Periodontal Findings in Patients With Oral Submucous Fibrosis and Comet Assay of Affected Gingival Epithelial Cells

Dodani, Kiran; Naveen, Anumala; Avula, Haritha; Reddy, Krishnajaneya; Varre, Sreedevi; Kalakonda, Butchi Babu; Arora, Nupur; Suri, Charu; Avula, Jaya Kumar

doi:10.1902/jop.2011.110352

Cited by 14 publications

(10 citation statements)

References 34 publications

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“…Studies in the literature have shown the influence of betel nut chewing on the periodontium and it has been proposed that the physical action of the components of the betel nut could be the etiological factor [15]. In the present study, improvement in gingival index and plaque index was observed in group A when compared to group B, but these differences were statistically non significant.…”

Section: Discussioncontrasting

confidence: 65%

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Comparative Study of the Efficacy of Newer Antioxitands Lycopene and Oxitard in the Treatment of Oral Submucous Fibrosis

Patil

Yadav

Al-Zoubi

et al. 2018

Pesqui. bras. odontopediatria clín. integr.

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Objective: To compare the efficacy of oxitard and lycopene in the management of Oral Submucous Fibrosis (OSMF). Material and Methods: 120 subjects with clinicpathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (oxitard) and Group B (lycopene). Group A was administered 2 oxitard capsules twice daily and Group B was given 8 mg lycopene in 2 divided doses of 4 mg for 3 months. Gingival index and plaque index were documented for all patients and compared. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Student's paired t test and Chi-square test. P-value <0.001 was considered to be statistically significant. Results: Clinical improvements in mouth opening and tongue protrusion was significant in Group A (p<0.001). Subjective symptoms of pain associated with the lesion (p=0.0001), difficulty in swallowing (p=0.0004) and speech (p=0.0002) significantly improved in the Group A. However, there was no significant improvement in burning sensation (p>0.001) among the 2 groups. Although the mean gingival index and plaque index in group A was reduced but it was found to be not statistically significant. Conclusion: Oxitard capsules can bring about significant clinical improvements in the symptoms like mouth opening, tongue protrusion, difficulty in swallowing and speech and pain associated with the lesion when compared to lycopene, thereby improving the quality of life of the affected individuals.

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Section: Discussioncontrasting

confidence: 65%

“…Treatment modalities for relieving the symptoms related to oral submucous fibrosis (OSMF) have been advocated, but have not been successful so far [11][12][13][14][15]. The first step of preventive measure should be in advising the patient to discontinue the habit of betel nut chewing, tobacco, spicy foods and chillies.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of the Efficacy of Newer Antioxitands Lycopene and Oxitard in the Treatment of Oral Submucous Fibrosis

Patil

Yadav

Al-Zoubi

et al. 2018

Pesqui. bras. odontopediatria clín. integr.

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“…These histologic features were comparable with those previously described in the oral mucosa from patients with inflammatory pathologies. 27,28 Moreover, the oral mucosa in allergic patients also presented a greater density of collagen fibers, a feature associated with epithelial remodeling. [29][30][31] These patients also had significant structural changes characteristic of a remodeling process, including decreased expression of TJ (claudin-1 and occludin) and AJ (E-cadherin) proteins.…”

Section: Discussionmentioning

confidence: 99%

Profilin-mediated food-induced allergic reactions are associated with oral epithelial remodeling

Rosace

Gómez‐Casado

Fernández

et al. 2019

Journal of Allergy and Clinical Immunology

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“…users do not consume e-liquids) has also been shown to produce harmful effects in periodontal ligament and gingival fibroblasts in culture [17, 18]. While the contribution of smoking tobacco to the progression of periodontal disease and other adverse oral health outcomes is well described [10, 19], no information is available regarding the impact of e-cig aerosols vaping on periodontal/gingival oral health effects, especially in response to e-cig flavoring agents. We determined the effect of flavoring on oxidative and pro-inflammatory responses, and upon exposure of periodontal ligament fibroblasts, Human Gingival Epithelium Progenitors pooled (HGEPp), and epigingival 3D epithelium to menthol flavoring agent resulted in increased oxidative/carbonyl stress, and IL-8 release.…”

Section: Discussionmentioning

confidence: 99%

E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts

et al. 2016

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Electronic-cigarettes (e-cigs) represent a significant and increasing proportion of tobacco product consumption, which may pose an oral health concern. Oxidative/carbonyl stress via protein carbonylation is an important factor in causing inflammation and DNA damage. This results in stress-induced premature senescence (a state of irreversible growth arrest which re-enforces chronic inflammation) in gingival epithelium, which may contribute to the pathogenesis of oral diseases. We show that e-cigs with flavorings cause increased oxidative/carbonyl stress and inflammatory cytokine release in human periodontal ligament fibroblasts, Human Gingival Epithelium Progenitors pooled (HGEPp), and epigingival 3D epithelium. We further show increased levels of prostaglandin-E2 and cycloxygenase-2 are associated with upregulation of the receptor for advanced glycation end products (RAGE) by e-cig exposure-mediated carbonyl stress in gingival epithelium/tissue. Further, e-cigs cause increased oxidative/carbonyl and inflammatory responses, and DNA damage along with histone deacetylase 2 (HDAC2) reduction via RAGE-dependent mechanisms in gingival epithelium. A greater response is elicited by flavored e-cigs. Increased oxidative stress, pro-inflammatory and pro-senescence responses (DNA damage and HDAC2 reduction) can result in dysregulated repair due to proinflammatory and pro-senescence responses in periodontal cells. These data highlight the pathologic role of e-cig aerosol and its flavoring to cells and tissues of the oral cavity in compromised oral health.

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Periodontal Findings in Patients With Oral Submucous Fibrosis and Comet Assay of Affected Gingival Epithelial Cells

Abstract: OSF showed significant changes in affected gingiva, and the presence of comet cells in all the patients with OSF is a significant indicator of possible pathognomonic developments.

Cited by 14 publications

References 34 publications

Comparative Study of the Efficacy of Newer Antioxitands Lycopene and Oxitard in the Treatment of Oral Submucous Fibrosis

Comparative Study of the Efficacy of Newer Antioxitands Lycopene and Oxitard in the Treatment of Oral Submucous Fibrosis

Profilin-mediated food-induced allergic reactions are associated with oral epithelial remodeling

E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts

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