Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor‐5 (rhGDF‐5) in an absorbable collagen sponge carrier into one‐wall intrabony defects in dogs: a dose‐range study

Kim, Tae Kyun; Wikesjö, Ulf M.E.; Cho, Kyoo-Sung; Chai, Jung‐Kiu; Pippig, Susanne; Siedler, Michael; Kim, Chong Kwan

doi:10.1111/j.1600-051x.2009.01420.x

Cited by 58 publications

(66 citation statements)

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“…Application of rhGDF-5/β-TCP however, resulted in greater, although statistically not significant, probing depth reduction and clinical attachment gain compared to the control. These findings are in agreement with those reported in previous preclinical studies indicating a beneficial effect of GDF-5 on periodontal wound healing/regeneration [10,11,19]. On the other hand, the magnitude of clinical improvements appeared to be in the range of those obtained with other regenerative materials such as a recombinant plateletderived growth factor (rhPDGF BB) on a β-TCP carrier, an enamel matrix protein derivative alone or guided tissue regeneration either alone or combined with grafting materials [20][21][22][23][24][25][26][27].…”

Section: Discussionsupporting

confidence: 93%

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A phase IIa randomized controlled pilot study evaluating the safety and clinical outcomes following the use of rhGDF-5/β-TCP in regenerative periodontal therapy

et al. 2011

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To present the safety profile, the early healing phase and the clinical outcomes at 24 weeks following treatment of human intrabony defects with open flap debridement (OFD) alone or with OFD and rhGDF-5 adsorbed onto a particulate β-tricalcium phosphate (β-TCP) carrier. Twenty chronic periodontitis patients, each with at least one tooth exhibiting a probing depth ≥6 mm and an associated intrabony defect ≥4 mm entered the study. Ten subjects (one defect/patient) were randomized to receive OFD alone (control) and ten subjects OFD combined with rhGDF-5/β-TCP. Blood samples were collected at screening, and at weeks 2 and 24 to evaluate routine hematology and clinical chemistry, rhGDF-5 plasma levels, and antirhGDF-5 antibody formation. Plaque and gingival indices, bleeding on probing, probing depth, clinical attachment level, and radiographs were recorded pre-and 24 weeks postsurgery. Comparable safety profiles were found in the two treatment groups. Neither antirhGDF-5 antibody formation nor relevant rhGDF-5 plasma levels were detected in any patient. At 6 months, treatment with OFD+rhGDF-5/β-TCP resulted in higher but statistically not significant PD reduction (3.7±1.2 vs. 3.1±1.8 mm; p=0.26) and CAL gain (3.2±1.7 vs. 1.7± 2.2 mm; p=0.14) compared to OFD alone. In the tested concentration, the use of rhGDF-5/β-TCP appeared to be safe and the material possesses a sound biological rationale. Thus, further adequately powered, randomized controlled clinical trials are warranted to confirm the clinical relevance of this new approach in regenerative periodontal therapy. rhGDF-5/β-TCP may represent a promising new techology in regenerative periodontal therapy.

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Section: Discussionsupporting

confidence: 93%

“…Moreover, rhGDF-5 may provide an environment conducive to periodontal wound healing/regeneration affecting extracellular matrix metabolism [8]. Still other studies have shown significant periodontal regeneration in discriminating large animal models following surgical implantation of both GDF-5 and GDF-7 [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

A phase IIa randomized controlled pilot study evaluating the safety and clinical outcomes following the use of rhGDF-5/β-TCP in regenerative periodontal therapy

et al. 2011

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“…The histologic sections were photographed and digitized with a light microscope ♪ (Olympus BX50, Optical Co. LTD, Japan) coupled to a digital camera ♪♪ (C5060WZ, Sony Electronic Inc., Tokyo, Japan), at a lens magnification of ×25 that's connected to a monitor and a personal computer, using the crest of the alveolar bone and the root notch as reference points [13] (Figure 2). The histometric parameters were: -Linear measurements were performed after verification of anatomical landmarks at high magnification, and by outlining the borders of the various structures with a mouse cursor.…”

Section: For Histometric Analysismentioning

confidence: 99%

Histological and Histomorphometric Study of the Effect of Strontium Ranelate on the Healing of One-Wall Intrabony Periodontal Defects in Dogs

Elgendy¹

2013

J Cytol Histol

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Background: Periodontal regeneration aims at the restitution of supporting periodontal tissues lost due to periodontal diseases. With an aim of improving bone regeneration, strontium ranelate and related compounds were developed and have become increasingly popular in osteoporosis treatment. The aim of the present study was to evaluate the effect of the strontium ranelate 2% gel on the regeneration of the surgically created intrabony defect in dogs.

