Perioperative Changes of Colon Microbiocenosis in Patients With Colon Cancer

Bagnenko, S. F.; Zakharenko, A. A.; Suvorov, A. N.; Шлык, И. В.; Ten, O. A.; Dzhamilov, S. R.; Belyaev, M. A.; Trushin, Anton; Natkha, Aleksandr; Зайцев, Д. А.; Vovin, Kirill; Rybalchenko, Vitaliy

doi:10.24884/0042-4625-2016-175-6-33-37

“…Patients receiving autoprobiotics, compared to the control group, reported fewer postoperative complaints, as validated by the GIS for dyspepsia assessment and the GSRS for gastroenterological complaints. Improving the clinical data and stool frequency and form correspond to the results described when using probiotics by other authors in the treatment of oncological diseases [53,54]. Positive changes by the GSRS questionnaire in group A patients underscore the high efficacy of autoprobiotics in preventing postoperative stool disorders and dyspepsia in CRC patients.…”

Section: Discussionsupporting

confidence: 78%

“…Analysis of the frequency and consistency of stool before treatment showed that in patients with CRC with tumor localization in the left flank, there are stool disorders of both diarrhea (25% of patients) and constipation (25% of patients); in 50% of patients, there were no stool disorders. Analysis of the appearance of the first independent stool after surgery showed that individuals receiving an autoprobiotic had an independent stool of normal consistency (3-4 types on the Bristol scale) earlier than those who did not receive it (the stool was either 1-2 types, or 5-6 types on the Bristol scale [53,54]), and also against the background of rapid normalization of stool frequency, there was a low severity of flatulence in group A. Patients who took the treatment with autoprobiotics had a hospital stay of 5-7 days post-surgery, signifying the absence of postoperative complications.…”

Section: Clinical Datamentioning

confidence: 99%

Autoprobiotics in the Treatment of Patients with Colorectal Cancer in the Early Postoperative Period

Ermolenko,

Baryshnikova,

Alekhina

et al. 2024

Microorganisms

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Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics, remains relevant. The aim of this study is to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of Enterococcus faecium and Enterococcus hirae as a personalized functional food product (PFFP) in the complex therapy of colorectal cancer (CRC) in the early postoperative period. A total of 36 patients diagnosed with CRC were enrolled in the study. Study group A comprised 24 CRC patients who received autoprobiotic therapy in the early postoperative period, while the control group C included 12 CRC patients without autoprobiotic therapy. Prior to surgery and between days 14 and 16 post-surgery, comprehensive evaluations were conducted on all patients, encompassing the following: stool and gastroenterological complaints analysis, examination of the gut microbiota (bacteriological study, quantitative polymerase chain reaction, metagenome analysis), and analysis of interleukins in the serum. Results: The use of autoprobiotics led to a decrease in dyspeptic complaints after surgery. It was also associated with the absence of postoperative complications, did not cause any side effects, and led to a decrease in the level of pro-inflammatory cytokines (IL-6 and IL-18) in the blood serum. The use of autoprobiotics led to positive changes in the structure of escherichia and enterococci populations, the elimination of Parvomonas micra and Fusobacterium nucleatum, and a decrease in the quantitative content of Clostridium perfringens and Akkermansia muciniphila. Metagenomic analysis (16S rRNA) revealed an increase in alpha diversity. Conclusion: The introduction of autoprobiotics in the postoperative period is a highly effective and safe approach in the complex treatment of CRC. Future studies will allow the discovery of additional fine mechanisms of autoprobiotic therapy and its impact on the digestive, immune, endocrine, and neural systems.

