Periodontal Treatment Outcomes in Post Menopausal Women Receiving Hormone Replacement Therapy

Çekici, Ali; Başer, Ülkü; Isik, Gulden; Akhan, Süleyman Engin; İşsever, Halim; Onan, Utku

doi:10.17096/jiufd.61637

Cited by 5 publications

(15 citation statements)

References 33 publications

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“…In the study by López‐Marcos et al (), patients received oestrogen‐containing patches combined with low doses of orally administered progesterone. In Çekici et al (), women undergoing HRT received a conjugated combination of oestrogen and medroxyprogesterone acetate (2.5 g, daily). Five studies measured plasma oestrogen levels during study execution (Çekici et al, ; Civitelli et al, ; López‐Marcos et al, ; Payne et al, ; Wang, LaMonte et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…Ronderos et al () recorded the mean of attachment gain (mm) of the participants according to the time of HRT use. Çekici et al () recorded the CAL data as the mean attachment gain (mm) during the first, third and sixth month of study.…”

Section: Resultsmentioning

confidence: 99%

“…The PPD was registered in six sites per tooth of the participants in four studies (Çekici et al, ; Norderyd et al, ; Persson et al, ; Pizzo et al, ). Tarkkila et al () reported PPD on 4 sites per tooth of postmenopausal women while López‐Marcos et al () recorded the deeper value of PPD in each dental surface analysed.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies reported the mean PPD (mm) of each group (Norderyd et al, ; Pizzo et al, ). Çekici et al () recorded the mean PPD (mm) in the first, third and sixth month of study. In the study by Tarkkila et al (), only the number of periodontal pockets with PPD ≥ 6 mm was recorded.…”

Section: Resultsmentioning

confidence: 99%

“…Four observational cross‐sectional studies (Haas et al, ; Norderyd et al, ; Pizzo et al, ; Ronderos et al, ) and one non‐randomized clinical trial (Çekici et al, ) included CAL in their analysis. CAL gain varied from −0.18 to 0.54 mm for HRT+ individuals.…”

Section: Resultsmentioning

confidence: 99%

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Sex hormone replacement therapy in periodontology—A systematic review

et al. 2019

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Objective To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans. Materials and Methods Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/MEDLINE. Human observational and interventional studies that evaluated the following parameters were included: clinical attachment loss (CAL), probing pocket depth (PPD), bleeding on probing (BOP), radiographic bone loss (RBL) or osseointegration. Results Initial search retrieved 1,282 non‐duplicated articles. Fifteen studies were selected after inclusion criteria were applied. All studies were performed in postmenopausal women. Mean differences for PPD reduction ranged from 0.02 to 0.2 mm in HRT‐positive patients; mean CAL gain −0.18 to 0.54 mm; mean RBL reduction −0.87 to 0.15 mm; and mean BOP reduction 9%‐30.3%. Failure rate of dental implants increased −5.5% to 11.21% when HRT was used. Conclusions Very low but consistent evidence suggests a reduction in BOP and no impact on RBL in postmenopausal women receiving HRT. There are inconsistent reports that suggest that HRT in postmenopausal women: (a) improves or does not impact PPD reduction and CAL gain; and (b) does not impact or increase implant loss. In summary, there is no evidence to support HRT prescription for either men or women for periodontal/implant placement purposes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Sex hormone replacement therapy in periodontology—A systematic review

et al. 2019

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Systemic Factors Affecting Prognosis and Outcomes in Periodontal Disease

Sangalli,

Banday,

Sullivan

et al. 2024

Dental Clinics of North America

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Hormone replacement therapy and periodontitis progression in postmenopausal women: A prospective cohort study

Man,

Zhang,

Cheng

et al. 2024

J of Periodontal Research

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ObjectiveThis study aimed to investigate the responses of periodontal environment to hormone replacement therapy (HRT) in postmenopausal women with or without periodontitis.BackgroundHRT is a common and effective strategy for controlling menopausal symptoms, while the changes of periodontal environment under it, particularly in postmenopausal women with periodontitis, remain unclear.MethodsAs a prospective cohort study, a total of 97 postmenopausal women receiving HRT were screened, including 47 with and 50 without periodontitis. Correspondingly, 97 women did not receiving HRT were screened as controls during the same period. The full‐mouth sulcus bleeding index (SBI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were measured using periodontal probes. The levels of interleukin‐6 (IL‐6) and tumor necrosis factor α (TNF‐α) in the gingival crevicular fluid were measured using enzyme‐linked immunosorbent assay. In addition, cone beam computed tomography was performed to measure the alveolar bone height (ABH) and bone mineral density (BMD).ResultsIn postmenopausal women without periodontitis, no significantly changes on periodontal parameters were observed after HRT. In women with stage II periodontitis, SBI, BOP, IL‐6, and TNF‐α were significant decreased after one year and two years of HRT. Compared to the controls, women with stage II periodontitis who underwent HRT had significantly lower CAL and ABH and higher BMD in the second year. The incidence of at least one site with CAL increase ≥1 mm between baseline and 2 years was significantly lower in the HRT group than in the control group in women with stage II periodontitis. In addition, HRT was significantly associated with a decrease in SBI, BOP, IL‐6, and TNF‐α in the first year and with a decrease in CAL, SBI, BOP, IL‐6, and ABH and an increase in BMD in the second year.ConclusionsIn postmenopausal women with stage II periodontitis, HRT is associated with the alleviation of inflammation within two years and the remission of alveolar bone loss in the second year. HRT appears to decrease the incidence of CAL increase ≥1 mm within 2 years in women with periodontitis by inhibiting inflammation and alveolar bone loss.

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Periodontal Treatment Outcomes in Post Menopausal Women Receiving Hormone Replacement Therapy

Cited by 5 publications

References 33 publications

Sex hormone replacement therapy in periodontology—A systematic review

Sex hormone replacement therapy in periodontology—A systematic review

Systemic Factors Affecting Prognosis and Outcomes in Periodontal Disease

Hormone replacement therapy and periodontitis progression in postmenopausal women: A prospective cohort study

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