Periodontal effects of two innovative oral rinsing substances in oncologic patients

Abstract

Chemotherapy often presents side effects, including oral adverse effects that may interfere with the completion of the oncology treatment, threatening the outcome of the treatment and significantly affecting the quality of life of the patient. The aim of the present study was to evaluate two antiseptic, antimicrobial and antifungal substances that may be used in order to achieve improved oral hygiene and to lower the prevalence of side effects during chemotherapy. Patients were randomly divided into three groups: Placebo, oral rinse with cetrimide and mouth coating with a pharmacy-made compound (nystatin, neomycin and metronidazole). Their oral hygiene and periodontal parameters were determined at baseline and 14 days of use. It was revealed that the most effective clinical results were achieved in the group that used cetrimide mouth rinse that highlighted the best improvements of parameter values, whereas the control and coating-using group did not obtain statistically significant improvements. Cetrimide oral rinse was demonstrated to be an efficient adjunct method in achieving better oral hygiene and improved periodontal parameters in chemotherapy patients. The present study offers an alternative to the commonly used compounds that may present unwanted side effects in patients during chemotherapy, it promotes the importance of good oral hygiene in the prevention of chemotherapy-induced oral adverse effects and improves the quality of life of the patient.

Prognostic Impact of Dihydropyrimidine Dehydrogenase Germline Variants in Unresectable Non-Small Cell Lung Cancer Patients Treated with Platin-Based Chemotherapy

“…Other associations related to toxicity have been described, such as an increased risk of haematological adverse events in patients with variations determined in UGT1A1 and CYP2C8 [ 22 , 50 ]. Although these findings are not supported by our results, it is necessary to continue research to establish connections between genotype and toxicity to enhance the quality of life and improve treatment adherence in patients experiencing myelosuppression, nephrotoxicity and other limiting side effects such as periodontal disease [ 51 ].…”

The Impact of the COVID-19 Pandemic on Dentistry and Dental Education: A Narrative Review

“…To further increase safety at work, Italian dentists have adopted, as a preventative measure, ventilation of dental treatment rooms after examination of each patient, regardless of the dental treatment performed. In rooms with poor mechanical ventilation, portable air filters with a high-efficiency particulate air filter (HEPA) have effectively reduced aerosol accumulation and accelerated aerosol removal [ 10 ]. Taken together, these studies show that new measures put in place in dental offices significantly mitigate the risks of SARS-CoV-2 contamination, and the risk of contracting COVID-19 in the dental office is relatively low [ 11 ].…”

Title Cross-Sectional Study to Evaluate Knowledge and Attitudes on Oral Hygiene of Romanian Students

“…The Center of Disease Control on Oral Prevention recommendations require a sustained education about food hygiene, oral hygiene as well as the importance of both general and local fluoridation, and sealing [ 1 , 2 , 3 , 4 ]. The long-term implications of oral health will be found in adult oral health, a health issue that affects both carious lesions and periodontal lesions or even cancer [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. The results of specialized studies have highlighted the need to establish educational methods designed to improve the determinants of oral health [ 12 , 13 , 14 , 15 ].…”