Periodontitis and stroke: A Mendelian randomization study

C, Ma; Wu, Min; Gao, Jie; Liu, Chuanzi; Xie, Yi; Lv, Qiushi; Zhang, Xiaohao

doi:10.1002/brb3.2888

Cited by 14 publications

(7 citation statements)

References 42 publications

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“…Different populations have different genetic characteristics, and some genetic variations may be prevalent in one population but scarce or absent in another as a result of recent emergence and limited dissemination [ 27 , 28 ]. Hence, the generalizability of our results to other ethnic groups may be potentially limited, and this is also a common limitation in MR studies [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study

Zhang,

Hu,

Fang

et al. 2024

Neurol Ther

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Introduction Previous studies have reported controversial relationships between circulating vascular endothelial growth factors (VEGF) and ischemic stroke (IS). This study aims to demonstrate the causal effect between VEGF and IS using Mendelian randomization (MR). Methods Summary statistics data from two large-scale genome-wide association studies (GWAS) for 16,112 patients with measured VEGF levels and 40,585 patients with IS were downloaded from public databases and included in this study. A published calculator was adopted for MR power calculation. The primary outcome was any ischemic stroke, and the secondary outcomes were large-artery stroke, cardioembolic stroke, and small-vessel stroke. We used the inverse variance-weighted (IVW) method for primary analysis, supplemented by MR-Egger regression and the weighted median method. Results Nine SNPs were included to represent serum VEGF levels. The IVW method revealed no strong causal association between VEGF and any ischemic stroke (odds ratio [OR] 1.01, 95% CI 0.99–1.04, p = 0.39), cardioembolic stroke (OR 1.04, 95% CI 0.97–1.12, p = 0.28), large-artery stroke (OR 1.02, 95% CI 0.95–1.09, p = 0.62), and small-vessel stroke (OR 0.98, 95% CI 0.91–1.04, p = 0.46). These findings remained robust in sensitivity analyses. MR-Egger regression suggested no horizontal pleiotropy. Conclusions This Mendelian randomization study found no relationship between genetically predisposed serum VEGF levels and risks of IS or its subtypes. Supplementary Information The online version contains supplementary material available at 10.1007/s40120-024-00601-0.

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Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study

Zhang,

Hu,

Fang

et al. 2024

Neurol Ther

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“…In addition, unlike animal experiments, the MR method reduces the burden of random verification on humans and can demonstrate causality without putting participants at risk [55]. Several MR studies on stroke were previously performed with various results [19,[56][57][58][59]. Smoking behavior was a causal factor for ischemic stroke in an MR analysis [20], and another MR study showed that smoking, body mass index, and waist/hip ratio were causally associated with stroke [21].…”

Section: Discussionmentioning

confidence: 99%

Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study

Lee,

Seo

2023

Biomolecules

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Researchers have suggested a potential relationship between gamma-glutamyl transferase (GGT) level and stroke. We investigated a potential causal relationship between GGT level as exposures and stroke and stroke subtypes (cardioembolic, small vessel, and large artery) in a European population. We performed a two-sample Mendelian randomization (MR) study using the genome-wide association study (GWAS) data from the UK Biobank as the exposure set. For the outcome set, we used stroke in the GWAS data from the GIGASTROKE Consortium. We considered alcohol consumption, atrial fibrillation, and body mass index as confounders. We used PhenoScanner searches for removal of SNPs and multivariable MR analysis for assessing confounders. We observed significant causal associations between GGT level and stroke (odds ratio [OR] = 1.23, 95% CI = [1.05–1.44], and p = 0.012 with IVW; OR = 1.19, 95% CI= [1.02–1.39], and p = 0.031 with MR-PRESSO). These results were consistent after removing SNPs related to confounding factors. Similarly, in multivariable MR, GGT was associated with stroke after adjusting for confounding factors (OR = 1.30, 95% CI 1.07–1.60), p = 0.010). Because GGT level has a causal relationship with stroke, researchers should test its significance as a potential risk factor for stroke. Additional research is required to validate these results.

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“…Розвиток порушень мінерального обміну при агресивних формах пародонтиту у різних вікових групах потребує подальшого вивчення, при цьому, для розуміння можливих шляхів дослідження набувають актуальності дані, отримані молекулярними генетиками [22,23].…”

Section: епідеміологія і етіопатогенетичні фактори розвитку агресивни...unclassified

Epidemiology and Etiopathogenetic Factors of the Development of Aggressive Forms of Periodontitis

Bandrivska¹,

Lysokon²

2023

Ukr. ž. med. bìol. sportu

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The purpose of the work was to study the etiology and main etiopathological factors of the development of aggressive forms of periodontitis based on the analysis of additional pathogenetic aspects of mineral metabolism disorders according to modern literature. Materials and methods. The bibliosemantic method was used to clarify the state of the problem, study the analysis of the results of previous scientific research based on literature sources and electronic resources. Results. Periodontitis is the most widespread disease among all periodontal pathologies (chronic generalized periodontitis occurs in 90% of cases). Until recently, aggressive forms of periodontitis were not given due attention, since according to epidemiological studies by S. Renvert and M. Wikstom (1996), in the general structure of periodontal diseases, aggressive forms of periodontitis occur with a frequency of 5–10%. To understand the mechanisms of the development of aggressive forms of periodontitis, attention is paid to their development in children and adolescents. Clinical and radiological examinations of children and adolescents showed different frequency of aggressive forms of periodontitis (localized juvenile periodontitis and generalized juvenile periodontitis): in the USA – 2.27%, in Denmark – 0.1%, in Finland – 0.1%, in Nigeria – 0.8%, in Brazil – 0.3%, in England – 0.17%, in Chile – 0.32%. Studies have shown that aggressive forms of periodontitis are equally common in children and adolescents, regardless of gender. At the same time, localized juvenile periodontitis is 3 times more common in boys, not the same for girls. A new and rather promising vector of periodontology is the study of the role of juvenile changes in the bone skeleton on the development and course of periodontal diseases. The development of mineral metabolism disorders in aggressive forms of periodontitis in different age groups requires further study, while the data obtained by molecular geneticists become relevant for understanding the possible ways of research. Considering the fact that the jaw bones are a component of the skeleton, the strength of which can be affected by various exogenous and endogenous factors, in particular genetic ones, the main direction of searching for candidate sensitivity genes is conducted among the markers of bone metabolism disorders. Of many candidate genes that determine bone mineral density, the most well-known is the vitamin D receptor gene. Conclusion. The analysis of the available literature showed that the study of the role of mineral and bone metabolism disorders in the emergence and development of aggressive forms of periodontitis has a wide scientific perspective, and obtaining new data on the state of systemic regulatory factors and their effects on the local mechanisms of periodontal tissue damage will allow not only to improve the diagnosis of various forms, but also to increase the effectiveness of the treatment of this pathology

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Periodontitis and stroke: A Mendelian randomization study

Cited by 14 publications

References 42 publications

Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study

Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study

Potential Causal Association between Elevated Gamma-Glutamyl Transferase Level and Stroke: A Two-Sample Mendelian Randomization Study

Epidemiology and Etiopathogenetic Factors of the Development of Aggressive Forms of Periodontitis

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