Periodontal Status in Morbidly Obese Patients With and Without Obstructive Sleep Apnea Syndrome Risk: A Cross‐Sectional Study

Sales-Peres, Sílvia Helena de Carvalho; Groppo, Francisco Carlos; Rojas, Lida Velazque; Sales-Peres, Matheus de Carvalho; Sales-Peres, Arsênio

doi:10.1902/jop.2016.150587

Cited by 24 publications

(23 citation statements)

References 50 publications

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“…75,76 However, further studies are necessary to understand the role of obesity as a confounding factor. 77 Also, studies to the effect of treatment of OSA on periodontal disease and vice versa are required.…”

Section: Dentist's Role In Obstructive Sleep Apnoeamentioning

confidence: 99%

“…Periodontal disease shares some of these mechanisms, and recent studies have shown a significant association with OSA 75,76 . However, further studies are necessary to understand the role of obesity as a confounding factor 77 . Also, studies to the effect of treatment of OSA on periodontal disease and vice versa are required.…”

Section: Obstructive Sleep Apnoea: the Dentist's Rolementioning

confidence: 99%

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The face of Dental Sleep Medicine in the 21st century

Lobbezoo

Lavigne

Kato

et al. 2020

J of Oral Rehabilitation

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We spend a significant proportion of our lives sleeping. Unfortunately, some of us suffer from sleep disorders, which can affect quality of life considerably. While most sleep disorders should be diagnosed and treated by medical doctors, it becomes increasingly clear that some disorders have important diagnostic and/or management links to the dental domain, hence the emergence of the discipline 'Dental Sleep Medicine' in dentistry. Dental Sleep Medicine is concerned with the study of the oral and maxillofacial causes and consequences of sleep-related problems. 1 Already more than twenty years ago, Prof. Lavigne and coworkers published a comprehensive review, entitled 'Sleep disorders and the dental patient', in which several common sleep disorders of interest

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Section: Dentist's Role In Obstructive Sleep Apnoeamentioning

confidence: 99%

Section: Obstructive Sleep Apnoea: the Dentist's Rolementioning

confidence: 99%

The face of Dental Sleep Medicine in the 21st century

Lobbezoo

Lavigne

Kato

et al. 2020

J of Oral Rehabilitation

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“…Adipose cells secrete bioactive molecules (adipokines) such as leptin, adiponectin, visfatin and resistin that are elevated in obese individuals (Luo and Blackledge 2018). These cells also secrete elevated inflammatory cytokines such as TNF-α, IL-6, and other bioactive molecules including inhibitor of plasmogen activator-1 (PAI-1, involved in vascular homeostasis), angiotensinogen (ANG, regulators of blood pressure), vascular endothelial growth factor (VAGF, promotor of angiogenesis) and acute phase C-reactive protein (CRP) (Sales-Peres et al 2016). Leptin is thought to be a key regulator of innate and adaptive immunity and thus enhances obesity-associated and inflammatory diseases that affect bones and joints (Francisco et al 2018).…”

Section: Impact Of Obesity On the Immune Responsementioning

confidence: 99%

The Association between Periodontal Disease and Obesity: Roles of the Dysbiotic Microbiome and Inflammation

Hashim¹

2020

SJKFU

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Periodontal disease and obesity are highly prevalent conditions in the developed and developing countries, and recent studies have suggested their association. However, it is not clear whether this association is due to common risk factors or there are underlying molecular and cellular mechanisms linking both conditions. The keystone-pathogen hypothesis holds that administration of the periodontal pathogen Porphyromonas gingivalis in the oral cavity of murine models led to low colonisation but transformed the health-associated (symbiotic) microbiota to a disease-causing (dysbiotic) state. This shift causes qualitative and quantitative changes in the oral microbiome and breakdown of the host's homeostatic balance and initiation of periodontitis (Hajishengallis et al., 2011). The second hypothesis suggests the link between periodontitis and obesity is largely based on the oral cavity-gut microbiome connection. Administration of P. gingivalis in rodent models altered the composition of the gut microbiome from one of health to disease. These changes resulted in impaired gut barrier function, endotoxemia and inflammation of the liver and adipose tissue (Arimatsu et al., 2014); (Nakajima et al., 2015). This review aims to discuss and assess the available literature in regard to both hypotheses, and the potential mechanisms that are necessary for linking both diseases. In the author's opinion, the available literature partly supports the mechanistic link between obesity and periodontitis through a dysbiotic microbiome and inflammation. This warrant-targeted research to identify the common pathogenic bacteria or other keystone pathogens that drive dysbiosis and orchestrate inflammatory disease for the development of novel diagnostics and treatment modalities. 184 ‫هاشم‬ ‫أحمد‬ (. 2020 .) ‫وااللتهابات‬ ‫الجرثومي‬ ‫املايكروبيوم‬ ‫دور‬ ‫والسمنة:‬ ‫املزمن‬ ‫اللثة‬ ‫التهاب‬ ‫مرض‬ ‫بين‬ ‫العالقة‬. ‫العلوم‬ ‫فرع‬ ‫فيصل،‬ ‫امللك‬ ‫لجامعة‬ ‫العلمية‬ ‫املجلة‬ ‫والتطبيقية‬ ‫األساسية‬ ، (‫املجلد‬ 21 (‫العدد‬ ،) 2)

