Perioperative Antibiotic Regimen in Rats Treated With Pamidronate Plus Dexamethasone and Subjected to Dental Extraction: A Study of the Changes in the Jaws

López‐Jornet, Pía; Camacho-Alonso, Fabio; Martinez-Canovas, Ascensión; Molina‐Miñano, Francisco; Gómez-García, Francisco; Vicente-Ortega, Vicente

doi:10.1016/j.joms.2011.02.059

Cited by 43 publications

(28 citation statements)

References 30 publications

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“…[9,10] Although it can develop spontaneously, most of the studies reported that surgical procedures are the main comorbidity factor. [9,10,12] The frequency of ONJ caused by tooth extraction in patients who received IV BPs was determined as 40%À80%. [19] The experiment was designed in order to mimic extraction socket healing in oncology patients receiving IV BPs.…”

Section: Resultsmentioning

confidence: 99%

“…[9] Tooth extraction can induce bacterial invasion to the expose bone, and infection has a crucial role in maintaining these types of the lesion. [10] Recently, it has been shown that immediate mucoperiostal coverage of the extraction socket can reduce the risk of ONJ and have good results in the early stage of ONJ. [11] Doxycycline is a broad-spectrum antibiotic, active against gram-positive and gram-negative organisms.…”

Section: Introductionmentioning

confidence: 99%

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Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Duygu

Sapmaz-Metin

Kütan

et al. 2016

Biotechnology & Biotechnological Equipment

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The aim of this study is to investigate the effect of doxycycline collagen sponge on bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the level of serum biomarkers as an indicator of osteonecrosis. Twenty-four rats were divided into four groups. Animals in the control group were injected with saline and animals in Groups I, II and III were injected with zoledronate three times a week for eight weeks. After eight weeks, the following procedures were performed in each group. In Group I: extraction of maxillary first molar, in Group II: extraction of maxillary first molar and mucoperiosteal coverage was performed and in Group III: extraction of maxillary first molar and mucoperiosteal coverage with doxycycline collagen sponges was performed. At the end of 16 weeks, all animals were sacrificed. Serum collagen type I C-telopeptide (CTx), tartrate-resistant acid phosphatase (TRACP 5b) and alkaline phosphatase (ALP) levels' analysis, clinical examination, histological and histomorphometrical analysis were performed. As a result no significant difference in CTx, TRACP 5b and ALP levels was observed between groups. Complete mucosal healing was observed in all animals in the control group and 66.7% of animals in Group III. The necrotic bone area in Group III was significantly lower than the other groups (p < 0.01). Statistically significant difference was observed between groups in terms of detached osteoclast number (p < 0.01). In conclusion, local application of doxycycline could have a positive effect in reducing the risk of BRONJ in rats.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Duygu

Sapmaz-Metin

Kütan

et al. 2016

Biotechnology & Biotechnological Equipment

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“…However, experimental induction and manipulation of disease progression does not always reflect clinical reality. To that effect, several ONJ animal models utilize extraction of healthy teeth [21, 24, 25, 27–30], which are rarely extracted in ONJ patients. Similarly, ONJ animal models utilizing periodontitis [20, 22, 26] employ experimental procedures that depict some, but not necessarily all the components of the pathological process of human periodontal disease [40].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous osteonecrosis of the jaws in the maxilla of mice on antiresorptive treatment: A novel ONJ mouse model

Molon

Cheong

Bezouglaia

et al. 2014

Bone

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Although osteonecrosis of the jaws (ONJ), a serious complication of antiresorptive medications, was reported a decade ago, the exact mechanisms of disease pathophysiology remain elusive. ONJ-like lesions can be induced in animals after antiresorptive treatment and experimental interventions such as tooth extraction or periapical or periodontal disease. However, experimental induction and manipulation of disease progression does not always reflect clinical reality. Interestingly, naturally occurring maxillofacial abscesses, inducing aggressive inflammation of the peri-radicular mucosa with significant osteolysis and alveolar bone expansion, have been reported in mice. Here, we aimed to explore whether osteonecrotic lesions would develop in areas of maxillary peri-radicular infections, in mice on antiresorptive medications with distinct pharmacologic action, thus establishing a novel ONJ animal model. Mice were treated with RANK-Fc or OPG-Fc that bind to RANKL or with the potent bisphosphonate zoledronic acid (ZA). Maxillae were assessed radiographically and histologically. μCT imaging of vehicle mice revealed several maxillae with altered alveolar bone morphology, significant ridge expansion and large lytic areas. However, in RANK-Fc, OPG-Fc and ZA treated animals the extent of bone loss was significantly less, but exuberant bone deposition was noted at the ridge periphery. BV and BV/TV were increased in the diseased site of antiresorptive vs. veh animals. Histologically, extensive inflammation, bone resorption and marginal gingival epithelium migration were seen in the diseased site of vehicle animals. Rank-Fc, OPG-Fc and ZA reduced alveolar bone loss, increased periosteal bone formation, and induced areas of osteonecrosis, and bone exposure that in many animals covered significant part of the alveolar bone. Collectively, our data demonstrate ONJ-like lesions at sites of maxillary peri-radicular infection, indistinguishable in mice treated with RAKL inhibitors vs. zoledronate. This novel mouse model of spontaneous ONJ supports a central role of osteoclast inhibition and infection/inflammation in ONJ pathogenesis and validates and complements existing animal models employing experimental interventions.

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“…Antibiotics can prevent the development of ONJ-like lesions in a rat model [56]. One hundred twenty animals underwent tooth extraction and received combination of dexamethasone and pamidronate during different time periods.…”

Section: Discussionmentioning

confidence: 99%

Bisphosphonate Associated Osteonecrosis of the Jaw: An Update on Pathophysiology, Risk Factors, and Treatment

Rasmusson

Abtahi

2014

International Journal of Dentistry

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Osteonecrosis of the jaw in patients treated with bisphosphonates is a relatively rare but well known complication at maxillofacial units around the world. It has been speculated that the medication, especially long-term i.v. bisphosphonate treatment, could cause sterile necrosis of the jaws. The aim of this narrative review of the literature was to elaborate on the pathological mechanisms behind the condition and also to gather an update on incidence, risk factors, and treatment of bisphosphonate associated osteonecrosis of the jaw. In total, ninety-one articles were reviewed. All were published in internationally recognized journals with referee systems. We can conclude that necrotic lesions in the jaw seem to be following upon exposure of bone, for example, after tooth extractions, while other interventions like implant placement do not increase the risk of osteonecrosis. Since exposure to the bacterial environment in the oral cavity seems essential for the development of necrotic lesions, we believe that the condition is in fact chronic osteomyelitis and should be treated accordingly.

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Perioperative Antibiotic Regimen in Rats Treated With Pamidronate Plus Dexamethasone and Subjected to Dental Extraction: A Study of the Changes in the Jaws

Cited by 43 publications

References 30 publications

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Spontaneous osteonecrosis of the jaws in the maxilla of mice on antiresorptive treatment: A novel ONJ mouse model

Bisphosphonate Associated Osteonecrosis of the Jaw: An Update on Pathophysiology, Risk Factors, and Treatment

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