Periodontitis and premature death: a 16‐year longitudinal study in a Swedish urban population

Söder, Birgitta; Li, Jin; Klinge, Björn; Söder, Per‐Östen

doi:10.1111/j.1600-0765.2006.00957.x

Cited by 68 publications

(66 citation statements)

References 41 publications

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“…Other studies were not considered since they assessed tooth loss solely as an exposure category of periodontal disease [60][61][62][63][64], treated the number of teeth as a score variable [65,66] or a confounding variable only [67] or no quantitative data have been given [68,69]. One study was excluded for evaluating only incident tooth loss [70].…”

Section: General Description Of Selected Studiesmentioning

confidence: 99%

The association of tooth loss with all-cause and circulatory mortality. Is there a benefit of replaced teeth? A systematic review and meta-analysis

et al. 2011

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We systematically reviewed whether the number of teeth is related to all-cause or circulatory mortality and whether replaced teeth are protective against all-cause or circulatory mortality. The search was based on the PubMed database. All cohort studies published in peer-reviewed journals were selected. Studies on periodontal disease and mortality were excluded if they did not provide information on the number of teeth. Risk estimates from studies with appropriate exposure definition, confounder adjustment and sample size were included in a meta-analysis. Three high-quality studies found a relationship between the number of teeth and circulatory mortality, whereas a moderate study did not. Two out of four moderate- to high-quality studies reported a relationship between the number of teeth and all-cause mortality. No study has investigated whether replaced teeth are protective against mortality. Therefore, denture use was taken as proxy. The methodological quality of studies on denture use and mortality was generally low to moderate. The findings of two moderate studies indicated an effect of prosthodontic replacements on all-cause mortality, which was supported in bias analysis. It is open whether competing risks of cause-specific death other than circulatory mortality reduce an effect of the number of teeth on all-cause mortality. An effect of denture use on circulatory mortality remains to be established, as well as whether the number of replaced teeth affects mortality. Specifying the role of potential pathways by which tooth loss-related mortality is mediated will possibly increase the value of dental treatment for general health.

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Section: General Description Of Selected Studiesmentioning

confidence: 99%

The association of tooth loss with all-cause and circulatory mortality. Is there a benefit of replaced teeth? A systematic review and meta-analysis

et al. 2011

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show abstract

“…The results of an epidemiological study 2001, from our group, showed that fairly young individuals with periodontal disease and missing molars are at increased risk of premature death caused by life threatening diseases such as malignant neoplasm, cardiovascular diseases, and diseases of the digestive system [25]. Recently, periodontal disease was also found to associate with head and neck cancer in patients who never smoked or consumed alcohol [26].…”

Section: Human Cytomegalovirus (Hcmv) Epstein-barr Virus (Ebv) and Hmentioning

confidence: 99%

Periodontal disease may associate with breast cancer

Söder

Yakob

Meurman

et al. 2010

Breast Cancer Res Treat

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“…The lack of association between AgP and telomere length is in agreement with the above-mentioned Japanese study [ 93 ], and suggests that such association may become evident only with the presence of disease over a longer period of time in adulthood. However, the association with chronic periodontitis suggests that exposure to chronic periodontal infl ammation and consequent oxidative stress may leave irreversible fi ngerprints in the form of reduced telomere length, which is in turn associated with higher mortality rates and shorter life-span, as observed in epidemiological studies in periodontitis cases [ 94 ].…”

Section: Dna Damage Caused By Oxidative Stressmentioning

confidence: 99%

Periodontitis and Oxidative Stress: Human Studies

Nibali

Henderson

Volti

et al. 2013

Studies on Periodontal Disease

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Periodontitis and premature death: a 16‐year longitudinal study in a Swedish urban population

Abstract: Young individuals with periodontitis and missing molars seem to be at increased risk for premature death by life-threatening diseases, such as neoplasms, and diseases of the circulatory and digestive systems.

Cited by 68 publications

References 41 publications

The association of tooth loss with all-cause and circulatory mortality. Is there a benefit of replaced teeth? A systematic review and meta-analysis

The association of tooth loss with all-cause and circulatory mortality. Is there a benefit of replaced teeth? A systematic review and meta-analysis

Periodontal disease may associate with breast cancer

Periodontitis and Oxidative Stress: Human Studies

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