Periodontally accelerated osteogenic orthodontics: An interdisciplinary approach for faster orthodontic therapy

Adusumilli, Srikanth; Yalamanchi, Lohith; Yalamanchili, Pallavi Samatha

doi:10.4103/0975-7406.137244

Cited by 7 publications

(7 citation statements)

References 19 publications

(19 reference statements)

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“…Orthodontic tooth movement is achieved via the impact of mechanical force on periodontal tissue, which is a remodeling process accompanying bone regeneration in tension areas and bone resorption in pressure areas ( 1 , 2 ). In bone remodeling, the remodeling of alveolar bone is most important.…”

Section: Introductionmentioning

confidence: 99%

Expression and regulation of the ERK1/2 and p38 MAPK signaling pathways in periodontal tissue remodeling of orthodontic tooth movement

Jiang

Tang

2017

Mol Med Report

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The present study aimed to investigate the expression and regulation of extracellular signal-regulated kinase (ERK)1/2 and p38 mitogen-activated protein kinase (MAPK) signaling pathways in periodontal tissue remodeling of orthodontic tooth movement. Sprague Dawley rats with orthodontic tooth movement were generated. After tension stress for 1, 3, 5, 7 and 14 days, the protein and mRNA expression levels of ERK1/2 and p38 in periodontal tissue were determined by western blotting and reverse transcription-quantitative polymerase chain reaction (RT-qPCR), respectively. Primary human periodontal ligament cells (hPDLCs) were separated and characterized. Following exposure to centrifugal force for 1, 2, 6, 8 and 12 h, the protein expression levels of ERK1/2 and p38 MAPK, and the mRNA expression levels of ERK1/2, p38 and osteogenesis associated-genes [including alkaline phosphatase (ALP), osteopontin (OPN), collagen I (Col I), osteocalcin (OCN) and bone sialoprotein (BSP)] were measured. The protein expression levels of ERK1/2 and p38 MAPK in periodontal tissue and hPDLCs treated with stress were similar to those in the control groups. However, compared with the control, the phosphorylation and mRNA expression levels of the genes encoding ERK1/2 and p38 MAPK in orthodontic periodontal tissue and forced hPDLCs were elevated. These increases reached a peak at 5 days for orthodontic periodontal tissue and at 6 h for forced hPDLCs. In forced hPDLCs, the mRNA expression levels of ALP, OPN, Col I, OCN and BSP were notably and continuously upregulated in a time-dependent manner. In addition, hPDLCs were treated with the ERK1/2 inhibitor, PD098059, and the p38 MAPK inhibitor, SB203580, and the mRNA expression levels of the osteogenesis associated-genes were then measured using RT-qPCR. Following treatment with the ERK1/2 inhibitor and p38 MAPK inhibitor, the mRNA expression levels of ALP, OPN, Col I, OCN and BSP were significantly downregulated. In conclusion, ERK1/2 and p38 MAPK signaling pathways may be positively and closely associated with periodontal tissue remodeling of orthodontic tooth movement.

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Section: Introductionmentioning

confidence: 99%

Expression and regulation of the ERK1/2 and p38 MAPK signaling pathways in periodontal tissue remodeling of orthodontic tooth movement

Jiang

Tang

2017

Mol Med Report

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“…PAOO has shown to have reduced treatment time, produce lower cortical bone resistance leading to reduced root resorption, enhancement of post-orthodontic stability, increased bone support since there is supplementation of the bone graft. However, PAOO still has risks since it is an invasive procedure and is expensive [20][21][22][23][24].…”

Section: Surgical Methodsmentioning

confidence: 99%

Accelerated Orthodontics

Patil¹,

Maan²

2019

Current Approaches in Orthodontics

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Clinical orthodontics is ever dynamic branch of Dentistry. Traditionally orthodontics was always considered as aesthetic treatment of face & also needed for proper oral oral function. This treatment may take up 2-3 years of total duration. The chapter describes changing trends in this aspect wherein we speed up the treatment by various methods thus reducing the overall time duration. These modalities include alteration in bio mechanics, pharmacological, chemical & by biological means. It is also cautioned here that the clinician has to take up these changing trends based on sound clinical knowledge & evidence based applicability.

