Periodontal therapy as an adjunctive modality for HbA1c reduction in type-2 diabetic patients

Sundar, Chalini; Ramalingam, Sundar; Mohan, Viswanathan; Pradeepa, Rajendra; Ramakrishnan, Minu

doi:10.4103/jehp.jehp_66_18

Cited by 15 publications

(5 citation statements)

References 27 publications

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“…One of the key factors in treating DM is glycemic control. Previous studies showed that individuals with higher glycated hemoglobin (also known as hemoglobin A1C (HbA1c)) had an increased risk of periodontal disease [ 73 , 74 , 75 ]. The mechanism associated with the two diseases is probably a multifactorial one.…”

Section: Resultsmentioning

confidence: 99%

“…As depicted in this review, in insulin resistance, there is an increase in pro-inflammatory cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-α [ 40 , 52 ] and ROS [ 53 ]. Furthermore, in T2DM there is an increase in TNF-α, IL-1β, IL-6, and IL-18 [ 71 ], which are known to elevate HbA1C, which increases the risk for periodontal disease [ 73 , 74 , 75 ]. Moreover, the inflammatory state is known to activate MMP, which, together with ROS, will result in periodontal breakdown [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

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Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review

Aizenbud,

Wilensky,

Almoznino

2023

IJMS

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Periodontal disease is a complex and progressive chronic inflammatory condition that leads to the loss of alveolar bone and teeth. It has been associated with various systemic diseases, including diabetes mellitus and obesity, among others. Some of these conditions are part of the metabolic syndrome cluster, a group of interconnected systemic diseases that significantly raise the risk of cardiovascular diseases, diabetes mellitus, and stroke. The metabolic syndrome cluster encompasses central obesity, dyslipidemia, insulin resistance, and hypertension. In this review, our objective is to investigate the correlation between periodontal disease and the components and outcomes of the metabolic syndrome cluster. By doing so, we aim to gain insights into the fundamental mechanisms that link each systemic condition with the metabolic syndrome. This deeper understanding of the interplay between these conditions and periodontal disease can pave the way for more effective treatments that take into account the broader impact of managing periodontal disease on the comprehensive treatment of systemic diseases, and vice versa.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review

Aizenbud,

Wilensky,

Almoznino

2023

IJMS

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“…With respect to the review findings reported, there were limitations of heterogeneity in the included study data, mainly about the outcomes assessed and reported, and varying the follow-up periods. Similarly, neither the cases reported, nor the reviewed studies, took into consideration auxiliary modalities such as laser and photodynamic therapy [ 35 ], the effect of systemic illnesses on implant osseointegration and bone healing [ 37 , 38 ], and special scenarios such as immediate implant placement and bone graft sites [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Local Oxygen-Based Therapy (blue®m) for Treatment of Peri-Implant Disease: Clinical Case Presentation and Review of Literature about Conventional Local Adjunct Therapies

Shaheen,

Abas,

Basudan

et al. 2024

Medicina

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Peri-implant diseases including peri-implant mucositis and peri-implantitis are among the major causes of failure of implant-supported dental restorations. They are characterized by progressive inflammation of the peri-implant mucosa, extending to the surrounding connective tissues and leading to bone loss and implant failure. Although strict oral hygiene practices help in preventing peri-implant diseases, plaque buildup around the implant restoration leads to chronic inflammation, due to the adherent bacterial biofilm. While mechanical debridement and non-surgical therapy to remove inflamed connective tissue (ICT) form the mainstay of treatment, additional local adjunctive therapies enhance clinical outcomes. Topical oxygen therapy is known to reduce inflammation, increase vascularity, and act as a bacteriostatic measure. The use of oxygen-based therapy (blue®m) products as a local adjunctive therapy for peri-implant mucositis and peri-implantitis can result in clinical outcomes similar to that of conventional local adjuncts such as chlorhexidine, antibiotics, and antibacterial agents. This report aims to present the clinical findings of patients with peri-implant mucositis and peri-implantitis, who were managed using local oxygen-based therapy as an adjunct to non-surgical therapy. In addition, a review of the literature about commonly used local adjuncts for peri-implant diseases has been included in the report to provide a means of comparison between conventional local adjunct therapy and topical oxygen-based therapy. Based on the reported findings and reviewed literature, local oxygen-based adjunct therapy was equally effective as conventionally used local adjuncts such as antibiotics, antibacterials, and probiotics, in treating patients with peri-implant diseases.

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“…While the present clinical reports were focused mainly on evaluating the clinical outcomes of topical oxygen therapy, its effect on bone level gain could be included in the scope of future clinical trials. Similarly, the role of systemic illnesses and confounding factors such as smoking and parafunctional habits on the development and progression of gingivitis and periodontitis [ 50 ], and how they may be influenced by local oxygen-based therapy, would require further investigation.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Topical Oxygen Therapy in Gingivitis and Periodontitis: Clinical Case Reports and Review of the Literature

Basudan,

Abas,

Shaheen

et al. 2024

JCM

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Gingivitis and periodontitis are common oral pathological conditions. Several optional adjunctive local therapies are used clinically. While antibiotics and chlorhexidine are the most common agents of choice, their long-term use is associated with several adverse effects. Some of these include staining of teeth and restorations, cellular cytotoxicity and hypersensitivity. Topical oxygen therapy has been recently introduced and could be clinically capable of inhibiting plaque bacterial biofilm growth. Available as a mouthwash, toothpaste and oral gel, this formulation comprises cellulose, glycerol and sodium peroxoborate, and releases topical oxygen in a controlled manner. Moreover, it releases topical oxygen, in a controlled manner, and lactoferrin, which are capable of antibacterial action and stimulation of bone cells, respectively. The aim of this paper is to report a case of gingivitis and another case of periodontitis, both of which were successfully treated clinically with adjunctive local oxygen therapy (blue®m). Additionally, this paper aims to review the relevant literature in terms of adjunct topical or local therapies used in the treatment of gingivitis and periodontitis, in order to understand how local therapies are helpful and to know if local oxygen therapy is a suitable clinical alternative.

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Periodontal therapy as an adjunctive modality for HbA1c reduction in type-2 diabetic patients

Cited by 15 publications

References 27 publications

Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review

Periodontal Disease and Its Association with Metabolic Syndrome—A Comprehensive Review

Local Oxygen-Based Therapy (blue®m) for Treatment of Peri-Implant Disease: Clinical Case Presentation and Review of Literature about Conventional Local Adjunct Therapies

Effectiveness of Topical Oxygen Therapy in Gingivitis and Periodontitis: Clinical Case Reports and Review of the Literature

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