Periodontitis and <scp>NAFLD</scp>‐related diseases: A bidirectional two‐sample Mendelian randomization study

Qiao, Feng; Li, Xiaoyan; Liu, Yuchang; Zhang, Shunming; Liu, Dayong; Li, Changyi

doi:10.1111/odi.14785

Cited by 5 publications

(2 citation statements)

References 58 publications

(74 reference statements)

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“…In light of the metaanalysis's conclusions, we applied the latest MR periodontitis genetic data to similarly obtain consistent conclusions. The recent MR study suggested that NAFLD moderately increases the chances of periodontitis by Li Tan et al However, we believe that both the exposure and outcome samples were derived from the FinnGen database, which goes against the premise of a two-sample MR study and makes the conclusions unreliable (39) (40).…”

Section: Discussionmentioning

confidence: 99%

Association between periodontitis and NAFLD-related diseases: Results from the NHANES and Mendelian randomization study

Huang,

Wang,

Wang

et al. 2024

Preprint

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Background & Aim There are contradictory causal links between disorders associated to non-alcoholic fatty liver and periodontitis. The purpose of this research is to use Mendelian randomization (MR) to establish a causal association between periodontitis and non-alcoholic fatty liver disease (NAFLD), including the latter's development to liver fibrosis. Materials and Methods The study included 4,425 people from the National Health and Nutrition Examination Survey (NHANES) conducted in the United States between 2009 and 2014. The study employed two multivariable logistic regression models to evaluate the correlation between advanced fibrosis (AF) and periodontitis, as well as NAFLD. Model 1 did not involve any covariate adjustments; model 2 controlled for age, gender, and race; model 3 was additionally adjusted for Body Mass Index (BMI), education level, household income poverty ratio, smoking status, physical activity, and history of diabetes. Periodontitis (n:17,353 cases/28,210 controls) was used as the exposure, and NAFLD (n:2,275 cases/375,002 controls), fibrosis (n:146 cases/373,307 controls), cirrhosis (n:1,142 cases/373,307 controls) and fibrosis/cirrhosis (n:1,841 cases/366, 450 cases control) as outcomes and causality validation was performed. Sensitivity studies, such as heterogeneity tests, multiple validity tests, and exclusion analyses, were also carried out to guarantee the trustworthiness of the findings. Results In the observational study, there was no significant correlation between periodontitis and NAFLD (OR: 0.82, 95% CI: 0.64–1.95) or AF (OR: 1.06, 95% CI: 0.72–1.56). The MR analysis found no significant association between genetically predicted periodontitis and liver conditions in the IVW method (NAFLD: OR: 1.12, 95% CI: 0.98 − 1.27; fibrosis: OR: 0.84, 95% CI: 0.50 − 1.42; cirrhosis: OR:0.99, 95% CI: 0.82 − 1.19; fibrosis/cirrhosis: OR: 0.92, 95% CI: 0.83 − 1.26). There is consistency in sensitivity results. Conclusions According to cross-sectional research, there is no discernible link between NAFLD or liver fibrosis and periodontal disease, and the MR analysis does not support a causal relationship between them.

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Section: Discussionmentioning

confidence: 99%

Association between periodontitis and NAFLD-related diseases: Results from the NHANES and Mendelian randomization study

Huang,

Wang,

Wang

et al. 2024

Preprint

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“…They concluded that down-regulation of APOH induces gut microbial disorders and exacerbates fatty liver, highlighting the role of APOH in fatty liver [ 125 ]. Notably, oral health, such as periodontitis, has been theorized to be linked to the development of MASLD [ 126 ]. In addition, emerging evidence suggests a relationship between oral and gut microorganisms [ 127 , 128 ].…”

Section: Gut Microbial Dysbiosis In Masldmentioning

confidence: 99%

Updated mechanisms of MASLD pathogenesis

Li,

Yang,

et al. 2024

Lipids Health Dis

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Metabolic dysfunction-associated steatotic liver disease (MASLD) has garnered considerable attention globally. Changing lifestyles, over-nutrition, and physical inactivity have promoted its development. MASLD is typically accompanied by obesity and is strongly linked to metabolic syndromes. Given that MASLD prevalence is on the rise, there is an urgent need to elucidate its pathogenesis. Hepatic lipid accumulation generally triggers lipotoxicity and induces MASLD or progress to metabolic dysfunction-associated steatohepatitis (MASH) by mediating endoplasmic reticulum stress, oxidative stress, organelle dysfunction, and ferroptosis. Recently, significant attention has been directed towards exploring the role of gut microbial dysbiosis in the development of MASLD, offering a novel therapeutic target for MASLD. Considering that there are no recognized pharmacological therapies due to the diversity of mechanisms involved in MASLD and the difficulty associated with undertaking clinical trials, potential targets in MASLD remain elusive. Thus, this article aimed to summarize and evaluate the prominent roles of lipotoxicity, ferroptosis, and gut microbes in the development of MASLD and the mechanisms underlying their effects. Furthermore, existing advances and challenges in the treatment of MASLD were outlined.

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Association between nonalcoholic fatty liver disease scores and chronic periodontitis: A retrospective cohort study

Joo,

Kang,

Moon

et al. 2024

Journal of Periodontology

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BackgroundAlthough several studies have demonstrated a bidirectional relationship between nonalcoholic fatty liver disease (NAFLD) and chronic periodontitis, few studies have reported that NAFLD causes chronic periodontitis, especially in the Asian population.MethodsThis study was conducted on 129,087 individuals, and the NAFLD score was assessed using the Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), and Framingham Steatosis Index (FSI). The incidence of chronic periodontitis was defined as a diagnostic code with dental procedures. Multi‐variable adjusted Cox proportional hazard regression analysis was performed with hazard ratio (HR) and 95% confidence intervals (CIs).ResultsNine thousand one hundred and twenty‐eight chronic periodontitis cases (7.1%) were identified during a mean 7.4 years follow‐up period. Each NAFLD score was related to chronic periodontitis. In the FLI score, HR and 95% CIs for the incidence of chronic periodontitis compared with a low FLI group were as follows: indeterminate FLI: 1.19 (1.12–1.26), high FLI: 1.32 (1.18–1.47). In the HSI and FSI scores, HR and 95% CIs for the incidence of chronic periodontitis were 1.13 (1.05–1.22) and 1.23 (1.05–1.31), respectively.ConclusionsAll NAFLD scores were associated with chronic periodontitis in the Korean population. As chronic periodontitis can aggravate the liver status, patients with NAFLD may need regular dental visits.

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Periodontitis and NAFLD‐related diseases: A bidirectional two‐sample Mendelian randomization study

Cited by 5 publications

References 58 publications

Association between periodontitis and NAFLD-related diseases: Results from the NHANES and Mendelian randomization study

Association between periodontitis and NAFLD-related diseases: Results from the NHANES and Mendelian randomization study

Updated mechanisms of MASLD pathogenesis

Association between nonalcoholic fatty liver disease scores and chronic periodontitis: A retrospective cohort study

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