Periodontitis Response to Anti-TNF Therapy in Ankylosing Spondylitis

Fabri, Gisele Maria Campos; Pereira, Rosa Maria Rodrigues; Savioli, Cynthia; Saad, Carla G. S.; Moraes, José Reinaldo da Silva Cabral de; Siqueira, José Tadeu Tesseroli de; Bonfá, Eloísa

doi:10.1097/rhu.0000000000000300

Cited by 27 publications

(31 citation statements)

References 29 publications

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“…Savioli et al . could not find modifications in the periodontal parameters at 6 months in patients with RA under anti‐TNF‐α, whereas Fabri et al . registered a positive effect on the periodontium at 6 months in patients with AS and on anti‐TNF‐α, but not in patients with RA.…”

Section: Resultsmentioning

confidence: 93%

“…Quality of information in non‐randomized clinical studies was considered high level in seven articles and moderate in the remaining studies . Quality of information in the In vivo animal studies was considered moderate in five articles and high in seven studies .…”

Section: Resultsmentioning

confidence: 99%

“…The overall results of our research tend to support this hypothesis. The majority of clinical studies, and two animal studies, show that BMs lead to the clinical improvement in the systemic disease as well as in P and AP. This finding suggests that cytokine‐targeted therapies might exert a positive effect on the periodontal conditions in patients with autoimmune inflammatory diseases and altered levels of inflammatory cytokines .…”

Section: Discussionmentioning

confidence: 99%

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Interaction of biologic therapy with apical periodontitis and periodontitis: a systematic review

Peddis

Musu

Ideo

et al. 2019

Australian Dental Journal

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Biologic medications (BMs) are increasingly used for the management of systemic chronic inflammatory diseases. These diseases are often associated with a higher prevalence of apical periodontitis (AP) and periodontitis (P). The purpose of this systematic review was to ascertain the interactions between AP and/or P and BMs. The review was registered in the PROSPERO database (CRD42017054756). Electronic searches were performed on Pubmed Medline, Scopus and The Web of Science from their inception through to 20 March 2018. The references of the articles selected were checked. The keywords were chosen based on a pilot search, which aimed to find the most frequently prescribed BMs. The included studies were appraised qualitatively using appropriate tools. Thirty-five articles met the inclusion criteria, comprising 16 non-randomized clinical studies, 12 in vivo animal studies and 7 case reports. Quality of information was assessed as high in 18 articles, moderate in 16 articles and low in 1 article. BMs in patients suffering from chronic inflammatory diseases seems to inhibit the progression of AP and P, and to enhance the healing response to periodontal and endodontic treatment. A healthier condition of the periodontal tissues seems to be associated with a better response of the patient to BMs therapy.Abbreviations and acronyms: AP = apical periodontitis; BM = biologic medications; P = periodontitis; RANKL = receptor activator of nuclear factor kappa-Β ligand (RANKL).

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Interaction of biologic therapy with apical periodontitis and periodontitis: a systematic review

Peddis

Musu

Ideo

et al. 2019

Australian Dental Journal

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“…RANKL blockade has been successful in animal models of periodontitis (180)(181)(182). Patients treated with anti-TNF-α therapy for other disorders have also shown some improvement in alveolar bone loss (183).…”

Section: Therapeutic Perspectivementioning

confidence: 99%

Inflammatory osteolysis: a conspiracy against bone

Mbalaviele¹,

Novack

Schett

et al. 2017

Journal of Clinical Investigation

180

171

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“…Interleukin (IL)-2, IL-6 and TNF-α are all raised in AS [85] as well as being implicated in periodontitis [86]. In fact, anti-TNF therapy in AS patients leads to a significant improvement in periodontal disease markers [87].…”

Section: Periodontitis and Ankylosing Spondylitismentioning

confidence: 99%

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

Rutter-Locher¹,

Fuggle²,

Orlandi³

et al. 2017

Periodontitis - A Useful Reference

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The oral cavity is home to vast populations of commensal microbial organisms which constitute the 'healthy oral microbiome.' Periodontitis is a destructive, infectious, inflammatory condition affecting the gums. Initially, a biofilm structure develops, causing localized inflammation. This biofilm is then colonized by certain anaerobic bacteria, including the 'red complex' organisms. There is an increasing interest in the communication between these organisms and host immune surveillance, a dialog which may plays an important role in the development of autoimmune diseases. Studies have shown an association between periodontitis and other inflammatory conditions including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and systemic lupus. The advent of accessible 16S ribosomal sequencing has led to exciting developments in the characterization of the human microbiome and the ability to study this interaction in more detail. The transmucosal communication between periodontitis and host immunity may provide avenues of discovery regarding the etiology and progression of rheumatic diseases.

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Periodontitis Response to Anti-TNF Therapy in Ankylosing Spondylitis

Abstract: Patients with AS under anti-TNF improved periodontal attachment. The mechanism for this effect needs further studies.

Cited by 27 publications

References 29 publications

Interaction of biologic therapy with apical periodontitis and periodontitis: a systematic review

Interaction of biologic therapy with apical periodontitis and periodontitis: a systematic review

Inflammatory osteolysis: a conspiracy against bone

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

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