Periodontopathogens: a new view. Systematic review. Part 1

Abstract

Relevance. The modern view of periodontitis as a dysbiotic disease that occurs as a result of changes in the microbial composition of the subgingival region is considered in a systematic review. Purpose. To study a new paradigm of development of generalized periodontitis. Materials and methods. Randomized controlled trials (RCTS) were selected for the study, including cluster RCTS, controlled (non-randomized) microbiological and clinical studies of the oral microbiome in adult patients with generalized periodontitis over the past 10 years. Results. The development of periodontal dysbiosis occurs over a period of time, which slowly turns the symbiotic association of the host and microbe into a pathogenic one. This review examines the current paradigm of periodontitis progression, which calls into question the traditional concept of a disease induced by several particular periodontal pathogens belonging to the red complex.Conclusions. As follows from modern literature periodontitis is to a certain extent caused by the transition from a harmonious symbiotic bacterial community to a dysbiotic one. Recent scientific studies have shown that not single microorganism is not able to cause disease but the microbial community as a whole leads to the development of pathology.