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“…Unlike osteotomies, which involve the complete thickness of the bone, corticotomy surgery is specifically directed at the cortical bone, leaving the medullary bone untouched [5]. A comprehensive overview of the indications, and contraindications, as well as the advantages and disadvantages associated with this procedure can be found in Table 3 [5, [14][15][16].…”

Section: Corticotomymentioning

confidence: 99%

“…Precise corticotomy cuts are meticulously placed while ensuring continuous irrigation, which is achieved using specialized tools such as a Piezosurgical device or a micromotor. In cases where it is deemed necessary, graft material may be introduced into the corticotomy sites to enhance bone thickness and support structural integrity [14]. What makes corticotomies particularly intriguing is their impact on orthodontic movements, which can be rendered more efficient due to the trabecular bone structure's response to the biological stimulation induced by corticotomies [15].…”

Section: Table 3: Various Indications Contraindications Advantages An...mentioning

confidence: 99%

Accelerated Orthodontics: Stepping Into the Future Orthodontics

Gabada,

Reche,

Saoji

et al. 2023

Cureus

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Orthodontic treatment signifies a transformative journey for individuals seeking not only enhanced oral health but also a boost in aesthetics and self-confidence. Nonetheless, the protracted timeline associated with conventional orthodontic care has been a persistent concern for both patients and practitioners. In this comprehensive review, we embark on an exploration of innovative strategies aimed at expediting orthodontic tooth movement (OTM). By doing so, we aspire to curtail treatment duration and mitigate potential risks, ultimately culminating in an elevated and more fulfilling patient experience.Traditionally, orthodontists heavily leaned on surgical techniques to hasten tooth movement. However, the recent landscape of orthodontics has been profoundly shaped by technological advancements and groundbreaking research findings, ushering in an era characterized by the embrace of minimally invasive approaches. These progressive methodologies encompass procedures like Piezocision, Discision, and Microosteoperforation (Alveocentesis). Beyond the obvious benefits of reduced patient discomfort, these techniques significantly truncate treatment periods, a development that addresses a primary concern of many patients. Moreover, this review delves into non-invasive alternatives, including cyclic vibrations, photobiomodulation, direct light electric current, and static or pulsed magnetic fields, as well as systemic and local administration of biological substances and hormones, all of which hold substantial promise in optimizing OTM. Furthermore, our exploration extends to a diverse spectrum of medications that have demonstrated their efficacy in expediting OTM. These encompass NSAIDs, acetaminophen, corticosteroids, bisphosphonates, herbal medicine biomaterials, and synthetic biomaterials like graphene dioxide. Every technique and medication is subjected to meticulous evaluation, taking into account its indications, contraindications, advantages, disadvantages, clinical implications, and limitations. Through this review, we endeavor to equip orthodontic professionals with a profound understanding of these innovative strategies. By doing so, we enable them to make informed decisions, tailored meticulously to meet the unique needs of each patient. In an ever-evolving field like orthodontics, staying abreast of these advancements becomes paramount, ultimately contributing to heightened treatment efficacy and enhanced patient satisfaction. The adoption of these innovative strategies not only holds the potential for improved clinical outcomes but also champions a patient-centric approach that could fundamentally reshape the landscape of orthodontic care.

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Periodontally accelerated osteogenic orthodontics: An interdisciplinary approach for faster orthodontic therapy

Cited by 7 publications

References 19 publications

Expression and regulation of the ERK1/2 and p38 MAPK signaling pathways in periodontal tissue remodeling of orthodontic tooth movement

Expression and regulation of the ERK1/2 and p38 MAPK signaling pathways in periodontal tissue remodeling of orthodontic tooth movement

Accelerated Orthodontics

Accelerated Orthodontics: Stepping Into the Future Orthodontics

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