Periodontopathogens and human β‐defensin‐2 expression in gingival crevicular fluid from patients with periodontal disease in Guangxi, China

Yong, Xiangzhi; Chen, Y.; Tao, Renchuan; Zeng, Qiu-ling; Liu, Z.; Jiang, Longfeng; Ye, L.; Lin, Xiang

doi:10.1111/jre.12220

Cited by 18 publications

(27 citation statements)

References 40 publications

(62 reference statements)

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“…Albeit nonstatistically significant, hBD-1 and hBD-2 levels were slightly lower in patients with a PSR/CPITN index of 3 and 4 when compared to those with a PSR/CPITN index of 1 and 2. We believe this small reduction in hBD-1 and hBD-2 levels in the saliva occurred due to the degradation of hBD by proteases released at sites that are more commonly affected by periodontopathogens, as hypothesized by Yong et al 27 who verified higher hBD-2 levels in the saliva of patients with gingivitis than among those with periodontitis. Another possible explanation to this reduction could be the lower average number of teeth in Group 3.…”

Section: Discussionmentioning

confidence: 63%

“…The quantification of hBD-1 and hBD-2 by ELISA has been widely used for the determination of salivary levels of these peptides. 14,26 There are conflicting reports in the current literature regarding hBD-1 and hBD-2 expression in periodontal disease, as some studies suggest upregulated hBD expression 8,14,27,28 whereas some suggest a down regulated expression of this peptide. 29,30 In addition, previous studies found high concentrations of these peptides only after stimulation with periodonto pathogens.…”

Section: Discussionmentioning

confidence: 99%

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Influence of periodontal condition on levels of human beta defensins 1 and 2 in saliva

Komesu¹,

Ribeiro²,

Lourenço³

et al. 2018

JMEN

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Many research studies have looked into periodontal disease biomarkers. The aim of this study was to assess salivary levels of human beta defensin 1 and 2 (hBD-1) and (hBD-2) in different periodontal condition. The Periodontal Screening & Recording (PSR) system, a modification of de Community Periodontal Index Treatment Needs (CPITN), was used to evaluate the periodontal treatment needs of 120 patients without any systemic disease. Salivary levels of hBD-1 and hBD-2 were determined by ELISA. Higher hBD-1 levels were detected in the saliva of patients with a PSR/CPITN index of 3 and 4 (7,363±2,837pg/ mL) and in those with a PSR/CPITN index of 1 and 2 (7,750±3,477pg/mL) when compared to patients without periodontal disease, with a PSR/CPITN index of 0 (5,644±2,747pg/ mL; P=0.013). As with hBD-1, hBD2 levels were also higher in the saliva of patients with a PSR/CPITN index of 3 and 4 (310±98pg/mL) and a PSR/CPITN index of 1 and 2 (318±85pg/mL) when compared to patients with a PSR/CPITN index of 0 (251±87pg/mL; P=0.011). In conclusion, compared to patients without periodontal disease, PSR/CPITN index 0, we verified higher salivary concentrations of hBD-1 and hBD-2 in patients with some degree of periodontal detected by PSR/CPITN between 1 and 4.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Influence of periodontal condition on levels of human beta defensins 1 and 2 in saliva

Komesu¹,

Ribeiro²,

Lourenço³

et al. 2018

JMEN

View full text Add to dashboard Cite

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“…This has also been shown by Kumar et al (42). The fact that all types of bacteria studied could be detected, even in healthy controls, might indicate that the presence of periodontal pathogens does not necessarily lead to periodontal diseases (1). However, these species show just a small percentage of whole bacteria, and the open-ended approach of their study may not be geared to indicate an association of this species with the disease (20).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported a strong association between the presence of P. gingivalis and periodontitis, but did not find any association between the presence of P. gingivalis and gingivitis (1,12,44,45). Although a number of putative bacteria are considered to be associated with chronic periodontitis, it has become clear that other factors are involved in the etiology of several types of periodontitis.…”

Section: Discussionmentioning

confidence: 99%

“…Periodontal diseases are complicated oral diseases, which are specified by bacterial-induced inflammatory destruction of tooth-supporting tissues (1). Periodontal diseases can be described as one of the predominant polymicrobial infections of humans, which can advance and lead to gum retrogression, soft tissue harm, weakness of the bone, eventual osteoporosis and tooth loss (severe periodontitis).…”

Section: Introductionmentioning

confidence: 99%

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Study of Porphyromonas gingivalis in periodontal diseases: A systematic review and meta-analysis

Rafiei

Kiani

Sayehmiri

et al. 2017

Med. J. Islam. Republic Iran

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Background: The mouth cavity hosts various types of anaerobic bacteria including Porphyromonas gingivalis, which causes periodontal inflammatory diseases. P. gingivalis is a gram-negative oral anaerobe and is considered as a main etiological factor in periodontal diseases. Several studies have reported a relationship between P. gingivalis in individuals with periodontal diseases and a critical role of this bacterium in the pathogenesis of periodontal diseases. The present study aimed at estimating this probability using a meta-analysis.Methods: We searched several databases including PubMed, Scopus, Google Scholar, and Web of Science to identify case-control studies addressing the relationship between P. gingivalis with periodontal diseases. A total of 49 reports published from different countries from 1993 to 2014 were included in this study. I² (heterogeneity index) statistics were calculated to examine heterogeneity. Data were analyzed using STATA Version 11.Results: After a detailed analysis of the selected articles, 49 case-control studies with 5924 individuals fulfilled the inclusion criteria for the meta-analysis. The healthy controls included 2600 healthy individuals with a Mean±SD age of 36.56±7.45 years. The periodontal diseases group included 3356 patients with a mean age of 43.62±8.35 years. There was a statistically significant difference between P. gingivalis in periodontal patients and healthy controls; 9.24 (95% CI: 5.78 to 14.77; P = 0.000). In the other word, there was a significant relationship between the presence of P. gingivalis and periodontal diseases.Conclusion: Analyzing the results of the present study, we found a strong association between the presence of P. gingivalis and periodontal diseases. This result suggests that another research is needed to further assess this subject.

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β-defensin 2 synthesized by a cell-free protein synthesis system and encapsulated in liposomes inhibits adhesion of Porphyromonas gingivalis to oral epithelial cells

Hiroshima

Kido

et al. 2023

Odontology

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Periodontopathogens and human β‐defensin‐2 expression in gingival crevicular fluid from patients with periodontal disease in Guangxi, China

Cited by 18 publications

References 40 publications

Influence of periodontal condition on levels of human beta defensins 1 and 2 in saliva

Influence of periodontal condition on levels of human beta defensins 1 and 2 in saliva

Study of Porphyromonas gingivalis in periodontal diseases: A systematic review and meta-analysis

β-defensin 2 synthesized by a cell-free protein synthesis system and encapsulated in liposomes inhibits adhesion of Porphyromonas gingivalis to oral epithelial cells

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