Periodontal status and bacteremia with oral viridans streptococci and coagulase negative staphylococci in allogeneic hematopoietic stem cell transplantation recipients: a prospective observational study

Raber-Durlacher, Judith E.; Laheij, Alexa M. G. A.; Epstein, Joel B.; Epstein, Matthew S.; Geerligs, Gerard M.; Wolffe, G. N.; Blijlevens, Nicole M A; Donnelly, J. Peter

doi:10.1007/s00520-012-1706-2

Cited by 53 publications

(48 citation statements)

References 44 publications

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“…115 Dental plaque is a well-documented cause of gingivitis 116 and is significantly associated with bacteremia in healthy subjects 117 and HCT patients. 118 Interestingly, a meta-analysis confirms that plaque accumulation and gingival inflammation score significantly to increase BSI risk following tooth brushing in healthy subjects. 119 However, how dental plaque contributes to mucositis in HCT patients remains unstudied.…”

Section: Bloodstream Infection Preventionmentioning

confidence: 91%

“…121,[125][126][127] In a small prospective evaluation of periodontal disease in adult HCT recipients, periodontal status correlated with frequency of bacteremia, particularly due to viridans streptococci and Staphylococcus epidermidis. 118 Recent oral care guidelines recommend brushing with an ultra-soft toothbrush two to three times daily and using non-flavored chlorhexidine gluconate 0.12-0.2% solution as an oral antiseptic twice daily when oral hygiene is suboptimal after HCT. 128 Adjunctive therapies with some supporting evidence include the use of KGF, patient-controlled analgesia and low-level laser therapy for mucositis prevention in patients receiving high-dose chemotherapy or irradiation for HCT.…”

Section: Bloodstream Infection Preventionmentioning

confidence: 99%

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Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis

Dandoy

Ardura

Papanicolaou

et al. 2017

Bone Marrow Transplant

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Bacterial bloodstream infections (BSI) cause significant transplant-related morbidity and mortality following allogeneic hematopoietic cell transplantation (allo-HCT). This manuscript reviews the risk factors for and the bacterial pathogens causing BSIs in allo-HCT recipients in the contemporary transplant period. In addition, it offers insight into emerging resistant pathogens and reviews clinical management considerations to treat and strategies to prevent BSIs in allo-HCT patients.

show abstract

Section: Bloodstream Infection Preventionmentioning

confidence: 91%

Section: Bloodstream Infection Preventionmentioning

confidence: 99%

Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis

Dandoy

Ardura

Papanicolaou

et al. 2017

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…The incidence and the magnitude of bacteremia that occurs following chewing, tooth brushing, and invasive dental procedures are associated with gingival inflammation rather than with pocket depths (19). Bacteremia originating from the oral cavity is caused by a wide variety of microorganisms, including Gram-negative anaerobes and the VGS (17).…”

Section: Periodontitis and Bacteremiamentioning

confidence: 99%

Periodontitis, Bacteremia and Infective Endocarditis: A Review Study

Dhotre

Davane

Nagoba

2017

Arch Pediatr Infect Dis

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Context: Earlier evidences show that periodontitis with inflamed and ulcerated crevicular or pocket epithelium surrounding the teeth may be a portal of entry for bacteria into the bloodstream. A newly proposed causal model predicts that an early bacteremia may affect the endothelial surface of the heart over many years and promote valve thickening rendering the heart valve susceptible to vegetation by a later bacteremia that would culminate over a few weeks into fulminant infection. Evidence Acquisition: In this review, various published sources of information pertaining to periodontitis, bacteremia and infective endocarditis were reviewed. This review is focused on the role of the viridans group streptococci (VGS) in periodontitis, bacteremia and infective endocarditis. Results: The viridans group streptococci present in the oral cavity were the most important causes of bacteremia following dental procedures and infective endocarditis. In most of the studies, significantly higher rates of bacteremia occurring in patients with periodontitis than patients without periodontitis indicated that periodontitis opens up the route for oral streptococci to gain entry into the bloodstream. In addition, the significantly higher rates of isolation of the VGS from the patients of infective endocarditis with periodontitis showed that there was a positive association between periodontitis, infective endocarditis and the VGS. Conclusions:The literature survey presented in this review suggests that there is a definite relation between periodontitis, bacteremia and infective endocarditis and would provide valuable data for the future dentists as well as the physicians, because a large proportion of the world's population lives a lifetime with periodontitis. Moreover, infective endocarditis still remains a cause of concern as this disease is a cause of considerable morbidity and mortality regardless of modern antimicrobial and surgical treatment.

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“…[28]. Transitory bacteremia is detectable from 100 to 50% in healthy subjects after surgical acts, for example: dental extraction, tonsillectomy or third-molar surgery respectively.…”

Section: Oral Surgery and Risk For Bacteremiamentioning

confidence: 99%

Oral Surgery in the Human Microbiota Era the role of Periodontal Bacteria

Mascolo¹

2017

oajs

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Periodontal status and bacteremia with oral viridans streptococci and coagulase negative staphylococci in allogeneic hematopoietic stem cell transplantation recipients: a prospective observational study

Cited by 53 publications

References 44 publications

Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis

Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis

Periodontitis, Bacteremia and Infective Endocarditis: A Review Study

Oral Surgery in the Human Microbiota Era the role of Periodontal Bacteria

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