Periodontitis and inflammatory bowel disease: a meta-analysis

Abstract

Background: Periodontitis was reported to be associated with inflammatory bowel disease (IBD). However, the association between them has not been firmly established in the existing literature. Therefore, this meta-analysis was conducted to evaluate the relationship between periodontitis and IBD. Methods: Electronic databases were searched for publications up to August 1, 2019 to include all eligible studies. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated to determine the association between periodontal disease and IBD using a random or fixed effects model according to heterogeneity. Results: Six eligible studies involving 599 IBD patients and 448 controls were included. The pooled OR between periodontitis and IBD was 3.17 (95% CI: 2.09-4.8) with no heterogeneity observed (I 2 = 0.00%). The pooled ORs were 3.64 (95% CI: 2.33-5.67) and 5.37 (95% CI: 3.30-8.74) for the associations between periodontitis and the two subcategories of IBD, Crohn' s disease and ulcerative colitis, respectively. Conclusions: The results demonstrated that periodontitis was significantly associated with IBD. However, the mechanisms underlying periodontitis and IBD development are undetermined. Further studies are needed to elucidate this relationship.

Oral health and salivary function in ulcerative colitis patients

“…CD is considered to be a Th1 disease whereas UC has more characteristics of a Th2-type disease. 31 As mentioned in the introduction, the aetiology of UC is considered to be a combination of genetic predisposition, environmental factors and a dysbiotic microbiota with an excessive host response. Proteobacteria are one of the most common phyla in the human gut microbiota and are found at different body sites, such as skin, tongue, vaginal tract and in the oral cavity.…”

“…The difference in oral health might be related to differences in immunological responses in both diseases. CD is considered to be a Th1 disease whereas UC has more characteristics of a Th2‐type disease 31 …”

Biosensor and Lab-on-a-chip Biomarker-identifying Technologies for Oral and Periodontal Diseases

“…Since periodontitis is a chronic inflammatory disease associated with microbial dysbiosis and host-driven tissue destruction (Atieh et al, 2014;Artese et al, 2015;Garde et al, 2019;Baeza et al, 2020) (Darre et al, 2008Engebretson and Kocher, 2013;Faggion Jr. et al, 2016;Ziukaite et al, 2018;Jain et al, 2019) Cardiovascular disease (Mustapha et al, 2007;Paraskevas et al, 2008;Freitas et al, 2012;Teeuw et al, 2014;Munz et al, 2018;Roca-Millan et al, 2018;Joshi et al, 2019;Munoz Aguilera et al, 2020) ( Bahekar et al, 2007;Blaizot et al, 2009;Almeida et al, 2018) Rheumatoid arthritis (Han and Reynolds, 2012;Kaur et al, 2014;Bender et al, 2017;Calderaro et al, 2017;Eskandari-Nasab et al, 2017;Hussain et al, 2020) ( Tang et al, 2017;Qiao et al, 2020) Obesity (Akram et al, 2016) (Papageorgiou et al, 2015) Irritable bowel disease * (Eskandari-Nasab et al, 2017;Papageorgiou et al, 2017;Lauritano et al, 2019;She et al, 2020) Osteoporosis (Kornman, 2008;Darveau, 2010), it is recognized that a single oral pathogen would not be sufficient to induce the most common forms of periodontitis. However, historically there were several studies focused on small subgroups of patients with rapidly progressing bone destruction occurring around certain teeth (molars and incisors), called localized aggressive periodontitis, whi...…”

Generalized Gingival Hyperplasia and Rectorrhagia in a 13-Year-Old Boy

“…2 Patients with CD are at increased risk of having impaired oral health and particularly periodontitis (odds ratio, 3.64; 95% confidence interval, 2.33-5.67) compared with patients without CD. 3 This susceptibility can be explained by the similarities in the pathogenicity between periodontitis and CD, particularly related to the inflammatory pathways and dysbiotic mechanisms in the microbial environment. This case report highlights the key role of dentists in the screening and diagnosis of systemic diseases that might present with oral manifestations, and the necessity of a close collaboration between oral health specialists and physicians.…”