Periodontal Pocket Treatment in Beagle Dogs Using Subgingival Doxycycline From a Biodegradable System. I. Initial Clinical Responses

Southard, G. L.; Dunn, Richard L.; Yewey, G. L.; Godowski, Kenneth C.; Polson, Alan M.; Fulfs, J. C.; Laster, Larry L.

doi:10.1902/jop.1996.67.11.1176

Cited by 42 publications

(25 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This substantiates the different studies which also advocate that SRP is an initial gold standard treatment strategy for periodontal diseases. [303132] A striking observation was a significant reduction in PPD between 3 and 6 months in Group II ( P = 0.043), whereas in Group I, it was nonsignificant ( P = 0.326). Similarly, there was a slight gain in CAL between 3 and 6 months, which was insignificant statistically ( P = 0.326) in Group I, but in Group II, a significant gain in CAL continued during this period of 3–6 months ( P = 0.023).…”

Section: Discussionmentioning

confidence: 97%

Clinical efficacy of subgingivally delivered simvastatin gel in chronic periodontitis patients

Agarwal

Chaubey

et al. 2016

J Indian Soc Periodontol

View full text Add to dashboard Cite

Background:Simvastatin (SMV), a new locally delivered drug of class statins, is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Statins, besides having lipid-lowering abilities, also have pleiotropic effects like host modulation and bone regeneration. The present study was designed to investigate the effectiveness of SMV, 1.2 mg, in an indigenously prepared biodegradable controlled-release gel as an adjunct to scaling and root planing (SRP).Materials and Methods:A total of 60 sites, with pocket depth ≥5 mm, two from each of 30 patients after SRP, were categorized into two treatment groups, for subgingival placement of placebo (Gp 1) or SMV (Gp 2). Clinical parameters were recorded at baseline and at 1, 3 and 6 months comprising plaque index, gingival index, probing pocket depth (PPD) and clinical attachment level (CAL). The osseous changes were evaluated radiographically by measuring vertical gain, INFRA 1 and angle of the defect, INFRA 2 from baseline to 6 months.Results:All subjects tolerated the drug, without any post-application complication. The treatment improved the periodontal condition in both the groups but significant reductions in PPD (p= 0.04), and INFRA 1 (p= 0.000), along with gain in CAL (p= 0.02) and INFRA 2 (p= 0.000) were observed in Gp 2. In one site, an unexpected 5 mm decrease in INFRA 1 was found.Conclusion:Local drug delivery of SMV enhanced the beneficial effect of SRP, in pocket reduction, gain in CAL and bone fill.

show abstract

Section: Discussionmentioning

confidence: 97%

Clinical efficacy of subgingivally delivered simvastatin gel in chronic periodontitis patients

Agarwal

Chaubey

et al. 2016

J Indian Soc Periodontol

View full text Add to dashboard Cite

show abstract

“…Many studies on clinical effects of both systemic and local tetracyclines have been performed. In some of these studies, tetracyclines made no statistically significant difference on probing depths and clinical attachment levels (10,11,(14)(15)(16)(17)(18)(19) while in others successful clinical results were obtained by tetracycline and minocycline treatments (20)(21)(22)(23)(24)(25)(26)(27)(28). These studies evaluated only systemic or local antibiotic treatments with or without mechanical periodontal treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Oral Sci. 46, [25][26][27][28][29][30][31][32][33][34][35] 2004) Key Words: tetracycline; systemic doxycycline; local doxycycline; periodontal treatment; local drug delivery; chronic periodontitis. …”

mentioning

confidence: 99%

A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

et al. 2004

View full text Add to dashboard Cite

In this study, the clinical efficacies of systemic doxycycline (SD) and local doxycycline (LD) in the treatment of chronic periodontitis were compared. Forty-five patients were studied in 3 main groups with 5 treatments: SD alone, SD+scaling-root planing (SD+SRP), LD alone, LD+SRP and SRP alone. Antibiotic-treated patients were given doxycycline treatment alone in 1 quadrant of their upper jaws, and doxycycline+SRP was given in the contralateral quadrant. The areas included at least 4 teeth with ≥ 5 mm pockets. Probing depth (PD), clinical attachment level, gingival index, sulcular bleeding index and plaque index values were recorded at baseline and the 7 th week. The results were statistically analyzed. All of the clinical parameters were significantly reduced by all treatments (P ≤ 0.05). The SD and LD treatments alone provided significant clinical healings. The significant differences among the groups were only in PD at the 7th week. The LD treatment provided significantly higher PD reduction than the SD treatment (P ≤ 0.05). No significant difference was found between the SD+SRP and the LD+SRP treatments. There was no significant difference between SD+SRP and SRP alone treatment (P > 0.05). The SD group showed lower PD reduction than SRP group (P ≤ 0.05), while no significant difference was found between LD and SRP treatments. The LD alone treatment seemed more effective than SD alone treatment on PD reduction, but no significant difference was found between them when combined with the SRP. LD may be more preferable than SD as an adjunct to mechanical treatment since LD seems more effective than SD on PD reduction and does not have the side effects of SD. (J. Oral Sci. 46, [25][26][27][28][29][30][31][32][33][34][35] 2004) Key Words: tetracycline; systemic doxycycline; local doxycycline; periodontal treatment; local drug delivery; chronic periodontitis. IntroductionCurrently, periodontal disease is accepted as an infection of the periodontium since the primary etiologic factor is bacteria, which triggers the host immune response and the consequent tissue destruction. Because of its infectious nature, in a biological view, the main target for periodontal treatment must be the suppression of the effective bacteria (1,2). In light of this conceptual development, it recently has been considered that mechanical treatment alone is insufficient in the periodontal treatment strategy. Antimicrobial therapy, especially antibiotic treatment, is of special importance as an adjunct to mechanical periodontal treatment (1,3,4).To date, the most widely used antibiotics in the treatment of periodontal disease have been tetracyclines since they show the highest concentrations in gingival crevicular fluid (GCF) and are highly effective on Actinobacillus Actinomycetemcomitans (Aa) (5,6). Recently, some nonJournal of Oral Science, Vol. 46, No. 1, 25-35, 2004 7,8). In one of the studies, patients with moderate chronic periodontitis were administered doxycycline for 2 weeks prior to a full-thickness flap procedur...

