Periodontitis and Gestational Diabetes Mellitus in Non‐Smoking Females

Chokwiriyachit, Anyarat; Dasanayake, Ananda P.; Suwannarong, Waraporn; Hormdee, Daranee; Sumanonta, Gunniga; Prasertchareonsuk, Witoon; Wara-aswapati, Nawarat; Combellick, Joan; Pitiphat, Waranuch

doi:10.1902/jop.2012.120344

Cited by 48 publications

(70 citation statements)

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“…1). Ten studies [19, 24, 26, 27, 42–47]. that met the eligibility criteria were included in the analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Studies that were excluded were either conducted in diabetic populations other than GDM or lacked relevant information for calculation of risk estimates. Studies were conducted in the USA, [24, 26, 46]; Brazil, [27, 47]; Spain, [43]; Thailand, [19]; Saudi Arabia, [44]; Turkey, [42] and India [45]. There were six case–control studies [19, 26, 27, 42, 45, 47], three cross sectional studies [43, 44, 46] and one cohort study [24].…”

Section: Resultsmentioning

confidence: 99%

“…Definitions used for periodontitis varied widely across studies (Table 1). Seven studies assessed GDM as two or more abnormal values of oral glucose tolerance test (OGTT) [19, 24, 27, 42–44, 47] based on either the O’Sullivan’s [34] or Carpenter and Coustan’s [32] criteria (Table 1). One study [27] defined GDM based on at least one abnormal value of the OGTT [48] and another defined GDM as a positive glucose challenge test [45].…”

Section: Resultsmentioning

confidence: 99%

“…Prior research has linked periodontitis with risk of adverse health outcomes including diabetes [17]. It is thought that bacteria and bacterial products such as lipopolysaccharide from the sub gingival plaque result in the release of pro-inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, interleukin-8, and C-reactive protein) from the inflamed periodontal tissue [18], which enter circulation and interfere with insulin signaling and causing insulin antagonism and pancreatic β-cell destruction [19, 20]. The sustained elevation of these cytokines is believed to interfere with carbohydrate metabolism and glucose tolerance [19].…”

Section: Introductionmentioning

confidence: 99%

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Periodontitis and gestational diabetes mellitus: a systematic review and meta-analysis of observational studies

Abariga

Whitcomb

2016

BMC Pregnancy Childbirth

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BackgroundGestational diabetes mellitus (GDM) is glucose intolerance with first onset during pregnancy and is associated with serious maternal and fetal complications. The etiology of GDM is not well understood, but systemic inflammation effects on insulin signaling and glucose metabolism is suspected. Periodontal disease is a chronic inflammatory condition that induces local and host immune responses and has been evaluated for a potential role in development of GDM. Results from studies evaluating the association between periodontitis and GDM are mixed. We performed a systematic review and meta-analysis to summarize available data regarding the association between periodontitis and GDM.MethodsTwelve electronic databases were searched for observational studies of the association between periodontitis and GDM through March 2016. Eligible studies were assessed for quality and heterogeneity. Random effects models were used to estimate summary measures of association.ResultsWe identified 44 articles from 115 potentially relevant reports of which 10 studies met our eligibility criteria. Clinical diagnostic criteria for periodontitis and GDM varied widely among studies, and moderate heterogeneity was observed. Random effects meta-analysis of all included studies with a total of 5724 participants including 624 cases, showed that periodontitis is associated with an increased risk of GDM by 66 %, (OR = 1.66, 95 % CI: 1.17 to 2.36; p < 0.05), I2 = 50.5 %. Similar results were seen in sub-analysis restricted to data from methodologically high quality case–control studies including 1176 participants including 380 cases, (OR = 1.85, 95 % CI: 1.03 to 3.32); p < 0.05), I2 = 68.4 %. Meta-analysis of studies that adjusted for potential confounders estimated more than 2-fold increased odds of GDM among women with periodontitis (aOR = 2.08, 95 % CI: 1.21 to 3.58, p = 0.009, I2 = 36.9 %).ConclusionMeta-analysis suggests that periodontitis is associated with a statistically significant increased risk for GDM compared to women without periodontitis. Robust prospective study designs and uniform definition for periodontitis and GDM definitions are urgently needed to substantiate these findings.

