Periodontal tissue regeneration by combined implantation of adipose tissue-derived stem cells and platelet-rich plasma in a canine model

Concise Review: Mesenchymal Stromal Cells Used for Periodontal Regeneration: A Systematic Review

“…These ADSCs can be easily isolated from intact resected adipose tissue or by using liposuction, and their properties are similar to cells isolated from bone marrow [14, 15]. However, quantitative data regarding the capacity of ADSCs to contribute to periodontal regeneration were sparse at the time of writing [70, 71].…”

Periodontal tissue regeneration by transplantation of rat adipose-derivedstromal cells in combination with PLGA-based solid scaffolds

“…These characteristics suggest that ASCs would be useful as autologous transplant cells for tissue regeneration (11). In fact, several reports of ASCs transplantation for periodontal tissue engineering suggested that these stem cells have the potential to regenerate cementum, alveolar bone, and periodontal ligament structures (53)(54)(55). Three-dimensional (3D) scaffolds are widely recognized as essential for many tissue engineering applications.…”

“…The most extensively used synthetic polymers in tissue engineering studies are poly (glycolic acid), poly (lactic acid), and their copolymers [e.g., (Poly d, l-lactic-co-glycolic acid; PLGA)], which typically offer a higher primary stability and are more amenable to macro/micro-structure formation than natural biomaterials. Previous studies in periodontal tissue engineering demonstrated the value of transplanting ASCs with platelet-rich plasma; however, there is no report of other materials used in combination with ASCs in the study of periodontal tissue regeneration (54,55). A biodegradable PLGA-polymer sponge has been used to deliver cementoblasts in a rat periodontal fenestration model, salt particles (thickness 3 mm) were carefully removed from the molds.…”

Perspectives on regeneration of alveolar bone defects

“…This profoundly affects the field of regenerative medicine. A study showed that after a 3 month healing period, the addition of ASCs to plateletrich plasma (PRP) enhanced the amount of n-ewly formed dog alveolar bone [67], and other studies came to thesimilar conclusions [68,69]. One study compared the use of ASCs and autogenous bone grafts in dogs, bone formation in the maxillary alveolar cleft was higher in the autograft group [70].…”