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“…Analysis of the appearance of the first independent stool after surgery showed that individuals receiving an autoprobiotic had an independent stool of normal consistency (3-4 types on the Bristol scale) earlier than those who did not receive it (the stool was either 1-2 types on the Bristol scale, or 5-6 types), and also against the background of rapid normalization of stool frequency, there were low severity of flatulence in group A. This corresponded to the results described when using probiotics by other authors in the treatment of oncological diseases [43,44].…”

Section: Clinical Datasupporting

confidence: 87%

Autoprobiotics in the treatment of patients with colorectal cancer in the early postoperative period

Ermolenko,

Baryshnikova,

Alekhina

et al. 2024

Preprint

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Introduction: Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics remains relevant. The aim of the study: to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of Enterococcus faecium and Enterococcus hirae in the complex therapy of colorectal cancer (CRC) in the early postoperative period. Materials and methods: A total of 36 patients diagnosed with CRC were enrolled in the study. The study group (Group A) comprised 24 CRC patients who received autoprobiotic therapy in the early postoperative period, while the control group (Group C) included 12 CRC patients without autoprobiotic therapy.Prior to surgery and between days 14-16 post-surgery, comprehensive evaluations were conducted on all patients, encompassing the following: stool and gastroenterological complains analysis. examination of the gut microbiota (bacteriological study, quantitative polymerase chain reaction, metagenome analysis), analysis of interleukins in serum. Results: The use of autoprobiotics led to decrease dyspeptic complaints after surgery, was associated with absence of postoperative complications, did not cause side effects, led to a decrease in the level of pro-inflammatory cytokines (IL-6 and IL-18) in the blood serum. The use of autoprobiotics led to positive changes in the structure of escherichia and enterococci populations, the elimination of Parvomonas micra, Fusobacterium nucleatum, decrease in the quantitative content of Clostridium perfringens, Akkermansia muciniphila. Metagenomic analysis (16S rRNA) revealed an increase in alpha diversity. Conclusion: The administration of autoprobiotics in the postoperative period is highly effective and safe in the comprehensive treatment of colorectal cancer patients. Future studies will allow the discovery of additional fine mechanisms of autoprobiotic therapy and its impact on the digestive, immune, endocrine and neural systems.

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“…По литературным данным, у всех пациентов с КРР возникают существенные сдвиги в кишечном микробиоценозе. Оперативное вмешательство с использованием антибактериальных препаратов приводит, как правило, к еще более тяжелым последствиям, проявляющимися в существенном изменении клинико-лабораторных показателей и состава микробиоты, которые создают предпосылки к таким серьезным осложнениям, как абдоминальный сепсис, псевдомембранозный колит, антибиотикоассоциированные дисбиозы и колиты [44][45][46].…”

Section: результаты исследования 1 клинико-лабораторные данныеunclassified

Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

Ermolenko,

Alyokhina,

Kashchenko

et al. 2024

jour

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Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics, remains relevant. The aim of the study was to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of Enterococcus faecium and E. hirae in the complex therapy of colorectal cancer (CRC) in the early postoperative period. The use of autoprobiotics did not cause side effects and led to a decrease in the level of pro-inflammatory cytokines (IL-6 and IL-18) in the blood serum. The features of the intestinal microbiome in patients with CRC were revealed, which are fundamentally different from those of other authors by an increase in alpha- biodiversity, lactobacilli, bifidobacteria, Bacteroides thetaiotaomicron and its additional differences associated with the absence of non-pathogenic enterococci: a greater amount of Parvimonas micra, a smaller amount of Akkermansia spp., an increase in the content of Klebsiella sp., Fusobacterium nucleatum and Clostridium perfringens. The use of autoprobiotics led to the elimination of P. micra, a decrease in C. perfringens, which led to the normalization of the microbiota in most patients. The effectiveness of autoprobiotics in the treatment of CRC has been proven, which, apparently, is associated with a change in the composition of intestinal microbiocenosis.

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Perioperative Changes of Colon Microbiocenosis in Patients With Colon Cancer

Cited by 4 publications

References 2 publications

Autoprobiotics in the Treatment of Patients with Colorectal Cancer in the Early Postoperative Period

Autoprobiotics in the Treatment of Patients with Colorectal Cancer in the Early Postoperative Period

Autoprobiotics in the treatment of patients with colorectal cancer in the early postoperative period

Gut microbiota in the combined treatment of colorectal cancer using autoprobiotics

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