Periodontal ligament cells from redundant teeth are supposed to be resources for stem-cell-mediated periodontal regeneration

Han, Qi-Bing; Jia, Jun; Zhao, Yi‐Fang

doi:10.1016/j.mehy.2007.04.021

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…Therefore, to avoid the unexpected nondental characteristics residing in the nondental cells or ethical dilemmas regarding the use of embryonic cells, the promising approach to future tooth reconstruction should be based on postnatal dental stem cells, including epithelial stem cells from rodent apical buds and stem cells from postnatal dental mesenchymal tissues. 5,8,37,38,47,67,68,[70][71][72][73][74][75][76][77][78][79][80][81][82] CONCLUSION Collectively, scientific advances in experimental embryology, developmental and molecular biology, molecular genetics, stem cell biology, bionics, and biotechnology have provided a number of unique opportunities for us to realize the tooth reconstruction. Future strategies will no doubt focus on the in vitro enrichment of dental progenitors, continued optimization of biodegradable scaffolds that can induce odontogenesis, and odontogenic microenvironment necessary for sequential cell differentiation.…”

Section: Candidate Cells In Making a Bio-toothmentioning

confidence: 99%

Current Approaches and Challenges in Making a Bio-Tooth

Shi

Jin

2008

Tissue Engineering Part B: Reviews

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Tooth loss adversely affects not only mouth functions but also the esthetics of one's face. To repair these defects, current treatment methods mainly depend on nonbiological materials or artificial implants that also can, sometimes, reduce the quality of life because of their limited physiological function, or elicit an immunological rejection. Theoretically, a biological tooth (bio-tooth) that is made from the patient's own cells and grows in its intended location should be the best choice for treating tooth loss, although such bioengineered teeth have been nothing more than a dream for many centuries. Recently, significant advances in the fields of tissue engineering, stem cell biology, developmental biology, molecular genetics, and bionics have brought us close to the realization of a bio-tooth. However, issues involving in the reconstruction of a bio-tooth regarding the shape determination, size control, availability of dental epithelium, directional growth and eruption, and graft rejection in the jaws remain to be resolved. Here, this review outlines the current approaches toward the tooth regeneration, and focuses on several key challenges that must be met in the making of a bio-tooth.

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