Periodontal Disease in the 18-Month-Old Germfree Rat

N, Baer; Rj, Fitzgerald

doi:10.1177/00220345660450023401

Cited by 28 publications

(15 citation statements)

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“…It is beyond argument that, once breached, the periodontal tissues would be vulnerable to superimposed infection, but the fact that periodontal disease can develop in the germ-free state is repeatedly overlooked. This occurrence, first reported by Baer & Newton in 1959 and amply corroborated since (Baer & Newton 1960, Baer & Fitzgerald 1966,can be seen to exhibit the sequential histopathological appearances characteristic of periodontal disease.…”

supporting

confidence: 63%

Scientific Basis for the Prevention of Caries and Periodontal Disease

Cohen

1981

J R Soc Med

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supporting

confidence: 63%

Scientific Basis for the Prevention of Caries and Periodontal Disease

Cohen

1981

J R Soc Med

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“…Diminshed alveolar bone in the oral cavities of germ-free mice and rats was thought to be paradoxical (Baer and Fitzgerald, 1966) given that bone loss was presumed to follow chronic inflammation triggered by an aberrant subgingival community, as in generalized periodontitis. In an effort to address this paradox, other work identified hallmarks of inflammation – mast cells and basophils – in the junctional epithelia of germ-free animals (Wolf et al, 1973).…”

Section: The Immune System As a Source Of Landscape Transformationmentioning

confidence: 99%

The Landscape Ecology and Microbiota of the Human Nose, Mouth, and Throat

Proctor

Relman

2017

Cell Host & Microbe

154

152

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Landscape ecology examines the relationships between the spatial arrangement of different landforms and the processes that give rise to spatial and temporal patterns in local community structure. These relationships that underlie the patterns of the microbial communities that inhabit the human body, and in particular, those of the nose, mouth and throat, deserve greater attention. Important questions include what defines the size of a population (i.e., ‘patch’) in a given body site; what defines the boundaries of distinct patches within a single body site, and where and over what spatial scales within a body site are gradients detected. This review looks at the landscape ecology in the upper respiratory tract and mouth, and seeks greater clarity about the physiological factors, whether immunological, chemical or physical, that govern microbial community composition and function, and the ecological traits that underlie health and disease.

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“…Previous light microscopic studies of spontaneously occurring periodontal disease in rats include those on the rice rat by Mulvihill et al (1967) and those of Baer and Fitzgerald (1966) which demonstrated that slowly developing periodontal disease could develop in germ-free rats.…”

mentioning

confidence: 99%

Histopathogenesis of spontaneous periodontal disease in conventional rats

1979

J of Periodontal Research

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The development of gingivitis and periodontitis lesions in rats fed a normal laboratory chow diet was compared to that which occurred in rats fed a high sucrose diet (Keyes'diet 2000). Histometric analysis of mesio‐distal sections through the 1st maxillary interdetal area revealed that the area of inflamed connectve tissue(ICT) increased more rapidly in the diet 2000 group. A greater incidence of periodontitis lesions with active bone resorption was noted in the diet 2000 group. Analysis of cell types in the ICT revealed no statistically significant differences between the two diet groups. However when the percent age of various cell types present in the periodontitis lesions of both dietary groups were compared to the percentage of the cell typed present in the periodontitis lesions of both dietary groups were compared to the percentage of the cell typed persent in gingivitis lesions a statistically significant increase in both large mononuclear cells was found to exist in the ICT of the Periodontitis lisions. A statistically significant decrease in the number of endothelial cells was also observed in periodontitis lesions. At the ultrastructural level cytopathologic alterations of fibroblasts and decreased collagen fibers were noted beneath the gingival epithelium. Denudation of the cemental surface beneath the epithelial attachment became progressively more severe and preceded the migration of the epithelium along the cemental surface.

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Periodontal Disease in the 18-Month-Old Germfree Rat

Cited by 28 publications

References 0 publications

Scientific Basis for the Prevention of Caries and Periodontal Disease

Scientific Basis for the Prevention of Caries and Periodontal Disease

The Landscape Ecology and Microbiota of the Human Nose, Mouth, and Throat

Histopathogenesis of spontaneous periodontal disease in conventional rats

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