Periodontal Microbiota in Patients With Coronary Artery Disease Measured by Real‐Time Polymerase Chain Reaction: A Case‐Control Study

Nonnenmacher, Claudia; Stelzel, Michael; Susin, Cristiano; Sattler, Alexander M.; Schaefer, Juergen R.; Maisch, Bernhard; Mutters, Reinier; Flores-de-Jacoby, L

doi:10.1902/jop.2007.060345

Cited by 46 publications

(49 citation statements)

References 31 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other markers of periodontitis include evaluations of subgingival microbial colonization by selected periodontal organisms [15][16][17][18] and levels of serum IgG or IgA antibodies to selected periodontal bacteria. 19 -26 A positive correlation between extent and severity of PD and increased levels of colonization by specific microbial species is widely accepted 27,28 ; in contrast, the association between periodontal pathology and elevated antibody titers to putative pathogens is highly variable.…”

Section: Pathophysiologymentioning

confidence: 99%

Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?

Lockhart

Bolger²,

Papapanou³

et al. 2012

Circulation

879

827

View full text Add to dashboard Cite

Abstract-A link between oral health and cardiovascular disease has been proposed for more than a century. Recently, concern about possible links between periodontal disease (PD) and atherosclerotic vascular disease (ASVD) has intensified and is driving an active field of investigation into possible association and causality. The 2 disorders share several common risk factors, including cigarette smoking, age, and diabetes mellitus. Patients and providers are increasingly presented with claims that PD treatment strategies offer ASVD protection; these claims are often endorsed by professional and industrial stakeholders. The focus of this review is to assess whether available data support an independent association between ASVD and PD and whether PD treatment might modify ASVD risks or outcomes. It also presents mechanistic details of both PD and ASVD relevant to this topic. The correlation of PD with ASVD outcomes and surrogate markers is discussed, as well as the correlation of response to PD therapy with ASVD event rates. Methodological issues that complicate studies of this association are outlined, with an emphasis on the terms and metrics that would be applicable in future studies. Observational studies to date support an association between PD and ASVD independent of known confounders. They do not, however, support a causative relationship. Although periodontal interventions result in a reduction in systemic inflammation and endothelial dysfunction in short-term studies, there is no evidence that they prevent ASVD or modify its outcomes. (Circulation. 2012;125:2520-2544.)

show abstract

Section: Pathophysiologymentioning

confidence: 99%

Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?

Lockhart

Bolger²,

Papapanou³

et al. 2012

Circulation

879

827

View full text Add to dashboard Cite

show abstract

“…30) A case-control study among males aged 48 to 80 years by Nonnenmacher, et al documented a significantly higher frequency of subgingival P. intermedia in patients with coronary artery disease when compared to the Vol 53 No 4 PERIODONTAL BACTERIA AND CORONARY HEART DISEASE controls, after adjusting for smoking. 31) Further, Spahr, et al found a markedly higher number of P. intermedia in the subgingival biofilm of 43 to 73 year-old patients with CHD compared to age-and sex-matched controls. All these findings support our current results.…”

Section: Discussionmentioning

confidence: 96%

“…Although serum antibody levels are considered stable over time, clinical periodontal status was not available, and it is not known whether the levels of antibody to periodontal organisms are the result of a prior incident or to active infection in the study population. In addition, information on remaining teeth, an important confounder for the antibody values, 31) was missing. Further, only 3 periodontopathic species were investigated in this study, and antibody responses to other kinds of bacteria and their role in CHD incidence are unknown.…”

Section: Discussionmentioning

confidence: 99%

Prediagnostic Plasma Antibody Levels to Periodontopathic Bacteria and Risk of Coronary Heart Disease

et al. 2012

View full text Add to dashboard Cite

SummaryMany epidemiological studies have indicated that periodontitis is an important risk factor for coronary heart disease (CHD). We examined whether plasma antibody levels to 3 major periodontal pathogens, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia predicted the risk of CHD events.A nested case-control research design (case: n = 191, control: n = 382), by matching gender, age, study area, date of blood collection, and time since last meal at blood collection, was employed in a large cohort of Japanese community residents.Antibody levels of periodontopathic bacteria were associated with risk of CHD after adjusting for BMI, smoking status, alcohol intake, history of hypertension, history of diabetes mellitus, exercise during leisure time, and perceived mental stress. The association was different by age subgroup. For subjects aged 40-55 years, the medium (31.7-184.9 U/ mL) or high tertile plasma antibody level (> 184.9 U/mL) of A. actinomycetemcomitans showed higher risk of CHD (medium: OR = 3.72; 95% CI = 1.20-11.56, high: OR = 4.64; 95% CI = 1.52-14.18) than the low tertile level (< 31.7 U/ mL). The ORs of CHD incidence became higher with an increase in IgG level of A. actinomycetemcomitans (P for trend = 0.007). For subjects aged 56-69 years, the high tertile level (> 414.1 U/mL) of P. intermedia was associated with higher risk of CHD (OR = 2.65; 95% CI = 1.18-5.94) in a dose-response fashion (P for trend = 0.007).The possible role of periodontopathic bacteria as a risk factor for CHD incidence was suggested by the results of this study by the elevated antibody level to these bacteria with the increased risk of CHD. (Int Heart J 2012; 53: 209-214)

show abstract

“…23 For the purpose of epidemiological studies, 3 clinical parameters are typically recorded to assess the prevalence of PD: (1) Bleeding on probing, (2) pocket depth, and (3) clinical attachment level, which reflects the amount of periodontal tissue loss. 3 Other markers of periodontitis include detection of subgingival microbial colonization by selected periodontal organisms [24][25][26][27] and evaluation of serum IgG or IgA antibodies to selected periodontal bacteria [28][29][30][31][32][33][34][35] . to 10-fold higher rates of myocardial infarction and death before the age of 40 years.…”

Section: (Figure 1)mentioning

confidence: 99%

Link between Periodontal Disease and Coronary Artery Disease: Bangladesh Perspective

et al. 2014

View full text Add to dashboard Cite

Coronary artery disease (CAD) is an increasingly important medical and public healthproblem, and is the leading cause of mortality in Bangladesh. Besides conventional risk factors and ethnicity, a number of emerging risk factors may explain the undue prevalence of CAD in this population. Periodontal disease (PD) is one of them, with prevalence of approximately 50%. As with many other diseases, PD is associated with CAD, and the association is independent of conventional risk factors. Low socioeconomic condition, illiteracy and ignorance, metabolic syndrome, nutritional deficiencies including hypovitaminosis D presumably contribute to the prevalence of PD in Bangladesh. In fact, PD and CAD share some cardiometabolic risk factors including diabetes mellitus, obesity and metabolic syndrome. Future research will hopefully explore different aspects of both public health problems, namely, PD and CAD in the country. The information gathered thereby, will help formulate policy to promote good oral health and tackle the deadly epidemic of CAD more efficiently. DOI: http://dx.doi.org/10.3329/cardio.v7i1.20800 Cardiovasc. j. 2014; 7(1): 44-54

show abstract

Periodontal Microbiota in Patients With Coronary Artery Disease Measured by Real‐Time Polymerase Chain Reaction: A Case‐Control Study

Abstract: The results suggest that a relationship between periodontal disease and coronary heart disease exists, although P. intermedia was the only periodontopathogen related to CAD.

Cited by 46 publications

References 31 publications

Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?

Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association?

Prediagnostic Plasma Antibody Levels to Periodontopathic Bacteria and Risk of Coronary Heart Disease

Link between Periodontal Disease and Coronary Artery Disease: Bangladesh Perspective

Contact Info

Product

Resources

About