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“…Finn et al [20] Évaluation Concernant les 7 études précliniques, il y avait six modèles canins [22,25,[32][33][34][35] et un modèle chez le primate [36]. Six études concernaient l'utilisation d'éponges de collagène implantées seules ou en association avec des facteurs de croissance dans la régénération de défauts osseux créés chirurgicalement [25,[32][33][34][35][36]. Dans trois études, la régénération alvéolaire était évaluée en fonction de différentes concentrations de rhBMP-2 [34], de BMP6 [33], ou de rhGDF5 [32], avec une éponge de collagène comme vecteur.…”

Section: Utilisation Des éPonges De Collagène Pour La Régénération Osunclassified

“…Six études concernaient l'utilisation d'éponges de collagène implantées seules ou en association avec des facteurs de croissance dans la régénération de défauts osseux créés chirurgicalement [25,[32][33][34][35][36]. Dans trois études, la régénération alvéolaire était évaluée en fonction de différentes concentrations de rhBMP-2 [34], de BMP6 [33], ou de rhGDF5 [32], avec une éponge de collagène comme vecteur. Dans chacune de ces trois études, l'éponge de collagène seule servait de contrôle.…”

Section: Utilisation Des éPonges De Collagène Pour La Régénération Osunclassified

Intérêt des éponges de collagène pour prévenir la résorption osseuse alvéolaire post-extractionnelle : revue systématique de la littérature

Blanchy

Babilotte

Fénelon

et al. 2016

Med Buccale Chir Buccale

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Résumé -Introduction :La cicatrisation alvéolaire post-extractionnelle est accompagnée systématiquement d'une résorption osseuse plus ou moins importante selon les sites anatomiques et la pathologie initiale. Cette résorption osseuse peut parfois compromettre la mise en place d'implants dentaires. L'objectif de cette revue systématique de la littérature était d'évaluer si les éponges de collagène permettaient de limiter cette résorption osseuse. Matériels et méthodes : Les bases de données Medline et Pubmed ont été consultées pour la période 1986-2015. Résultats : Les études comparant les éponges de collagène à une cicatrisation naturelle n'ont pas montré de différence significative en ce qui concerne la cicatrisation alvéolaire. En revanche, les études comparant l'implantation d'une éponge de collagène comme vecteur de facteurs de croissance à une éponge de collagène seule montraient un effet positif des facteurs de croissance pour corriger un défaut osseux parodontal ou pour limiter la résorption post-extractionnelle. Discussion : Il n'y a pas d'intérêt à placer une éponge de collagène seule dans une alvéole d'extraction pour limiter la résorption osseuse. En revanche, la mise en place dans l'alvéole d'une éponge de collagène associée à des facteurs de croissance permet de maintenir la hauteur et la largeur de la crête alvéolaire. Conclusion : Les éponges de collagène doivent être utilisées uniquement comme des hémostatiques locaux après une extraction dentaire. Rien n'indique dans la littérature que ces éponges pourraient avoir un rôle dans le maintien du volume osseux alvéolaire.Abstract -Use of acellular collagen sponges to prevent post-extraction alveolar bone resorption: systematic review of the literature. Introduction: Alveolar bone healing following dental extraction is usually accompanied by a resorption of alveolar bone. This resorption of alveolar bone may hinder the insertion of dental implants. The aim of this literature review was to evaluate whether acellular collagen sponge (ACS) grafting could limit alveolar bone resorption and maintain alveolar bone volume after dental extraction. Materials and Methods: The Medline and Pubmed databases were searched for the period 1986-2015. Results: Studies comparing ACS grafting with natural healing did not show any significant differences concerning alveolar bone healing and bone volume preservation. Experiments comparing the implantation of ACS alone versus ACS loaded with growth factors such as rh-BMP2 showed better results using rh-BMP2 for guided periodontal regeneration and post-extraction alveolar bone volume preservation. Discussion: This systematic review of the literature shows that there is no evidence that grafting a collagen sponge inside an alveolar socket would limit alveolar bone resorption. On the other hand, the insertion of a collagen sponge loaded with growth factors (such as rhBMP2) allows maintaining the height and width of the alveolar ridge. Conclusion: Acellular collagen sponges must be used as a local haemostatic agent. They have n...

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Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor‐5 (rhGDF‐5) in an absorbable collagen sponge carrier into one‐wall intrabony defects in dogs: a dose‐range study

Abstract: Surgical implantation of rhGDF-5/ACS may be used safely to support periodontal wound healing/regeneration in intrabony periodontal defects without complications.

Cited by 58 publications

References 54 publications

A phase IIa randomized controlled pilot study evaluating the safety and clinical outcomes following the use of rhGDF-5/β-TCP in regenerative periodontal therapy

A phase IIa randomized controlled pilot study evaluating the safety and clinical outcomes following the use of rhGDF-5/β-TCP in regenerative periodontal therapy

Histological and Histomorphometric Study of the Effect of Strontium Ranelate on the Healing of One-Wall Intrabony Periodontal Defects in Dogs

Intérêt des éponges de collagène pour prévenir la résorption osseuse alvéolaire post-extractionnelle : revue systématique de la littérature

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