“…When interruption of OAC is required, bridging does not seem to be beneficial, except in patients with mechanical heart valves: In a randomized trial of 1884 patients with AF, interruption of anticoagulation was non-inferior to heparin bridging for the outcome of arterial thrombo-embolism (incidence of 0.4% and 0.3%, respectively) and resulted in a lower risk of major bleeding (1.3% and 3.2%, respectively). 502 OAC interruptions should be minimized to prevent stroke. 9.6 Management of bleeding events in anticoagulated patients with atrial fibrillation 9.6.1 Management of minor, moderate, and severe bleeding General assessment of an anticoagulated patient with AF experiencing a bleeding event should include the assessment of bleeding site, onset, and severity of the bleeding, the time-point of last intake of OAC and other antithrombotic drugs, and other factors influencing bleeding risk such as CKD, alcohol abuse, and concurrent medications.…”