Perioperative anaphylaxis: A five-year review in a tertiary paediatric hospital

Abstract

Making a diagnosis of perioperative anaphylaxis and identifying culprit drugs are diagnostic challenges. The aim of this study is to describe the perioperative presentation of anaphylaxis and results of patients who underwent allergy evaluation. This is a retrospective review of perioperative anaphylaxis of severity Grade 2 and above based on the Australian and New Zealand Anaesthetic Allergy Group criteria from 2015 to 2019 in a tertiary paediatric hospital. Data collected were demographics, clinical features, investigations and management. Of the 35,361 cases of paediatric anaesthesia, there were 15 cases of perioperative anaphylaxis, giving an incidence of four in 10,000. The median age was seven years (interquartile range four–15 years) with a male predominance of 86.7% (13/15). The severity of anaphylaxis was Grade 2 in 33.3% (5/15) and Grade 3 in 66.7% (10/15). The commonest presenting feature was hypotension (13/15, 86.7%) while the earliest symptom was respiratory change (9/15, 60.0%). Dynamic tryptase was raised in 75% (6/8) of the patients with adequate tryptase samples. Eight patients (53.3%) completed allergy testing, of whom five patients (62.5%) had IgE-mediated anaphylaxis with skin test positive to cefazolin ( n = 3), atracurium ( n = 1) and rocuronium ( n = 1). Three patients (25.0%) had non–IgE-mediated reactions with negative skin tests. Although only half the patients completed allergy evaluation, a culprit drug could be identified in 62.5%, with antibiotics being the commonest. This emphasises the need for appropriate evaluation in cases of suspected perioperative anaphylaxis.

Cerebrospinal Fluid Cutaneous Fistula Following Neuraxial Anesthesia for Cesarean Delivery

“…Testing for the presence of beta-2 transferrin would be a more specific and sensitive approach, as it is a protein found only in the CSF and perilymph [6]. However, this is a time-consuming and expensive method and, therefore, not always requested [4][5][6][7]. Due to the rarity of this clinical situation, there is no standardized treatment or formal recommendations.…”

Anaphylaxis mortality in the perioperative setting: Epidemiology, elicitors, risk factors and knowledge gaps

“…Fatal PA appears to be more frequent in adults than in children 4,16–19 . Females have been reported to have a 3‐fold increased risk of developing anaphylaxis in the perioperative setting, regardless of severity and PA elicitors 20,21 .…”

“…15 Fatal PA appears to be more frequent in adults than in children. 4,[16][17][18][19] Females have been reported to have a 3-fold increased risk of developing anaphylaxis in the perioperative setting, regardless of severity and PA elicitors. 20,21 In France, in a cohort of 1247 severe (grades 3 and 4) NMBA anaphylaxis cases, 63.6% of non-fatal cases occurred in females, whereas 62.2% of fatal cases were in males (p < 10 −4 ).…”