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“…Obstructive sleep apnea additionally leads to daytime symptoms of functional impairment, such as impaired alertness (Young et al 1993;Tanaka and Shima 2010). Sleep apnea syndrome is associated with general health complications, including cardiovascular disease, hypertension, and diabetes mellitus, as well as oral complications, such as periodontitis (Elmasry et al 2000;Peppard et al 2000;Shahar et al 2001;Tanigawa et al 2004;Sales-Peres et al 2016). The Epworth sleepiness scale (ESS) is a representative self-reported questionnaire that consists of 8 items for measuring human daytime sleepiness.…”

Section: Introductionmentioning

confidence: 99%

“…Several previous studies have already investigated the relationships between oral status and ESS scores. For instance, a research group reported finding no association between the ESS score and periodontal status in morbidly obese patients (Sales-Peres et al 2016). In addition, another group reported that patients with burning mouth syndrome, a chronic disease characterized by a burning sensation and pain in the oral cavity, exhibited significant decreases in the ESS score, as compared with a healthy control group (Lopez-Jornet et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Gustatory Salivation Is Associated with Body Mass Index, Daytime Sleepiness, and Snoring in Healthy Young Adults

Izumi

Hong

Iwasaki³

et al. 2016

Tohoku J. Exp. Med.

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The taste detection system for oral fatty acid may be related to obesity. In addition, sleep is intrinsically and closely related to food intake and metabolism. However, the association of gustatory salivation with body mass index (BMI), daytime sleepiness, or sleep habits is largely unknown. Therefore, we evaluated the relationship between gustatory salivation and BMI, Epworth sleepiness scale (ESS, a daytime sleepiness scale) or sleep habits among 26 healthy young individuals (20 males and 6 females; mean age: 26.0 ± 4.3 years). We also measured the saliva flow rate (SFR) that was induced by gum-chewing or each of three prototypical tastants (acetic acid, sucrose, and NaCl). Further, the SFR was induced by fatty acid, provided as oleic acid (OA) homogenized in non-fat milk. All participants showed normal rates of salivation during resting and gum-chewing states. The increase in the SFR induced by OA, but not by each of the three tastants, was associated with BMI. Moreover, both daytime sleepiness level and frequency of snoring were associated with the increase in the SFR induced by NaCl. These results suggest that BMI is associated with salivation induced by oral fatty acid exposure. Additionally, the regulatory mechanism for the NaClinduced salivation reflex may have a relationship with impairments of the respiratory control system that are related to snoring during sleep and lead to daytime sleepiness because of insufficient sleep. Thus, measurement of gustatory salivation might contribute to the evaluation and prevention of obesity and sleeprelated breathing disorders.

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Periodontal Status in Morbidly Obese Patients With and Without Obstructive Sleep Apnea Syndrome Risk: A Cross‐Sectional Study

Abstract: There was no association between periodontal disease and OSAS risk in Class III obese patients, but OSAS risk was associated with both NC and PPNC.

Cited by 24 publications

References 50 publications

The face of Dental Sleep Medicine in the 21st century

The face of Dental Sleep Medicine in the 21st century

The Association between Periodontal Disease and Obesity: Roles of the Dysbiotic Microbiome and Inflammation

Gustatory Salivation Is Associated with Body Mass Index, Daytime Sleepiness, and Snoring in Healthy Young Adults

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