Periodontitis and Gingivitis in Inflammatory Bowel Disease

Vavricka, Stephan R.; Manser, Christine N.; Hediger, Sebastian; Vögelin, Marius; Scharl, Michael; Biedermann, Luc; Rogler, Sebastian; Seibold, Frank; Sanderink, René B. A.; Attin, Thomas; Schoepfer, Alain; Fried, Michael; Rogler, Gerhard; Frei, Pascal

doi:10.1097/01.mib.0000438356.84263.3b

Cited by 108 publications

(130 citation statements)

References 26 publications

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“…Poor dental health can adversely affect a number of systemic conditions and diseases, such as cardiovascular diseases (4), diabetes (5), respiratory diseases (6), and inflammatory bowel diseases (7), and can even lead to preterm delivery (8,9) and systemic disease (10)(11)(12). However, the associations between periodontal disease and sperm abnormalities have not been adequately investigated.…”

Section: Introductionmentioning

confidence: 99%

Association between periodontal status and idiopathic male infertility

et al. 2016

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About 30% of male infertility cases are idiopathic. Previous studies reported a positive correlation between deep periodontal pockets and sperm sub-motility, which suggests that periodontitis might have a role in idiopathic semen abnormality pathospermia. We evaluated correlations between periodontal infection parameters and the results of sperm analysis of men with idiopathic infertility. In this observational study, semen quality and periodontal status were analyzed for 95 otherwise healthy men attending an andrology unit for sperm analysis. Half the men in the sperm pathology and normozoospermia groups (50.8% and 50%, respectively) had poor periodontal status. Among the 95 participants, 38% had oligozoospermia, 28% had asthenozoospermia, 16% had cryptozoospermia, and 15% were classified as normozoospermic. Sperm pathology category was not associated with frequency of deep periodontal pockets or calculus. Bleeding on probing was significantly lower among men with asthenozoospermia than among those with normozoospermia. Poor periodontal status was not associated with any sperm pathology category or parameter. In contrast with previous findings, the present results indicate that pathospermia and poor semen quality are not associated with periodontal infection in men with idiopathic infertility. (J Oral Sci 58, 247-253, 2016)

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Section: Introductionmentioning

confidence: 99%

Association between periodontal status and idiopathic male infertility

et al. 2016

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“…Periodontitis is related to rheumatoid arthritis, and treatment for the former has an effect on both the latter and systemic inflammation (Payne et al, 2015). In addition, preeclampsia (Ha et al, 2014), other complications during pregnancy (Zi et al, 2015), and inflammatory bowel disease (Vavricka et al, 2013), amongst other conditions, have been shown to be associated with chronic periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Assessment of CASP gene polymorphisms in periodontal disease

Sw¹,

Kim²,

Chung³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Caspases (CASP) are intracellular proteases that play roles as mediators of apoptosis. Activation of caspase 3 is enhanced in chronic periodontitis. Thus, we hypothesized that single nucleotide polymorphisms (SNPs) of CASP genes might be associated with this condition in the Korean population. To investigate whether such polymorphisms might be involved in the development of periodontal disease, 51 patients and 33 control subjects were assessed. A total of 201 CASP gene SNPs were analyzed with genotypes being determined using and Axiom™ genomewide human assay. SNPStats and SPSS 18.0 were used for the analysis of genetic data and logistic regression models were utilized to evaluate odds ratios, 95% confidence intervals, and P values. Of the 201 SNPs, only three (rs12108497, rs4647602, and rs113420705, all in the CASP3 gene) were significantly associated with chronic periodontitis (P < 0.05). The minor allele frequencies of these SNPs were higher in the patient group than in the control group. In addition, the TC and GT haplotypes 18070 S.W. Kang et al. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 18069-18077 (2015) formed by rs4647602 and rs113420705 were found to be associated with chronic this disease (TC haplotype, P = 0.0039; GT haplotype, P = 0.002). These results suggest that CASP3 gene polymorphisms may be associated with susceptibility to periodontal disease in the Korean population.

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“…However, since then further prospective trials have identified that IBD patients have higher provenances of periodontal disease, deeper pocket depth and more clinical attachment loss. 55,56 Malnutrition Malnutrition is very prevalent within the IBD population. Literature has previously estimated this number to be almost one in four outpatients, and almost nine out of ten inpatients.…”

Section: Periodontal Diseasementioning

confidence: 99%

Inflammatory bowel disease and oral health

Chandan

Thomas

2017

BDJ Team

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Risk factors involved in IBDIBD is thought to result from inappropriate and ongoing activation of the mucosal immune system facilitated by defects in both the intestinal epithelium and mucosal immune system. 5 There are both genetic and environmental factors implicated in the aetiology of IBD. 6 Although traditionally associated with the developed world, recent epidemiological studies suggest an increasing incidence in rapidly developing countries, especially in South-East Asia. 7 In addition, the increased risk of IBD in the immigrant populations in the West suggests environment has a role in the development of IBD. 8 Genetic Detailed genetic mapping has identified specific genetic changes on chromosome 16 carried in families which appear linked to CD, however no significant changes have been mapped as of yet to UC. 9,10 Specifically, variants of the NOD2 gene provide the strongest association with susceptibility to CD. NOD2 plays a key role in regulating the gut mucosal barrier involving, specifically, the microbiota, as well as the related response by the innate and adaptive immune system. The IBDchip European Project showed NOD2 has been implicated in ileal location colitis with stenosing and penetrating disease behaviour. 11 A genome wide association study has also identified a strong link between the IL23R gene and CD. 12 The gene in particular codes for interleukin 23 that plays a role in regulating innate immunity within the intestine. 13 Cigarette smoking Unusually, cigarette smoking is associated with decreased rates of incidence of UC and has been associated with protective features to prevent further flare-ups of the condition 14-19 such as relapses, 20 ©SEBASTIAN KAULITZKI/Science Photo Library/Getty J. S. Chandan 1 and T. Thomas 1 summarise the treatments for inflammatory bowel disease (IBD) and how anti-inflammatory medications can have side effects that affect the oral cavity.

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Periodontitis and Gingivitis in Inflammatory Bowel Disease

Abstract: IBD, and especially perianal disease in CD, is associated with periodontitis. Optimal therapeutic strategies should probably focus on treating both local oral and systemic inflammation.

Cited by 108 publications

References 26 publications

Association between periodontal status and idiopathic male infertility

Association between periodontal status and idiopathic male infertility

Assessment of CASP gene polymorphisms in periodontal disease

Inflammatory bowel disease and oral health

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