Periodontal Regeneration

Mancini, Leonardo; Fratini, Adriano; Marchetti, Enrico

doi:10.3390/encyclopedia1010011

Cited by 9 publications

(13 citation statements)

References 71 publications

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“…The decalcifying process of FDBA makes bone morphogenetic proteins (BMP) available for effective bone regeneration [70], while the freeze-drying process lowers the antigenicity. Bone turnover and integration of FDBA or DFDBA at recipient site can be improved by directly administering biological mediators like platelet-rich growth factors (PDGF), BMP, enamel matrix derivatives (EMD), vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF) at the time of augmentation [68,71,72].…”

Section: Craniofacial and Alveolar Bone Regenerationmentioning

confidence: 99%

“…More specifically, these membranes exclude epithelial cells from infiltrating into the bony defects [113]. Any combination of bone fillers, membranes, and biologics can be directly administered in the defect to regenerate new alveolar bone, cementum and PDL [72]. The ideal properties of membrane should respect several key principles: (1) biocompatibility, (2) cell exclusion, (3) space maintenance, and (4) clinical handling [71,72].…”

Section: Temporomandibular Joint Reconstructionmentioning

confidence: 99%

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Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

Munguia-Lopez

Cho

et al. 2021

Molecules

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Dental, oral, and craniofacial (DOC) regenerative medicine aims to repair or regenerate DOC tissues including teeth, dental pulp, periodontal tissues, salivary gland, temporomandibular joint (TMJ), hard (bone, cartilage), and soft (muscle, nerve, skin) tissues of the craniofacial complex. Polymeric materials have a broad range of applications in biomedical engineering and regenerative medicine functioning as tissue engineering scaffolds, carriers for cell-based therapies, and biomedical devices for delivery of drugs and biologics. The focus of this review is to discuss the properties and clinical indications of polymeric scaffold materials and extracellular matrix technologies for DOC regenerative medicine. More specifically, this review outlines the key properties, advantages and drawbacks of natural polymers including alginate, cellulose, chitosan, silk, collagen, gelatin, fibrin, laminin, decellularized extracellular matrix, and hyaluronic acid, as well as synthetic polymers including polylactic acid (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), poly (ethylene glycol) (PEG), and Zwitterionic polymers. This review highlights key clinical applications of polymeric scaffolding materials to repair and/or regenerate various DOC tissues. Particularly, polymeric materials used in clinical procedures are discussed including alveolar ridge preservation, vertical and horizontal ridge augmentation, maxillary sinus augmentation, TMJ reconstruction, periodontal regeneration, periodontal/peri-implant plastic surgery, regenerative endodontics. In addition, polymeric scaffolds application in whole tooth and salivary gland regeneration are discussed.

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Section: Craniofacial and Alveolar Bone Regenerationmentioning

confidence: 99%

Section: Temporomandibular Joint Reconstructionmentioning

confidence: 99%

Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

Munguia-Lopez

Cho

et al. 2021

Molecules

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“…One surgical treatment approach that is often applied and has proven successful in increasing tissue regeneration is the guided tissue regeneration (GTR) and guided bone regeneration (GBR) methods. [1][2][3][4] Membrane barrier usage was commenced when the GTR concept was introduced, with its main function to inhibit epithelial cells migration by placing the membrane between the flap and root surface, thereby preventing connective tissue contact and isolating the cells to restore the periodontal ligament, cementum, and connective tissue. 5,6 In general, barrier membranes are divided into two, namely nonresorbable and resorbable.…”

Section: Introductionmentioning

confidence: 99%

Determination of the Sterilization Dose of Gamma-Ray Irradiation for Polyvinyl Alcohol-Collagen-Chitosan Composite Membrane as a Material for Periodontal Regenerative Surgery

et al. 2023

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Objective Membrane sterility is very necessary considering its function as an implant material. Therefore, this research aims to determine the dose of gamma-ray irradiation for the sterilization of polyvinyl alcohol (PVA)–collagen–chitosan composite membranes used as regenerative surgery materials. Materials and Methods A total of 100 pieces of the composite membranes were prepared in a size of 2.0 × 1.5 cm by mixing 7.5% PVA, 3% collagen, and 2% chitosan using the film casting method in three batches. Furthermore, the bioburden test was performed to determine the initial microbial count in the sample by following ISO 11737-1. The results were used to ascertain the dose of gamma-ray irradiation on the sample according to ISO 11137-2. The dose verification test was then performed at the sterility assurance level 10−6. Results The average result of the bioburden test from three batches was 6.6 colony forming unit; hence, the verification dose was 4.8 kGy. In the verification dose test, since there was only one contaminated sample, the sterility dose test was continued. Conclusion The sterile gamma-ray irradiation dose for PVA–collagen–chitosan composite membrane was 17.1 kGy.

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“…Other modifications induced by EMD are represented by increased production of PGE2 and OPG, proliferation and migration of T-lymphocytes, and a decreased production of IL-1b, IL-8 [11]. Besides influencing wound healing by downregulating inflammatory genes, while upregulating growth and repair-promoting genes, EMD has been demonstrated to encourage angiogenesis by the activation of endothelial cells [16][17][18][19], and it also stimulates microvascular cell differentiation [11]. There is evidence that EMD exerts a significant influence on the behavior of periodontal ligament cells, osteoblasts, cementoblasts, gene expression by regulating cell attachment, proliferation, and differentiation [13].…”

Section: Introductionmentioning

confidence: 99%

“…Enamel matrix derivate found its application in periodontology, being used for regenerative procedures, in order to stimulate wound healing, cementum and bone formation [17,18]. So far, EMD has been used in patients without systemic disease, showing great results.…”

Section: Introductionmentioning

confidence: 99%

The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions

et al. 2021

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Background and Objectives: Enamel matrix derivative (EMD) is a biomaterial used for periodontal regenerative therapy due to its properties of stimulating cementum development and bone synthesis. Diabetes is a chronic condition that affects healing and predisposes to infection. The aim of this review was to evaluate the current studies available on the application and results of EMD for periodontal regenerative therapy under diabetic conditions. Materials and Methods: Five databases (PubMed, ResearchGate, Scopus, Web of Science and Google Scholar) were searched for relevant articles, using specific keywords in different combinations. The inclusion criteria were clinical trials, case reports, case studies, and animal studies published in English, where periodontal treatment for bone defects includes EMD, and it is performed under diabetic conditions. Results: Of the 310 articles resulted in search, five studies published between 2012 and 2020 met the inclusion criteria and were selected for the current review. In human studies, the use of EMD in infrabony defects showed favorable results at follow-up. In animal studies, periodontal regeneration was reduced in diabetic rats. Conclusions: EMD might promote bone healing when used under diabetic conditions for the regenerative periodontal therapy. Due to limited number of studies, more data are required to sustain the effects of EMD therapy in diabetic settings.

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Periodontal Regeneration

Abstract: Periodontal regeneration is a technique that aims to regenerate the damaged tissue around periodontally compromised teeth. The regenerative process aims to use scaffolds, cells, and growth factors to enhance biological activity.

Cited by 9 publications

References 71 publications

Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

Polymeric Scaffolds for Dental, Oral, and Craniofacial Regenerative Medicine

Determination of the Sterilization Dose of Gamma-Ray Irradiation for Polyvinyl Alcohol-Collagen-Chitosan Composite Membrane as a Material for Periodontal Regenerative Surgery

The Outcomes of Enamel Matrix Derivative on Periodontal Regeneration under Diabetic Conditions

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