Periodontitis and oral cancer - current concepts of the etiopathogenesis

Irani, Soussan; Barati, Iman; Badiei, Mohammadreza

doi:10.4081/oncol.2020.465

Cited by 49 publications

(55 citation statements)

References 162 publications

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“…NF-κB-dependent cytokines are molecular messengers highly involved in inflammation, angiogenesis, and proliferation [ 7 , 16 , 29 ], the altered expression of which have also been reported in non-malignant oral pathologies [ 15 , 29 ]. Abundant expression of cytokines and chemokines has been detected in the course of periodontitis [ 58 , 59 ]. To avoid any potential interference, our cohorts of volunteer donors had been pre-screened to eliminate those with any local acute or chronic inflammation (including periodontal disease) in the oral cavity upon direct clinical visual exploration.…”

Section: Discussionmentioning

confidence: 99%

Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma

Dikova

Jantus‐Lewintre

Bagán

2021

JCM

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This study aimed to investigate the role of a panel of salivary cytokines as biomarkers for early detection oral squamous cell carcinoma (OSCC), comparing their levels among healthy individuals, patients with oral leukoplakia (OL), and malignant lesions. Cytokine profiling analysis performed in a minimally invasive sample was correlated with clinicopathological variables in our patient cohorts. Unstimulated saliva was obtained from subjects with OSCC at early (n = 33) and advanced (n = 33) disease, OL with homogeneous (n = 33) and proliferative verrucous (n = 33) clinical presentations, and healthy controls (n = 25). Salivary IL-1α, IL-6, IL-8, IP-10, MCP-1, TNF-α, HCC-1, and PF-4 levels were analyzed by a sensitive bead-based multiplex immunoassay. Mean levels of IL-6, IL-8, TNF-α, HCC-1, MCP-1, and PF-4 differed significantly between OSCC, OL, and control saliva (p < 0.05). We found notably higher IL-6 and TNF-α in advanced compared to early OSCC stages. The area under the curve (AUC) for OSCC vs. control was greater than 0.8 for IL-6, IL-8, TNF-α, and HCC-1, and greater than 0.7 for PF-4. The presence of neck metastases (NM) was associated with increased IL-6 and TNF-α levels. Our findings suggest that salivary IL-6, IL-8, TNF-α, HCC-1, and PF-4 may discriminate between OSCC, OL, and healthy controls. IL-6 and TNF-α may indicate OSCC progression, being distinctive in the presence of NM.

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Section: Discussionmentioning

confidence: 99%

Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma

Dikova

Jantus‐Lewintre

Bagán

2021

JCM

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“…Oral squamous cell carcinoma (OSCC) is amongst the most preventable cancers and yet is the sixth most common malignancy globally. Risk factors for OSCC, apart from alcohol and tobacco use, include poor oral hygiene, chronic irritation caused by ill-fitting prosthesis or rough teeth surfaces, poor nutrition, and some chronic sepsis caused by fungi, bacteria, or viruses in the oral cavity [ 80 ].…”

Section: The Link Between Periodontal Diseases and Systemic Conditmentioning

confidence: 99%

“…For the early detection of oral cancer, salivary biomarkers and chemokines are the most promising tools. Patients with periodontal disease may be considered to have an increased risk for oral cancer [ 80 ]. Education and training of dentists can reduce the consequences of both periodontitis and oral cancer.…”

Section: The Link Between Periodontal Diseases and Systemic Conditmentioning

confidence: 99%

Periodontal Health and Systemic Conditions

et al. 2020

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According to the new classification proposed by the recent 2017 World Workshop on Periodontal and Peri-implant Diseases and Conditions, periodontitis, necrotizing periodontal diseases, periodontitis as a manifestation of systemic diseases, and systemic diseases or conditions affecting the periodontal supporting tissues, are considered as separate entities. Scientific evidence has demonstrated that periodontal diseases are not just simple bacterial infections but rather complex diseases of multifactorial complexity that interplay with the subgingival microbes, the host immune, and inflammatory responses. Despite dental plaque biofilm being considered the primary risk factor for periodontitis in the vast majority of patients that dentists encounter on a daily basis, there are other factors that can also contribute and/or accelerate pathologic progressive attachment loss. In this article, the authors aim to briefly review and discuss the present evidence regarding the association between periodontal diseases and systemic diseases and conditions.

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“…Tobacco and alcohol seem to be the major risk factors for OSCC, but recent evidence also shows an association of other factors, such as inflammation and oral microbiome, in oral cancer. There seem to be several inflammatory mediators, salivary proteins, and oral microbiota that are common between inflammatory diseases of the oral cavity, such as periodontitis and oral cancer [ 2 , 3 , 4 ]. Despite some advances in diagnosis and treatment, the 5-year survival rate for OSCC is less than 50% across all stages, and has not greatly improved for the past few decades [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Cell Culture Models to Investigate Oral Carcinogenesis: A Scoping Review

Suryaprakash

Kujan

Shearston

et al. 2020

IJMS

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Three-dimensional (3-D) cell culture models, such as spheroids, organoids, and organotypic cultures, are more physiologically representative of the human tumor microenvironment (TME) than traditional two-dimensional (2-D) cell culture models. They have been used as in vitro models to investigate various aspects of oral cancer but, to date, have not be widely used in investigations of the process of oral carcinogenesis. The aim of this scoping review was to evaluate the use of 3-D cell cultures in oral squamous cell carcinoma (OSCC) research, with a particular emphasis on oral carcinogenesis studies. Databases (PubMed, Scopus, and Web of Science) were systematically searched to identify research applying 3-D cell culture techniques to cells from normal, dysplastic, and malignant oral mucosae. A total of 119 studies were included for qualitative analysis including 53 studies utilizing spheroids, 62 utilizing organotypic cultures, and 4 using organoids. We found that 3-D oral carcinogenesis studies had been limited to just two organotypic culture models and that to date, spheroids and organoids had not been utilized for this purpose. Spheroid culture was most frequently used as a tumorosphere forming assay and the organoids cultured from human OSCCs most often used in drug sensitivity testing. These results indicate that there are significant opportunities to utilize 3-D cell culture to explore the development of oral cancer, particularly as the physiological relevance of these models continues to improve.

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Periodontitis and oral cancer - current concepts of the etiopathogenesis

Cited by 49 publications

References 162 publications

Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma

Potential Non-Invasive Biomarkers for Early Diagnosis of Oral Squamous Cell Carcinoma

Periodontal Health and Systemic Conditions

Three-Dimensional Cell Culture Models to Investigate Oral Carcinogenesis: A Scoping Review

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