show abstract

“…Some periodontal topical antibiotics, such as doxycycline, have been proven to increase gingival attachment between 40-50% in pockets with more than 4 mm depth within 12 weeks of treatment (Polson et al 1996;Zetner & Rothmueller 2002). In the present study the effectiveness of CHX for stimulating periodontal attachment was not evaluated due to the limitation of using an equine periodontal probe.…”

Section: Discussionmentioning

confidence: 99%

“…DHL is available as a veterinary medical product formulated as a flowable polymer that rapidly hardens when exposed to water and remains in a periodontal pocket for several weeks (Doxirobe® Gel, Zoetis, New Jersey, U.S.A.). In DHL treated dogs with periodontitis, a substantial improvement in periodontal attachment, reduced periodontal pocket depth and bleeding was shown after 6 weeks to 4 months (Polson et al 1996;Zetner & Rothmueller 2002).…”

Section: Doxycycline Hydrochloride (Dhl)mentioning

confidence: 99%

Clinical and microbiological aspects of periodontal disease in horses in South-East Queensland, Australia

Chinkangsadarn¹

View full text Add to dashboard Cite

The study of periodontal disease as part of equine dentistry is one of the overlooked fields of study, which truly needs more study and research to clearly understand the nature of the disease, the most appropriate diagnostic technique and prevention or treatment to provide for a good quality of life for horses.The abattoir survey of the oral cavity and dentition of 400 horses from SouthEast Queensland, Australia, showed that the most common dental abnormality was sharp enamel points (55.3% prevalence). Several types of dental abnormalities were strongly associated with age. The highest frequency of dental abnormalities (97.5%) were observed in senior horses (11-15 years old) and this included periodontal disease that increased to almost fifty percent in senior horses. The findings also confirmed that all horses, not just young horses, should have regular complete dental examinations as early as possible which should limit the development of more severe dental pathologies later in life.The equine oral microbiome found in dental plaque can cause oral disease which involves the some of the endogenous oral microbiota becoming opportunistic pathogens. The conventional method of oral microbiology based on culture dependent techniques usually overestimates the significance of species that are easily grown and overlooks microbial community diversity. Recently, the culture independent techniques using the next generation sequencing (NGS) method can determine the whole bacterial microbiota. The results from culture dependent and NGS method of analysis of healthy gingiva and periodontitis samples showed that the most common Genera isolated were Prevotella and Porphyromonas without a statistical significance in bacterial diversity, between the control and periodontitis groups. In conclusion, equine bacterial diversity between the healthy and periodontitis groups were similar which is different from other animals and this may be due to factors such as dentition, feed type and husbandry.The standard approach for diagnosis of equine periodontal disease (EPD) is based on clinical dental examination but to evaluate the current stage of disease and for further treatment planning, auxiliary aids such radiography are required. Equine dental radiography has been largely restricted to extraoral techniques by the standard equine radiography technology and the complexity of equine head anatomy. In III addition, superimposition and distortion of the cheek teeth arcade is a major problem for radiographic interpretation. Intraoral radiography has been largely ignored in horses, due to the uncooperative nature of these patients and the absence of dedicated technology unsuitable for equine oral radiography. In this study, radiographic images from seven horse heads obtained using a commercially available equine intraoral computed radiography system (IO-CR) and 3D imaging from computed tomography file sets were reviewed. IO-CR has shown potential as a diagnostic tool where key pathological lesions of EPD of the cheek teeth were demon...

show abstract

Periodontal Pocket Treatment in Beagle Dogs Using Subgingival Doxycycline From a Biodegradable System. I. Initial Clinical Responses

Cited by 42 publications

References 78 publications

Clinical efficacy of subgingivally delivered simvastatin gel in chronic periodontitis patients

Clinical efficacy of subgingivally delivered simvastatin gel in chronic periodontitis patients

A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

Clinical and microbiological aspects of periodontal disease in horses in South-East Queensland, Australia

Contact Info

Product

Resources

About