in patients with a solitary colorectal liver metastasis – A nationwide propensity score matched study

Frühling

Urdzik

Isaksson

2022

European Journal of Surgical Oncology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Chemotherapy in patients with a solitary colorectal liver metastasis – A nationwide propensity score matched study

Frühling

Urdzik

Isaksson

2022

European Journal of Surgical Oncology

View full text Add to dashboard Cite

“…Subsequent external validation by international, multi-institutional cohorts has demonstrated strong calibration of the GAME score and higher discrimination than the CRS and m-CS [35,36]. The GAME score has also been used as a part of a risk stratification framework in observational studies to assess treatment strategies in resectable CRLM [37].…”

Section: Margonis Et Al Developed the Genetic And Morphological Evalu...mentioning

confidence: 99%

Prognostic Models Incorporating RAS Mutation to Predict Survival in Patients with Colorectal Liver Metastases: A Narrative Review

Wong

Diakos

Molloy

et al. 2022

Cancers

View full text Add to dashboard Cite

Recurrence and survival vary widely among patients who undergo curative-intent resection of colorectal liver metastases (CRLM). Prognostic models provide estimated probabilities of these outcomes and allow the effects of multiple potentially interacting variables to be adjusted and assessed simultaneously. Although many prognostic models based on clinicopathologic factors have been developed since the 1990s to predict survival after resection of CRLM, these models vary in their predictive performance when applied to contemporary cohorts. Rat sarcoma viral oncogene homolog (RAS) mutation status is routinely tested in patients with metastatic colorectal cancer to predict response to anti-epidermal growth factor therapy. In addition, mutations in RAS predict survival and recurrence in patients undergoing hepatectomy for CRLM. Several recent prognostic models have incorporated RAS mutation status as a surrogate of tumor biology and combined revised clinicopathologic variables to improve the prediction of recurrence and survival. This narrative review aims to evaluate the differences between contemporary prognostic models incorporating RAS mutation status and their clinical applicability in patients considered for curative-intent resection of CRLM.

show abstract

“…Surgery and systemic therapy are mainstream treatments for gastric cancer, and curative treatment with surgical resection is possible for patients with localized disease ( 2 ). However, for the remaining patients with inoperable or metastatic gastric cancer, combination chemotherapy (including 5-fluorouracil (5-FU)-based regimens) has become the first line of systemic treatment, based on the findings of randomized phase III trials ( 3 - 5 ). Unfortunately, most advanced-stage patients are resistant to this conventional chemotherapy, and their prognosis remains poor, with a 5-year relative survival rate of 6% ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

USP14 inhibition regulates tumorigenesis by inducing apoptosis in gastric cancer

Lee

Kim

Lee

2023

BMB Rep

View full text Add to dashboard Cite

Deubiquitinases (DUBs) are an essential component of the ubiquitin-proteasome system (UPS). They trim ubiquitin from substrate proteins, thereby preventing them from degradation, and modulate different cellular processes. Ubiquitin-specific protease 14 (USP14) is a DUB that has mainly been studied for its role in tumorigenesis in several cancers. In the present study, we found that the protein levels of USP14 were remarkably higher in gastric cancer tissues than in the adjacent normal tissues. We also demonstrated that the inhibition of USP14 activity using IU1 (an USP14 inhibitor) or the inhibition of USP14 expression using USP14-specific siRNA markedly reduced the viability of gastric cancer cells and suppressed their migratory and invasive abilities. The reduction in gastric cancer cell proliferation due to the inhibition of USP14 activity was a result of the increase in the degree of apoptosis, as evidenced by the increased expression levels of cleaved caspase-3 and cleaved PARP. Furthermore, an experiment using the USP14 inhibitor IU1 revealed that the inhibition of USP14 activity suppressed 5-fluorouracil (5-FU) resistance in GC cells. Collectively, these findings indicate that USP14 plays critical roles in gastric cancer progression and suggest its potential to serve as a novel therapeutic target for gastric cancer treatment. [BMB Reports 2023; 56(8): 451-456]

show abstract

Perioperative chemotherapy versus surgery alone for resectable colorectal liver metastases: an international multicentre propensity score matched analysis on long-term outcomes according to established prognostic risk scores

Cited by 9 publications

References 31 publications

Chemotherapy in patients with a solitary colorectal liver metastasis – A nationwide propensity score matched study

Chemotherapy in patients with a solitary colorectal liver metastasis – A nationwide propensity score matched study

Prognostic Models Incorporating RAS Mutation to Predict Survival in Patients with Colorectal Liver Metastases: A Narrative Review

USP14 inhibition regulates tumorigenesis by inducing apoptosis in gastric cancer

Contact Info

Product

Resources

About