Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease

Abstract

Although periodontal infection does affect the concentration of hs-CRP and IL-6 in serum, a subgroup of patients exist who are highly susceptible to an increased risk of CHD associated with periodontitis, suggesting that there may be subjects who have an elevated risk of CHD independent of susceptibility to periodontal tissue destruction per se.

Relationship between Periodontal Disease (Periodontitis) and Acute Vascular Events a Case-Control Study Enperiva Study

“…Microorganisms that cause this condition, interleukins, cross-reacting antibodies, etc. are involved [15][16][17][18][19][20][21][22][23][24][25][26]; something similar happens with the physiopathogenesis of atheromatous disease [10]. It is necessary to demonstrate how these two diseases interact in order to study the clinical impact and the prognosis.…”

“…However, not all vascular events were related to those RF; during the last 15 years, POD has started to be regarded as a risk factor strongly associated with atheromatous disease [1][2][3][4][5][6][7][8][9][10][11][12]. Periodontal disease and atheromatous disease share not only risk factors such as smoking and diabetes, but also a complex multifactorial process of chronic inflammation stimulating mediators that accelerate endothelial dysfunction and/or mechanisms of cross-reacting antibodies against the periodontal flora and endothelial cell proteins; this may explain the relation between these pathologies [13][14][15]. The studies which have explored the association between these two diseases were published with different biases as regards the endpoints to determine this relation [16], the design, the population, the sample size and even the different definitions of periodontal disease [17,18].…”

Diagnostic Value of Acute Phase Proteins in Periodontal, Psychosomatic and Cardiometabolic Diseases: Response to Treatment

“…The efficacy of priodontal treatment in reducing these parameters is suggestive of common mediators in the progression of periodontal disease and metabolic syndrome, providing an effective therapeutic target. Other workers have also reported that serum levels of hsCRP and IL-6 are significantly higher in periodontitis patients with decreased levels following treatment (Yamazaki et al 2005;Nakajima et al 2010). However there was no significant association between TNF- levels and periodontitis.…”

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

“…IL-6 can promote coagulation and result in the development of atherosclerosis. The enhancement of IL-6 levels has been associated with both cardiovascular-risk and periodontal disease [27]. TNF-α stimulates the production of chemokines and cytokines, collagenase, prostaglandin E2 [28], cellular adhesion molecules and bone resorption-related factors.…”