Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus

Impact of the Siewert Classification on the Outcome of Patients Treated by Preoperative Chemoradiotherapy for a Nonmetastatic Adenocarcinoma of the Oesophagogastric Junction

“…The other prognostic factors found significant in multivariate analysis for ORR in this study were in concordance with other published data in particular age [ 22 ], tumor size [ 5 ], and nodal status [ 23 ].…”

Impact of the Siewert Classification on the Outcome of Patients Treated by Preoperative Chemoradiotherapy for a Nonmetastatic Adenocarcinoma of the Oesophagogastric Junction

“…The other prognostic factors found significant in multivariate analysis for ORR in this study were in concordance with other published data in particular age [ 22 ], tumor size [ 5 ], and nodal status [ 23 ].…”

Preoperative Chemoradiotherapy vs Chemotherapy for Adenocarcinoma of the Esophagogastric Junction

“…Previous meta-analyses included both patients with AEG and esophageal squamous cell carcinoma, 5 , 48 , 49 only 1 of the 2 modalities preoperative chemotherapy or CRT, 50 or studies using chemotherapy as well as those using CRT without being able to compare the 2 modalities by integrating direct and indirect evidence in an NMA. 7 , 13 , 51 In line with our results, they consistently showed the advantage of preoperative CRT plus surgery or preoperative and/or perioperative chemotherapy plus surgery over surgery alone with regard to survival and surrogate outcomes like downstaging and complete resection. 5 , 7 , 13 , 47 , 48 , 50 Postoperative morbidity and mortality were also assessed, and no relevant differences between the modalities were found.…”

“… 7 , 13 , 51 In line with our results, they consistently showed the advantage of preoperative CRT plus surgery or preoperative and/or perioperative chemotherapy plus surgery over surgery alone with regard to survival and surrogate outcomes like downstaging and complete resection. 5 , 7 , 13 , 47 , 48 , 50 Postoperative morbidity and mortality were also assessed, and no relevant differences between the modalities were found. One meta-analysis 51 exclusively assessed safety and found no differences between preoperative therapy plus surgery and surgery alone but did not include data pertaining only to patients with AEG.…”

Outcome evaluation of ECF, DCF, FOLFOX, and FLOT chemotherapy regimens as perioperative treatment in elderly patients with resectable gastric cancer; A retrospective comparative study

“…In addition, the results of multivariate analysis showed the significant effects of age, performance status, and tumor site on survival. [ 36 ] Our results confirmed that R0 resection has a significantly lower HR for death compared to R1 resection. Nevertheless, other predictors that were significant in the univariate analysis were insignificant in the multivariate analysis, possibly due to the smaller sample size.…”

Impact of the Siewert Classification on the Outcome of Patients Treated by Preoperative Chemoradiotherapy for a Nonmetastatic Adenocarcinoma of the Oesophagogastric Junction

“…The other prognostic factors found significant in multivariate analysis for ORR in this study were in concordance with other published data in particular age [ 22 ], tumor size [ 5 ], and nodal status [ 23 ].…”

Preoperative Chemoradiotherapy vs Chemotherapy for Adenocarcinoma of the Esophagogastric Junction

“…Previous meta-analyses included both patients with AEG and esophageal squamous cell carcinoma, 5 , 48 , 49 only 1 of the 2 modalities preoperative chemotherapy or CRT, 50 or studies using chemotherapy as well as those using CRT without being able to compare the 2 modalities by integrating direct and indirect evidence in an NMA. 7 , 13 , 51 In line with our results, they consistently showed the advantage of preoperative CRT plus surgery or preoperative and/or perioperative chemotherapy plus surgery over surgery alone with regard to survival and surrogate outcomes like downstaging and complete resection. 5 , 7 , 13 , 47 , 48 , 50 Postoperative morbidity and mortality were also assessed, and no relevant differences between the modalities were found.…”

“… 7 , 13 , 51 In line with our results, they consistently showed the advantage of preoperative CRT plus surgery or preoperative and/or perioperative chemotherapy plus surgery over surgery alone with regard to survival and surrogate outcomes like downstaging and complete resection. 5 , 7 , 13 , 47 , 48 , 50 Postoperative morbidity and mortality were also assessed, and no relevant differences between the modalities were found. One meta-analysis 51 exclusively assessed safety and found no differences between preoperative therapy plus surgery and surgery alone but did not include data pertaining only to patients with AEG.…”

Outcome evaluation of ECF, DCF, FOLFOX, and FLOT chemotherapy regimens as perioperative treatment in elderly patients with resectable gastric cancer; A retrospective comparative study

“…In addition, the results of multivariate analysis showed the significant effects of age, performance status, and tumor site on survival. [ 36 ] Our results confirmed that R0 resection has a significantly lower HR for death compared to R1 resection. Nevertheless, other predictors that were significant in the univariate analysis were insignificant in the multivariate analysis, possibly due to the smaller sample size.…”

Impact of the Siewert Classification on the Outcome of Patients Treated by Preoperative Chemoradiotherapy for a Nonmetastatic Adenocarcinoma of the Oesophagogastric Junction

“…The other prognostic factors found significant in multivariate analysis for ORR in this study were in concordance with other published data in particular age [ 22 ], tumor size [ 5 ], and nodal status [ 23 ].…”

Preoperative Chemoradiotherapy vs Chemotherapy for Adenocarcinoma of the Esophagogastric Junction

“…Previous meta-analyses included both patients with AEG and esophageal squamous cell carcinoma, 5 , 48 , 49 only 1 of the 2 modalities preoperative chemotherapy or CRT, 50 or studies using chemotherapy as well as those using CRT without being able to compare the 2 modalities by integrating direct and indirect evidence in an NMA. 7 , 13 , 51 In line with our results, they consistently showed the advantage of preoperative CRT plus surgery or preoperative and/or perioperative chemotherapy plus surgery over surgery alone with regard to survival and surrogate outcomes like downstaging and complete resection. 5 , 7 , 13 , 47 , 48 , 50 Postoperative morbidity and mortality were also assessed, and no relevant differences between the modalities were found.…”

“… 7 , 13 , 51 In line with our results, they consistently showed the advantage of preoperative CRT plus surgery or preoperative and/or perioperative chemotherapy plus surgery over surgery alone with regard to survival and surrogate outcomes like downstaging and complete resection. 5 , 7 , 13 , 47 , 48 , 50 Postoperative morbidity and mortality were also assessed, and no relevant differences between the modalities were found. One meta-analysis 51 exclusively assessed safety and found no differences between preoperative therapy plus surgery and surgery alone but did not include data pertaining only to patients with AEG.…”

Outcome evaluation of ECF, DCF, FOLFOX, and FLOT chemotherapy regimens as perioperative treatment in elderly patients with resectable gastric cancer; A retrospective comparative study

“…In addition, the results of multivariate analysis showed the significant effects of age, performance status, and tumor site on survival. [ 36 ] Our results confirmed that R0 resection has a significantly lower HR for death compared to R1 resection. Nevertheless, other predictors that were significant in the univariate analysis were insignificant in the multivariate analysis, possibly due to the smaller sample size.…”