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“…1). Ten studies [19, 24, 26, 27, 42–47]. that met the eligibility criteria were included in the analysis.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Periodontitis and gestational diabetes mellitus: a systematic review and meta-analysis of observational studies

Abariga

Whitcomb

2016

BMC Pregnancy Childbirth

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“…Essa condição também torna a gestante vulnerável a outros acometimentos, como diabetes mellitus gestacional (20) . Ainda, a doença periodontal tem sido relacionada como fator de risco para o parto prematuro e baixo peso ao nascer (21) .…”

Section: Discussionunclassified

Programa Rede Mãe Paranaense: Análise Da Atenção Pré-Natal Em Uma Regional De Saúde

Baggio¹,

Pereira²,

Guimarães³

et al. 2016

Cogitare Enferm.

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RESUMO: Estudo quantitativo, descritivo, retrospectivo, que objetivou analisar a atenção pré-natal em uma Regional de Saúde do Estado do Paraná, entre 2012 e 2013. Os dados foram coletados de relatórios mensais e anuais, com instrumento contendo indicadores de avaliação conforme matrizes do Programa Rede Mãe Paranaense. De acordo com o preconizado pelo Programa, os municípios da Regional de Saúde estudada obtiveram resultados insatisfatórios no que diz respeito ao início do pré-natal no primeiro trimestre e realização de testes rápidos de HIV e sífilis, visto que em sua totalidade foram inferiores a 70%. Quanto aos registros e informações referentes à realização do pré-natal, identificou-se ausência de informações sobre a quantidade de gestantes imunizadas e que realizaram consultas odontológicas, e possível atraso de registro nos sistemas de informação. Considerando-se a implantação do Programa Rede Mãe Paranaense em 2012, sugere-se a realização de outros estudos para avaliar as ações de saúde no pré-natal e seus registros. PROGRAMA REDE MÃE PARANAENSE: ANÁLISIS DE LA ATENCIÓN PRENATAL EN UNA REGIONAL DE SALUD RESUMEN: Estudio cuantitativo, descriptivo, retrospectivo con objeto de analizar la atención prenatal en una Regional de Salud del Estado de Paraná entre 2012 y 2013. Los datos fueron recolectados de relatos mensuales y anuales, mediante instrumento con indicadores de evaluación según matrices del Programa Rede Mãe Paranaense (Red de Madres del Estado de Paraná). Según la recomendación del Programa, los municipios de la Regional de Salud estudiada alcanzaron resultados insatisfactorios respecto al inicio del prenatal en el primer trimestre y aplicación de pruebas rápidas de VIH y sífilis, ya que en su totalidad fueron inferiores al 70%. Respecto a los registros e informaciones referentes a la práctica del prenatal, fue identificada ausencia de informaciones sobre la cuantidad de gestantes inmunizadas y que hicieron consultas odontológicas, y posible retraso de registro en los sistemas de información. Ante la implantación del Programa Rede Mãe Paranaense en 2012, se sugiere el desarrollo de otros estudios para evaluar las acciones de salude en el prenatal y sus registros. DESCRIPTORES: Cuidado prenatal; Mortalidad materna; Atención primaria de salud; Programas de salud; Equipos de salud.

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Periodontal disease as a complication of diabetes mellitus

Taylor¹,

Graves²,

Lamster³

2014

Diabetes Mellitus and Oral Health

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Periodontitis and Gestational Diabetes Mellitus in Non‐Smoking Females

Abstract: The results suggest that periodontitis is associated with GDM. Therefore, clinicians should assess periodontal conditions of pregnant females.

Cited by 48 publications

References 31 publications

Periodontitis and gestational diabetes mellitus: a systematic review and meta-analysis of observational studies

Periodontitis and gestational diabetes mellitus: a systematic review and meta-analysis of observational studies

Programa Rede Mãe Paranaense: Análise Da Atenção Pré-Natal Em Uma Regional De Saúde

Periodontal disease as a complication of diabetes mellitus

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